Risedronate tablets and delayed-release (long-acting tablets) are used to prevent and treat osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause (''change of life,'' end of menstrual periods). Risedronate tablets are also used to treat osteoporosis in men, and in men and women who are taking glucocorticoids (a type of corticosteroid medication that may cause osteoporosis). Risedronate tablets are also used to treat Paget's disease of bone (a condition in which the bones are soft and weak and may be deformed, painful, or easily broken). Risedronate is in a class of medications called bisphosphonates. It works by preventing bone breakdown and increasing bone density (thickness).
Risedronate comes as a tablet and a delayed-release tablet to take by mouth. The delayed-release tablets are usually taken once a week in the morning, immediately after breakfast. The tablets are usually taken on an empty stomach once a day in the morning, once a week in the morning, once monthly in the morning, or once monthly for two mornings in a row depending on your condition and the dosage prescribed by your doctor. If you are taking risedronate once a week, once monthly, or once monthly for 2 days in a row, take it on the same day every week or month or the same 2 days in a row every month. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take risedronate exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor.
Risedronate may not work properly and may damage the esophagus (tube that connects the mouth and stomach) or cause sores in the mouth if it is not taken according to the following instructions. Tell your doctor if you do not understand, you do not think you will remember, or you are unable to follow these instructions:
Risedronate controls osteoporosis and Paget's disease of bone but does not cure these conditions. Risedronate helps to treat and prevent osteoporosis only as long as it is taken regularly. Continue to take risedronate even if you feel well. Do not stop taking risedronate without talking to your doctor, but talk to your doctor from time to time about whether you still need to take risedronate.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with risedronate and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website ( Web Site) or the manufacturer's website to obtain the Medication Guide.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before taking risedronate,
You should eat plenty of foods that are rich in calcium and vitamin D while you are taking risedronate. Your doctor will tell you which foods are good sources of these nutrients and how many servings you need each day. If you find it difficult to eat enough of these foods, tell your doctor. In that case, your doctor can prescribe or recommend a supplement.
If you miss a dose of once-daily risedronate, do not take it later in the day. Skip the missed dose and take one dose the next morning as usual.
If you miss a dose of once-weekly risedronate, do not take it later in the day. Take one dose the morning after you remember. Then return to taking one dose once each week on your regularly scheduled day.
If you miss a dose of once-monthly risedronate but remember more than 7 days before your next scheduled dose, take the missed dose the morning after you remember. If you remember less than 7 days before your next scheduled dose, do not take the missed dose. Instead, wait until the morning of your next scheduled dose and then take risedronate as usual.
If you miss one or both doses of the two days in a row, once-monthly risedronate but remember more than 7 days before your next scheduled dose, you can take the missed doses. Take the first missed dose the morning after you remember and if you missed both doses, take the second missed dose the morning after you take the first one. If you remember less than 7 days before your next scheduled dose, do not take the missed dose(s). Instead, wait until the morning of your next scheduled dose and then take risedronate as usual.
If you miss doses of risedronate and do not know what to do, call your doctor. Always take risedronate first thing in the morning. Never take a double dose to make up for a missed one, and never take more than one dose in one day.
Risedronate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of the following side effects, call your doctor immediately before you take any more risedronate:
Risedronate may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Taking a bisphosphonate medication such as risedronate for osteoporosis may increase the risk that you will break your thigh bone(s). You may feel pain in your hips, groin, or thighs for several weeks or months before the bone(s) break, and you may find that one or both of your thigh bones have broken even though you have not fallen or experienced other trauma. It is unusual for the thigh bone to break in healthy people, but people who have osteoporosis may break this bone even if they do not take risedronate. Talk to your doctor about the risks of taking risedronate.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( Web Site) or by phone (1-800-332-1088).
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( Web Site) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. Web Site
In case of overdose, give the victim a full glass of milk and call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include the following:
Keep all appointments with your doctor and the laboratory.
Before having any laboratory test or bone imaging study, tell your doctor and the laboratory personnel that you are taking risedronate.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.