Throughout life, bones are constantly being broken down and rebuilt. In the cases of osteoporosis and Paget disease, this natural cycle is altered. This change, along with other factors, leads to a loss of bone (osteoporosis), or loss of bone at some places in the body and thickening of bone in other places (Paget disease). Alendronate helps to improve overall bone mass by inhibiting its breakdown.
It is important that your doctor check your progress at regular visits, to allow for dosage adjustments and to help reduce side effects. The following information may affect your usage of alendronate, so be sure to tell your doctor if you are:
Alendronate may make some medical conditions worse. Tell your doctor if you have any medical problems, especially:
Take alendronate in the morning on an empty stomach. Take with a full glass of plain water and wait at least 30 minutes before consuming any food, beverage, or other medicines. Food and beverages other than plain water will decrease the amount of alendronate absorbed by the body. Medications, such as antacids, or calcium or vitamin supplements, will also decrease absorption. Waiting at least 30 minutes allows for more of the drug to be absorbed.
Do not lie down for 30 minutes after taking this drug. Staying upright will help the alendronate reach your stomach faster, and will help prevent irritation in your throat.
You may be advised to increase the amount of calcium and vitamin D in your diet. Both of these nutrients are important for bone health. You can get these nutrients through foods, but your doctor may also recommend a supplement.
Sources of calcium include:
Sources of vitamin D include:
Take a missed dose as soon as possible. If you miss a daily dose, resume the next day. If you miss a weekly dose, resume the next day and again the following week on the scheduled day. Do not double up on doses.
Check with your doctor as soon as possible if any of the following side effects occur:
Check with your doctor if any of the following side effects occur frequently and/or become bothersome:
The National Institutes of Health Osteoporosis and Related Bone Diseases
US Food and Drug Administration
The College of Family Physicians of Canada
College of Pharmacists of British Columbia
Alendronate. EBSCO DynaMed Plus website. Available at:https://www.dynamed.com/topics/dmp~AN~T233482/Alendronate. Updated July 7, 2017. Accessed July 31, 2017.
Fosamax (alendronate sodium tablet). US National Library of Medicine Daily Med website. Available at: http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f2dcfb39-a7c2-4e39-9e35-852a3a74f947#section-8.1. Updated March 21, 2016. Accessed July 31, 2017.
Osteoporosis. EBSCO DynaMed Plus website. Available at:https://www.dynamed.com/topics/dmp~AN~T113815/Osteoporosis. Updated July 26, 2017. Accessed July 31, 2017.
Last reviewed July 2017 by Michael Woods, MD, FAAP Last Updated: 8/12/2015