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Lobular Carcinoma in Situ

(LCIS)

Definition

Lobular carcinoma in situ (LCIS) is when there are abnormal cells in the lobules of the breast. The lobules are the part of the breast that produces milk. LCIS is not cancer. However, it can raise the risk of future breast cancer.

Causes

It is not clear what causes LCIS. It is likely due to a change in a gene.

Risk Factors

LCIS is more common in premenopausal women between 40 to 50 years old.

Symptoms

LCIS does not have symptoms.

Diagnosis

LCIS does not appear on imaging tests. It cannot be felt during a breast exam. It is usually found during a biopsy of other nearby breast tissue.

Treatment

LCIS does not require treatment.

The doctor will monitor the breast for changes with:

  • A physical and breast exam every 6 to 12 months
  • A yearly mammogram

Prevention

The risk of breast cancer may be reduced by:

  • Reaching and keeping a healthy weight
  • Regular physical activity
  • Eating a healthful diet
  • Avoiding alcohol or—or limiting it to 1 drink or less per day
RESOURCES:

American Cancer Society
https://www.cancer.org

National Cancer Institute
https://www.cancer.gov

CANADIAN RESOURCES:

Canadian Cancer Society
http://www.cancer.ca

Health Canada
https://www.canada.ca

REFERENCES:

LCIS—lobular carcinoma in situ. Breast Cancer website. Available at: http://www.breastcancer.org/symptoms/types/lcis. Accessed March 19, 2021.

Lobular carcinoma in situ. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/lobular-carcinoma-in-situ. Accessed March 19, 2021.

Lobular carcinoma in situ (LCIS). American Cancer Society website. Available at: https://www.cancer.org/cancer/breast-cancer/non-cancerous-breast-conditions/lobular-carcinoma-in-situ.html. Accessed March 19, 2021.

Wen HY, Brogi E. Lobular carcinoma in situ. Surg Pathol Clin. 2018;11(1):123-145.

Last reviewed January 2021 by EBSCO Medical Review Board Mohei Abouzied, MD, FACP  Last Updated: 3/19/2021