A risk factor is something that increases your likelihood of getting a disease or condition.
It is possible to develop stomach cancer with or without the risk factors listed below. However, the more risk factors you have, the greater your chance of developing stomach cancer. If you have a number of risk factors, ask your doctor what you can do to reduce your risk.
In general, risk increases in people over 50 years old, but most stomach cancers are found in people aged 60-85 years old. Stomach cancer is twice as likely to affect men than women. Stomach cancer risk is also higher in people of eastern Asia, eastern Europe, and South American descent.
Stomach cancer has been strongly associated with lifestyle factors. The following factors may increase the risk:
Smoking— Tobacco contains cancer-causing agents (carcinogens) that can cause irritation and cellular changes in the stomach lining. The top part of the stomach closest to the esophagus is most the vulnerable. The risk of cancer increases with the amount of tobacco used and the number of years as a tobacco user. All forms of tobacco are strongly associated with stomach cancer, nearly doubling the risk of the disease. The risk drops once tobacco use is stopped.
Diet—Diets high in red meat, excess salt, or lack of fruits and vegetables increase the risk. Risk is higher in those who eat salted, preserved, pickled, smoked, or cured meats. Foods with nitrates such as deli or processed meats also increase cancer risk.
Excessive alcohol use—Alcohol itself is not considered a carcinogen, but three or more drinks a day may cause irritation to the stomach lining, especially in the area closest to the esophagus. The risk is compounded in those who smoke.
Occupational exposures—Coal, metal, and rubber industry employees face the highest risk of stomach cancer in the workplace.
Several medical conditions may increase the risk of stomach cancer. These include:
Helicobacter pylori infection (H. pylori)—
A type of bacteria known to cause gastric ulcers and chronic inflammation of the stomach lining. The longer that the infection is present, the more risk increases. H. pylori is easily treated with antibiotics.
Gastric cancer. National Cancer Institute website. Available at: https://www.cancer.gov/types/stomach/patient/stomach-treatment-pdq. Updated April 27, 2017. Accessed September 1, 2017.
Smoking and the digestive system. National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: https://www.niddk.nih.gov/health-information/digestive-diseases/smoking-digestive-system. Updated September 2013. Accessed September 1, 2017.
Stomach cancer. Merck Manual Professional Version website. Available at: http://www.merckmanuals.com/professional/gastrointestinal-disorders/tumors-of-the-gi-tract/stomach-cancer. Updated January 2017. Accessed September 1, 2017.
What are the risk factors for stomach cancer? American Cancer Society website. Available at: https://www.cancer.org/cancer/stomach-cancer/causes-risks-prevention/risk-factors.html. Updated February 10, 2016. Accessed September 1, 2017.
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