Carl R. Darnall Army Medical Center - Health Library

Clonidine

Clonidine is often used to reduce blood pressure as well as to counter symptoms that occur during withdrawal from alcohol and other addictive substances.

 

Interaction

Substance: Coenzyme Q10 (CoQ10)

Effect: Supplementation Possibly Helpful

There is some evidence that clonidine might impair the body's ability to manufacture the substance coenzyme Q 10 (CoQ 10).1 However, it has not yet been shown that CoQ 10 supplements offer any particular benefit to those taking this medication.

Interaction

Substance: Yohimbe

Effect: Probable Dangerous Interaction

If you are taking clonidine, it is not safe to take yohimbe.2

Interaction

Substance: Coleus forskohlii

Effect: Theoretical Interaction

The herb Coleus forskohlii relaxes blood vessels and might have unpredictable effects if combined with clonidine.

 

References

1. Kishi H, et al. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q 10 -enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 12(3): 533–540, 1975.

2. Brinker F. Herb contraindications and drug interactions, 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998: 140–141.

Last reviewed December 2015 by EBSCO CAM Review Board  Last Updated: 12/15/2015