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Henoch-Schonlein Purpura

(Anaphylactoid Purpura; HSP; Vascular Purpura)

Pronounced: Hen-awk-shern-line purr-purr-ah

Definition

Henoch-Schonlein purpura (HSP) is inflammation of the blood vessels in the skin and other body organs. When it involves the skin, it causes a specific rash. The rash looks like bruising or small dots in the skin, referred to as purpura.

Causes    TOP

HSP is caused by an abnormal reaction of the immune system. Normally, the immune system marks and attacks foreign items like viruses and bacteria. However, with HSP, the immune system attacks the blood vessels. It is not clear why the immune system attacks the body.

The change in the immune system may be triggered by:

  • Bacterial or viral infections
  • Certain medications
  • Recent exposure to certain vaccines
  • Infection by insect bites

HSP occurs most often after a respiratory infection. HSP is not contagious.

Risk Factors    TOP

HSP is most common in children aged 2 to 11 years old, but it can occur at any age. Factors that increase your risk of HSP include:

  • Recent upper respiratory illness, such as a cold
  • Recent exposure to vaccines, chemicals, cold weather, or insect bites

Symptoms    TOP

Symptoms may last for 4 to 6 weeks and may include:

  • Skin rash:
    • Reddish-purple spots that can be felt and are not itchy
    • Often appears on the buttocks or legs, may appear on the elbows
    • Red spots of various sizes
    • Bruising, usually below the waist
  • Pain in the joints, especially knees and ankles
  • Abdominal pain
  • Blood in the urine
  • Swelling of the ankles
  • Swelling of the scrotum in males
  • Fever
  • Blood in the stool
  • Vomiting

Diagnosis    TOP

You will be asked your symptoms and medical history. A physical exam will be done.

Your bodily fluids, tissues, and waste may be tested. This can be done with:

  • Blood tests
  • Urinalysis
  • Stool sample
  • Skin biopsy from an area of the rash

Skin Biopsy

Skin proceedure
Copyright © Nucleus Medical Media, Inc.

Treatment    TOP

HSP usually gets better on its own. Your doctor may prescribe medications if symptoms or complications are causing problems. Medications may include:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs)—to lessen joint pain and arthritis
  • Steroid medication—for significant abdominal pain, joint pain, or kidney disease
  • Antibiotics—to treat bacterial infection
  • Immune system suppressants when you have symptoms of severe kidney disease

Prevention    TOP

There are no guidelines to prevent HSP. Relapse occurs in about half of all cases.

It is important to make sure that you have long-term, follow-up visits with your doctor to be sure that kidney disease doesn't develop.

RESOURCES:

American Autoimmune Related Diseases Association
http://www.aarda.org
Family Doctor—American Academy of Family Physicians
http://www.familydoctor.org

CANADIAN RESOURCES

Caring for Kids—Canadian Paediatric Society
http://www.caringforkids.cps.ca
College of Family Physicians of Canada
http://www.cfpc.ca

References:

Dillon MJ. Henoch-Schonlein purpura (treatment and outcome). Cleve Clin J Med. 2002;69(Suppl 2):SII121-SII123.
Henoch-Schonlein purpura. EBSCO DynaMed Plus website. Available at: http://www.dynamed.... Updated November 5, 2015. Accessed June 13, 2016.
Henoch-Schonlein purpura. National Institute of Diabetes and Digestive and Kidney Disease website. Updated September 7, 2012. Available at:
...(Click grey area to select URL)
Updated March 2014. Accessed June 13, 2016.
Henoch-Schonlein purpura. National Institute of Health Office of Rare Disease Research website. Available at:
...(Click grey area to select URL)
Accessed June 13, 2016.
Kraft D, McKee D, et al. Henoch-Schonlein purpura: a review. Am Fam Physician. 1998 Aug 1;58(2):405-408. Available at:
...(Click grey area to select URL)
Accessed June 13, 2016.
Ronkainen J, Koskimies O, et al. Early prednisone therapy in Henoch-Schonlein purpura: a randomized, double-blind, placebo-controlled trial. J Pediatr. 2006;149:241-247.
Saulsbury FT. Epidemiology of Henoch-Schonlein purpura. Cleve Clin J Med. 2002;69(Suppl 2):SII87-SII89.
Last reviewed June 2016 by Michael J. Fucci, DO
Last Updated: 5/11/2013

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