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Supplement Forms/Alternate Names

Elemental Iodine; Iodide

Principal Proposed Uses

Correcting Nutritional Deficiency

Other Proposed Uses

Cyclic Mastalgia

Your thyroid gland, located just above the middle of your collarbone, needs iodine to make thyroid hormone, which maintains normal metabolism in all cells of the body. Principally found in sea water, dietary iodine can be scarce in many inland areas, and deficiencies were common before iodine was added to table salt. Iodine deficiency causes enlargement of the thyroid, a condition known as goiter. However, if you are not deficient in iodine, taking extra iodine will not help your thyroid work better, and it might even cause problems.

For reasons that are not clear, supplementary iodine might also be helpful for cyclic mastalgia.


The official US recommendations for daily intake of iodine are as follows:

  • Infants
    • 0-6 months: 110 mcg
    • 7-12 months: 130 mcg
  • Children
    • 1-8 years: 90 mcg
  • Males and females
    • 9-13 years: 120 mcg
    • 14 years and older: 150 mcg
  • Pregnant women: 220 mcg
  • Nursing women: 290 mcg

Iodine deficiency is rare in developed countries today because of the use of iodized salt.

Seafood and kelp contain very high levels of iodine, as do salty processed foods that use iodized salt.

Most iodine is in the form of iodide, but a few studies suggest that a special form of iodine called molecular iodine may be better than iodide.

Therapeutic Dosages    TOP

A typical therapeutic dosage of iodide or iodine is 200 mcg daily.

Therapeutic Uses    TOP

Iodine supplements have been proposed as a treatment for cyclic mastalgia. Cyclic mastalgia is characterized by breast pain and lumpiness that usually cycles in relation to the menstrual period.1

What Is the Scientific Evidence for Iodine?    TOP

Three clinical studies provide weak evidence that supplements providing iodine may be helpful in treating cyclic mastalgia.1 These studies suggest that either iodide or iodine (the pure molecular form) might be useful. In the one double-blind, placebo-controlled trial among this group, a study that enrolled 56 individuals, molecular iodine was found superior to placebo in relieving pain and reducing the number of cysts.

Another of these studies compared molecular iodine to iodide. Molecular iodine was no more effective than iodide, but was deemed superior because it induced fewer side effects and did not affect the thyroid.

Safety Issues    TOP

When taken at the recommended dosage, iodine and iodide are safe nutritional supplements. However, excessive doses of iodide can actually cause thyroid problems, including both hypothyroidism and hyperthyroidism. There is also a speculative link between excessive iodide intake and thyroid cancer. For these reasons, iodide intake above nutritional recommendations is not advised except under physician supervision.

References[ + ]

1. Ghent WR, Eskin BA, Low DA, et al. Iodine replacement in fibrocystic disease of the breast. Can J Surg. 1993;36:453-460.

Last reviewed December 2015 by EBSCO CAM Review Board
Last Updated: 12/15/2015

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