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Surgical Procedures for Epilepsy
by Rick Alan
Surgery to treat epilepsy is most likely to be successful when:
Before the decision to have surgery is made, you and your doctor must consider the following factors:
The main types of surgery used to treat epilepsy are:
Lobectomy or Lesionectomy
This procedure involves removal of the area of the brain that is producing the seizures, called the seizure focus. This procedure is only appropriate in patients who have partial seizures that occur in just one part of the brain. The surgery is often successful in reducing seizure frequency. It is especially useful in patients with certain kinds of temporal lobe epilepsy.
Multiple Subpial Transection
This involves a series of cuts along the nerve path by which seizure impulses spread. The surgery is designed to prevent seizures from spreading into other parts of the brain, while leaving the patient’s normal abilities in place. This is sometimes done alone and sometimes done in addition to a lobectomy. Alone, it is done in patients whose epileptic seizures occur in a part of the brain that cannot be removed. This surgery improves seizure control about 70% of the time. Multiple subpial transection is done less often than a lobectomy.
Corpus Callosotomy TOP
This surgery involves cutting the nerve connections between the right and left hemispheres of the brain to prevent seizures from spreading from one side to the other. It is often done in 2 steps. The first operation partially separates the 2 halves of the brain, but it leaves some connections in place. If the generalized seizures stop, no additional surgery is done. If seizures continue, a second operation that completes the separation may be done.
Corpus callosotomy is done primarily in children with severe seizures that start in one hemisphere of the brain and spread to the other. The surgery can help prevent generalized seizures. However, the surgery does not prevent seizures in the side of the brain where the seizure originates.
This surgery involves the removal of half of the brain's outer layer, called the cortex. It is usually done only in children whose epilepsy is not responding well to medication and who have one of these conditions:
Recovery requires intense rehabilitation in order to regain normal functions. However, after this surgery, children usually:
About half of patients need to remain on their medications after this surgery. And, about half can slowly be tapered off medications if they are seizure-free for 12 months.
The chance of recovery from this surgery is best in young children. Therefore, a hemispherectomy is done as early as possible in a child’s life and almost never done in children over age 13.
Surgical Implants TOP
There are two Food and Drug Administration (FDA)-approved devices that are surgically implanted under the skin. The devices help manage seizures in people whose symptoms are not well-controlled with medication.
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Epilepsy in children. EBSCO DynaMed Plus website. Available at: http://www.dynamed.... Updated December 8, 2016. Accessed February 6, 2017.
Epilepsy information page. National Institute of Neurological Disorders and Stroke website. Available at: https://www.ninds.nih.gov/Disorders/All-Disorders/Epilepsy-Information-Page. Accessed February 6, 2017.
FDA approves medical device to treat epilepsy. Food and Drug Administration website. Available at:
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Updated November 14, 2013. Accessed February 6, 2017.
US approves antiepileptic brain implant. Epilepsy Research UK website. Available at:https://www.epilepsyresearch.org.uk/us-approves-antiepileptic-brain-implant. Accessed February 6, 2017.
Treating seizures and epilepsy. Epilepsy Foundation website. Available at:
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Accessed February 6, 2017.
Wiebe S, Blume WT, Girvin JP, Eliasziw M, Effectiveness and Efficiency of Surgery for Temporal Lobe Epilepsy Study Group. A randomized, controlled trial of surgery for temporal-lobe epilepsy. N Engl J Med. 2001;345(5):311-318.
Last reviewed February 2017 by Rimas Lukas, MD
Last Updated: 3/15/2015
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