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Conditions InDepth: Chronic Fatigue Syndrome (CFS)
by Amy Scholten, MPH
Chronic fatigue syndrome (CFS) is a chronic, debilitating disorder. It affects the brain and multiple parts of the body. It causes extreme fatigue and is not relieved by bed rest. Physical or mental fatigue often makes the condition worse. Symptoms last at least 6 months and are severe enough to interfere with daily activities.
There is no specific lab test or clinical sign for CFS. No one knows exactly how many people are affected by this illness. The Centers for Disease Control and Prevention estimates that as many as 500,000 people in the United States have a CFS-like condition.
No one knows what causes CFS. For more than a century, doctors have reported seeing illnesses similar to it. In the 1860s, Dr. George Beard named the syndrome "neurasthenia." He thought it was a nervous disorder with weakness and fatigue. More recent experiments have supported his idea that the brain is somehow involved in CFS.
Health experts have suggested some explanations for this baffling illness, including:
Recovery time varies among individuals with CFS. You may recover to the point where you can resume work and other activities. You may continue to experience various or periodic CFS symptoms. CFS typically follows a cyclical course. It alternates between periods of illness and relative well-being. You may also recover completely with time.
What are the risk factors for chronic fatigue syndrome?
What are the symptoms of chronic fatigue syndrome?
How is chronic fatigue syndrome diagnosed?
What are the treatments for chronic fatigue syndrome?
Are there screening tests for chronic fatigue syndrome?
How can I reduce my risk of chronic fatigue syndrome?
What questions should I ask my doctor?
What is it like to live with chronic fatigue syndrome?
Where can I get more information about chronic fatigue syndrome?
Chronic fatigue syndrome. Family Doctor—American Academy of Family Physicians website. Available at:
...(Click grey area to select URL)
Accessed May 31, 2017.
Chronic fatigue syndrome. EBSCO DynaMed Plus website. Available at: http://www.dynamed.... Updated February 10, 2017. Accessed May 31, 2017.
Chronic fatigue syndrome (CFS). Centers for Disease Control and Prevention website. Available at:
...(Click grey area to select URL)
Updated April 7, 2015. Accessed May 31, 2017.
Devanur LD, Kerr JR. Chronic fatigue syndrome. J Clin Virol. 2006;37(3):139-150.
Prins JB, van der Meer JW, Bleijenberg G. Chronic fatigue syndrome. Lancet. 2006;367(9507):346-355.
Last reviewed May 2017 by James P. Cornell, MD
Last Updated: 12/20/2014
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