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Medications for Metabolic Syndrome

Since metabolic syndrome is a group of risk factors, your doctor may prescribe medications to manage these specific risk factors. For example, if you have diabetes or high blood pressure, your doctor may give you specific medications to help control those levels.

Examples of types of medications to help control blood pressure include:

  • Diuretics
  • Angiotensin converting enzyme inhibitors
  • Beta blockers
  • Calcium channel blockers

Examples of medications to control blood sugar levels if you have type 2 diabetes include:

  • Metformin
  • Glitazones
  • Sulfonylureas
  • Insulin

Examples of medications used to manage high triglyceride levels include:

  • Statins
  • Fibrates
  • Niacin
  • Omega-3 fatty acids

References:

Brazg R, Xu L, Dalla Man C, Cobelli C, Thomas K, Stein PP. Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes. Diabetes Obes Metab. 2007;9(2):186-193.
Cornier MA, Dabelea D, Hernandez TL, et al. The metabolic syndrome. Endocr Rev. 2008;29(7):777-822.
Despres JP, Golay A, Sjöström L, Rimonabant in Obesity-Lipids Study Group. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med. 2005;353(20):2121-2134.
Diabetes mellitus type 2 in adults. EBSCO DynaMed Plus website. Available at: http://www.dynamed.... Updated August 29, 2016. Accessed September 23, 2016.
Freemark M. Pharmacotherapy of childhood obesity. Diabetes Care. 2007;30(2):395-402.
How is metabolic syndrome treated? National Heart, Lung, and Blood Institute website. Available at:
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Updated November 3, 2011. Accessed May 10, 2013.
Hypertension. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T115345/Hypertension. Updated June 26, 2014. Accessed September 30, 2014.
Hypertriglyceridemia. EBSCO DynaMed Plus website. Available at: http://www.dynamed.... Updated July 6, 2016. Accessed September 23, 2016.
Li Z, Maglione M, Tu W, et al. Meta-analysis: pharmacologic treatment of obesity. Ann Intern Med. 2005;142(7):532-546.
Medication. American Diabetes Association website. Available at:
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Accessed May 10, 2013.
Metabolic syndrome in adults. EBSCO DynaMed Plus website. Available at: http://www.dynamed.... Updated March 11, 2016. Accessed September 23, 2016.
Orchar TJ, Temprosa M, Goldberg R, et al. The effect of diet and exercise or metformin on the metabolic syndrome: The diabetes prevention program randomized trial. Ann Intern Med. 2005;142(8):611-619.
Rosenstock J, Fitchet M. Vildagliptin: clinical trials programme in monotherapy and combination therapy for type 2 diabetes. Int J Clin Pract Suppl. 2008;(159):15-23.
Skulas-Ray AC, West SG, Davidson MH, Kris-Etherton PM. Omega-3 fatty acid concentrates in the treatment of moderate hypertriglyceridemia. Expert Opin Pharmacother. 2008;9(7):1237-1248.
Steinberger J, Daniels SR, Eckel RH, et al. AHA scientific statement: progress and challenges in metabolic syndrome in children and adolescents. Circulation. 2009;119(4):628-647.
Types of blood pressure medications. American Heart Association website. Available at:
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Updated August 14, 2012. Accessed May 10, 2013.
Last reviewed June 2016 by James Cornell, MD
Last Updated: 5/20/2015

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