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Hydralazine causes dilation of the walls of blood vessels and is sometimes used to treat hypertension.
Supplementation Likely Helpful
Hydralazine is known to deplete the blood of vitamin B 6. Taking B 6 supplements may prevent or reverse side effects of the medication.1,2
Supplementation Possibly Helpful
There is some evidence that hydralazine might impair the body's ability to manufacture the substance coenzyme Q 10 (CoQ 10).3 This suggests (but definitely does not prove) that taking CoQ 10 supplements may produce a beneficial effect.
The herb Coleus forskohlii relaxes blood vessels and might have unpredictable effects if combined with hydralazine.
References [ + ]
1. Shils M, et al. (eds.). Modern nutrition in health and disease, 9th ed. Baltimore: Williams and Wilkins, 1999: 1634.
2. Goodman L and Gilman A. The pharmacological basis of therapeutics, 9th ed. Hardman J, et al (eds.). New York: McGraw-Hill, 1996: 1562.
3. Kishi H, et al. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q 10 -enzymes by clinically used anti-hypertensive drugs. Res Commun ChemPathol Pharmacol 12(3): 533–40, 1975.
Last reviewed December 2015 by EBSCO CAM Review Board
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