Help certain people decrease their risk of cardiovascular disease (CVD),
stroke, and death if used along with diet and exercise
Lower total cholesterol and triglycerides
Lower LDL-cholesterol (bad cholesterol)
Raise HDL-cholesterol (good cholesterol)
Lower C-reactive protein levels—a marker of inflammation, which is thought to increase risk of CVD
Although some people can attain their goals with diet and exercise alone, statins may be prescribed based on your overall risk of having a
or stroke in the next 10 years. Communication is an important aspect of your care. If you have questions or concerns about taking medications when your cholesterol numbers are on target, talk to your doctor about them.
It is important that your doctor check your progress. Regular visits will allow for dosage adjustments and to help monitor for any side effects.
Statins should not be taken during pregnancy. Cholesterol production is essential for normal fetal development. Statins decrease cholesterol production and therefore, may cause birth defects. Women who are able to become pregnant should use birth control while taking a statin drug. Tell your doctor if you think you might be pregnant or you are considering becoming pregnant. Also tell your doctor if you are breastfeeding, as statins may cause problems for a nursing baby.
Excessive amounts of alcohol combined with statin drugs can have bad affects on the liver. Moderation in alcohol consumption is generally defined as one drink per day for women and two drinks per day for men.
Do not stop taking your statin medication without first checking with your doctor. When you stop, your cholesterol levels may increase, and your doctor may want to use other ways to keep cholesterol levels within a more desirable range.
Lovastatin works better when it is taken with food. If you are taking lovastatin once a day, take it with the evening meal. If you are taking more than one dose a day, take each dose with a meal or snack.
If you are taking another kind of statin, ask the pharmacist if you need to take it with food.
If you miss a dose of your statin drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Avoid double doses.
Statin drugs are generally considered safe and few people need to discontinue them due to adverse effects. The side effects listed here have been reported for at least one of the statins, not necessarily all of them. However, since many of the effects of statins are similar, it is possible that these side affects may occur with any one of these medications, although they may be more common with some than with others.
The most significant adverse effects, though rare, involve the liver (elevated liver enzymes) and the muscles (different conditions called myopathy and
Other potential adverse effects include changes in mental status, such as memory loss and confusion, and increased blood glucose levels.
Go to any follow-up appointments recommended by your doctor. Statins and their side effects can be monitored. If needed, your dosage or medication may be changed.
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Controlling cholesterol with statins. Food and Drug Administration website. Available at: ...(Click grey area to select URL) Updated August 31, 2015. Accessed February 16, 2016.
New statin guidelines: Do they apply to you? Harv Health Lett. 2014;39(4):8.
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1/30/2009 DynaMed's Systematic Literature Surveillance ...(Click grey area to select URL) Mills EJ, Rachlis B, Wu P, Devereaux PJ, Arora P, Perri D. Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients. J Am Coll Cardiol. 2008;52(22):1769-1781.
3/6/2012 DynaMed's Systematic Literature Surveillance ...(Click grey area to select URL) FDA announces safety changes in labeling for some cholesterol-lowering drugs. US Food and Drug Administration website. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm293623.htm. Updated March 2, 2012. Accessed February 16, 2016.