Help certain people decrease their risk of cardiovascular disease (CVD),
stroke, and death if used along with diet and exercise
Lower total cholesterol
Lower LDL-cholesterol (bad cholesterol)
Lower C-reactive protein levels—a marker of inflammation
Although some people can attain their goals with diet and exercise alone, statins may be prescribed based on your overall risk of having a
heart attack
or stroke in the next 10 years. Communication is an important aspect of your care. If you have questions or concerns about taking medications when your cholesterol numbers are on target, talk to your doctor about them.
It is important that your doctor check your progress. Regular visits will allow for dosage adjustments and to help monitor for any side effects.
Avoid Pregnancy
Statins should not be taken during pregnancy. Cholesterol production is essential for normal fetal development. Statins decrease cholesterol production and therefore, may cause birth defects. Women who are able to become pregnant should use birth control while taking a statin drug. Tell your doctor if you think you might be pregnant or you are considering becoming pregnant. Also tell your doctor if you are breastfeeding, as statins may cause problems for a nursing baby.
Tell your doctor about all the medications you take. Some medications should not be taken with statins, while others may require a different dosage level. Examples of these include:
Antifungals, such as fluconazole,
itraconazole,
or ketoconazole
Immunosuppresants, such as cyclosporine
Digoxin—some statins may increase blood levels of digoxin, increasing the risk of side effects
Macrolide antibiotics, such as erythromycin or clarithromycin
Fibric acid derivatives, such as gemfibrozil
Niacin
or nicotinic acid—use of this type of medication with a statin may increase the risk of developing muscle problems
Oral contraceptives/birth control pills—some statin drugs may increase the blood levels of the hormones in birth control pills, increasing the risk of side effects
Antidepressants, such as nefazodone
Talk to your doctor about the medications that you take and whether there could be an interaction with the statin.
Recent major surgery or
trauma, which may increase the risk of problems that may lead to kidney failure
Impending surgery, including dental surgery or emergency treatment—be sure to tell the doctor or dentist treating you that you are taking a statin drug
Excessive amounts of alcohol combined with statin drugs can have bad affects on the liver. Moderation in alcohol consumption is generally defined as one drink per day for women and two drinks per day for men.
Do not stop taking your statin medication without first checking with your doctor. When you stop, your cholesterol levels may increase, and your doctor may want to use other ways to keep cholesterol levels within a more desirable range.
Lovastatin works better when it is taken with food. If you are taking lovastatin once a day, take it with the evening meal. If you are taking more than one dose a day, take each dose with a meal or snack.
If you are taking another kind of statin, ask the pharmacist if you need to take it with food.
If you miss a dose of your statin drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Avoid double doses.
Statin drugs are generally considered safe and few people need to discontinue them due to adverse effects. The side effects listed here have been reported for at least one of the statins, not necessarily all of them. However, since many of the effects of statins are similar, it is possible that these side affects may occur with any one of these medications, although they may be more common with some than with others.
Adverse Effects
The most significant adverse effects, though rare, involve the liver (elevated liver enzymes) and the muscles (different conditions called myopathy and
rhabdomyolysis).
Other potential adverse effects include changes in mental status, such as memory loss and confusion, and increased blood glucose levels.
Go to any follow-up appointments recommended by your doctor. Statins and their side effects can be monitored. If needed, your dosage or medication may be changed.
Atorvastatin. EBSCO DynaMed website. Available at: https://www.dynamed.com/drug-monograph/atorvastatin. Updated November 30, 2018. Accessed September 10, 2019.
New statin guidelines: Do they apply to you? Harv Health Lett. 2014;39(4):8.
Statins. EBSCO DynaMed website. Available at: ...(Click grey area to select URL) Updated August 29, 2019. Accessed September 10, 2019.
Statins for primary and secondary prevention of cardiovascular disease. EBSCO DynaMed website. Available at: ...(Click grey area to select URL) Updated April 1, 2019. Accessed February 16, 2016.
3/6/2012 DynaMed's Systematic Literature Surveillance ...(Click grey area to select URL) FDA announces safety changes in labeling for some cholesterol-lowering drugs. US Food and Drug Administration website. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm293623.htm. Updated March 2, 2012. Accessed February 16, 2016.
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