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Smoking Cessation Drugs: Bupropion

Type of Medication

Bupropion is an antidepressant.

What Bupropion Is Prescribed For    TOP

Bupropion is an antidepressant, but it is also prescribed to help people quit smoking. It can be used alone or in combination with a nicotine replacement product.

How Bupropion Works

Bupropion appears to affect 2 brain chemicals that may be related to nicotine addiction: dopamine and norepinephrine. Bupropion reduces the cravings that smokers get when they try to quit. It also seems to reduce many of the nicotine withdrawal symptoms, such as irritability, frustration, and anger.

Considerations While Taking This Medication    TOP

See Your Doctor

Your doctor will determine the appropriate level of bupropion for you and will adjust the dosage as you progress.

Manage Your Medications

Tell your doctor about all the medications you take. Some should not be taken with bupropion. For example, you should not take bupropion for smoking cessation if you:

  • Are already taking another drug that also contains bupropion
  • Have used a monoamine oxidase inhibitors (MAOIs), another type of antidepressant, in the past 14 days

Be Cautious With Certain Conditions    TOP

Certain conditions can affect whether it is safe for you to take bupropion. Tell your doctor about your medical history and if you have any health problems, especially if you have:

Other conditions that are important to let your doctor know about include current or history of:

If you are woman who is pregnant or breastfeeding, be sure to talk to your doctor about whether it is safe for you to take bupropion.

Proper Usage    TOP

Start taking bupropion 1-2 weeks before you plan to stop smoking. This will give the medication enough time to reach adequate levels in your body.

Note: Do not double the dose. Taking too much bupropion at one time can cause serious reactions, including seizures.

If all goes well and you are successful in quitting, you should plan to keep taking bupropion for 7-12 weeks. Your doctor may advise staying on treatment for 6 months after quitting, depending on your circumstances.

Possible Side Effects    TOP

Most people do not have side effects from taking bupropion for smoking cessation. If side effects do occur, they can usually be minimized. In addition, side effects are most often temporary, lasting only as long as you are taking the medication.

There are rare, but serious side effects that you should be aware of. Medications like bupropion may cause severe mood and behavior changes in some people, including suicidal thoughts. Young adults may be more at risk for these side effects. Make sure you call emergency medical services right away if this happens to you.

Other Side Effects

Common side effects may include:

  • Rapid heartbeat
  • Rash, itchy skin, hives
  • Constipation
  • Muscle pain
  • Confusion
  • Lightheadedness
  • Headache
  • Insomnia
  • Trembling or shaking
  • Menstrual changes in women
  • Sore throat

More serious, but less common side effects may include:

  • Irregular heartbeat
  • Serious allergic reaction known as anaphylaxis
  • Seizures
  • Depression

Symptoms of an Overdose

Symptoms of an overdose may be more severe than side effects seen at regular doses, or 2 or more side effects may occur together. Call for emergency medical services right away if you notice any of the following:

  • Seizures
  • Fast heartbeat
  • Hallucinations
  • Loss of consciousness
  • Nausea and/or vomiting

Drug Interactions    TOP

Combining bupropion with other medications can increase your risk of seizures, as well as other potentially dangerous interactions. Examples of medications that can cause problems include:

  • Antidepressants
  • MAOIs
  • Antipsychotic medications
  • Anti-arrhythmic agents
  • Beta-blockers
  • Benzodiazepines
  • Corticosteroids
  • Theophylline

There are many other medications that may interact with bupropion. Be sure to discuss any other medications that you are taking with your doctor.

Smoking Cessation Success    TOP

It is clear from all of the studies on smoking cessation that your chance of long-term success depends a great deal on your motivation and commitment to quitting, regardless of which therapy you choose.

RESOURCES:

American Lung Association
http://www.lung.org

Smokefree—National Institutes of Health
http://smokefree.gov

CANADIAN RESOURCES:

Canadian Cancer Society
http://www.cancer.ca

The Lung Association
http://www.lung.ca

REFERENCES:

Treatment for tobacco use. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T905141/Treatment-for-tobacco-use. Updated December 25, 2017. Accessed January 9, 2018.

Bupropion hydrochloride. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T233485/Bupropion-hydrochloride. Updated January 8, 2018. Accessed January 9, 2018.

Prescription medicine: bupropion (Wellbutrin SR, Zyban). Respiratory Health Association website. Available at:
...(Click grey area to select URL)
Accessed January 9, 2018.

Roddy E. Bupropion and other non-nicotine pharmocotherapies. BMJ. 2004; 328(7438): 509-511.



Last reviewed January 2018 by EBSCO Medical Review BoardMichael Woods, MD, FAAP
Last Updated: 1/6/2016

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