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(Malignant Hepatoma; Hepatocellular Carcinoma; Primary Liver Cancer)
The liver is located in the right side of the abdomen. It stores and metabolizes nutrients. It also filters and stores blood. Liver cancer is the growth of cancer cells in the liver.
Cancer occurs when cells in the body divide without control or order. Normally, cells divide in a regulated manner. If cells keep dividing uncontrollably when new cells are not needed, a mass of tissue forms, called a growth or tumor. The term cancer refers to malignant growths. These growths can invade nearby tissues. Cancer that has invaded nearby tissues can then spread to other parts of the body.
It is not clear exactly what causes these problems in the cells, but it is probably a combination of genetics and environment.
Risk Factors TOP
Liver cancer is more common in men, and in people over 40 years old. Other factors that may increase your chances of liver cancer:
Symptoms of liver cancer in the early stages are vague. They often go unnoticed.
Liver cancer can cause the following symptoms:
Your doctor will ask about your symptoms and medical history. A physical exam will be done.
Your bodily fluids may be tested. This can be done with:
Imaging tests evaluate the liver and other structures. These may include:
The physical exam combined with all of your test results, will help to determine the stage of cancer you have. Staging is used to guide your treatment plan. Like other cancers, liver cancer is staged from I-IV. Stage I is a very localized cancer, while stage IV indicates a spread to other parts of the body.
Surgery is the only procedure used to try to cure liver cancer. Chemotherapy and radiation therapy can reduce symptoms associated with the cancer. They are not considered able to cure liver cancer by themselves.
To help reduce your chances of liver cancer:
American Cancer Society
American Liver Foundation
BC Cancer Agency
Canadian Cancer Society
Embolization therapy for liver cancer. American Cancer Society website. Available at: https://www.cancer.org/cancer/liver-cancer/treating/embolization-therapy.html. Updated April 28, 2016. Accessed October 9, 2017.
General information about adult primary liver cancer. National Cancer Institute website. Available at: https://www.cancer.gov/types/liver/patient/adult-liver-treatment-pdq. Accessed October 2, 2016. Accessed October 9, 2017.
Hepatocellular carcinoma. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T113622/Hepatocellular-carcinoma . Updated May 31, 2017. Accessed October 9, 2017.
Liver cancer. American Cancer Society website. Available at: https://www.cancer.org/cancer/liver-cancer.html. Accessed October 9, 2017.
Salem, R, Lewandowski, RJ, Mulcahy, MF, et al. Radioembolization for hepatocellular carcinoma using Yttrium-90 microspheres: a comprehensive report of long-term outcomes. Gastroenterology. 2010;138(1):52-64.
3/17/2014 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com/topics/dmp~AN~T113622/Hepatocellular-carcinoma : Luo J, Yang Y, Liu J, et al. Systematic review with meta-analysis: Meat consumption and the risk of hepatocellular carcinoma. Aliment Pharmacol Ther. 2014;39(9):913-922.
12/15/2014 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com/topics/dmp~AN~T113622/Hepatocellular-carcinoma : Yang Y, Zhang D, Feng N, et al. Increased intake of vegetables, but not fruit, reduces risk for hepatocellulr carcinoma: A meta-analysis. Gastroenterology. 2014;147(5):1031-1042.
3/11/2015 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com/topics/dmp~AN~T113622/Hepatocellular-carcinoma : Lee YJ, Lee JM, Lee JS, et al. Hepatocellular carcinoma: Diagnostic performance of multidetector CT and MR imaging—a systematic review and meta-analysis. Radiology, 2015;275(1):97-109.
10/19/2015 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com/topics/dmp~AN~T113622/Hepatocellular-carcinoma : Silverberg MJ, Lau B, et al. Cumulative incidence of cancer among persons with HIV in North America: a cohort study. Ann Intern Med. 2015 Oct 6;163(7):507-518.
Last reviewed September 2018 by
EBSCO Medical Review Board
Mohei Abouzied, MD, FACP
2545 Park Plaza
Telephone: (615) 344-6060
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