Cynthia M. Johnson, MA
Peripheral neuropathy is damage to the nerves that connect the spinal cord to the rest of the body.
Peripheral Nerves of the Foot
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Nerve damage may be from:
nerve compression or inflammation
- Some medicines, such as chemotherapy treatments for cancer
- Lacking some vitamins
Exposure to toxins and heavy metals, such as
mercury, or pesticides
- Exposure to cold or radiation
Alcohol use disorder
Health problems that can damage these nerves are:
Risk Factors TOP
Having certain health problems may raise the chance of getting peripheral neuropathy.
Damage may cause sensory and motor problems in the arms, hands, legs, and feet. Other parts of the body may also have problems. It depends on which nerves are affected.
Problems may be mild and then get worse over time. They may be worse at night. A person may have:
- Numbness or lack of feeling
- Pain, often a burning or sharp, or cutting feeling
- Sensitivity when touched
- Muscle spasms
- Muscle weakness
- Problems walking
- Loss of coordination or balance
The doctor will ask about your symptoms and health history. A physical exam will be done.
Blood and urine tests will be done.
Your nerves will be tested. This can be done with:
Images may be taken. This can be done with:
Other tests may be:
Treatment depends on what is causing the neuropathy. This can ease symptoms or make them go away. Other treatment options may be:
Exercises may be given to help with flexibility. It may help make walking easier.
Pain medicine is often used. Botulinum toxin A injections may also ease pain.
Medicines used to treat
and prevent seizures can
ease some symptoms.
People with severe problems may need:
- IV immunoglobulins to suppress the immune system
Plasma exchange of the blood to ease swelling and suppress the immune system
Manage chronic health problems, such as diabetes. This may prevent some forms of peripheral neuropathy.
American Chronic Pain Association
The Neuropathy Association
Canadian Diabetes Association
Barrell K, Smith AG. Peripheral Neuropathy. Med Clin North Am. 2019 Mar;103(2):383-397.
Peripheral neuropathy fact sheet.
National Institute of Neurological Disorders and Stroke website. Available at:
https://www.ninds.nih.gov/disorders/patient-caregiver-education/fact-sheets/peripheral-neuropathy-fact-sheet. Updated August 13, 2019. Accessed October 16, 2019.
Peripheral neuropathy. EBSCO DynaMed website. Available at:
https://www.dynamed.com/condition/peripheral-neuropathy. Updated February 19, 2019. Accessed October 16, 2019.
12/1/2016 DynaMed Plus Systematic Literature Surveillance
: Attal N, de Andrade DC, et al. Safety and efficacy of repeated injections of botulinum toxin A in peripheral neuropathic pain (BOTNEP): a randomized, double-blind, placebo-controlled trial. Lancet Neurol. 2016 May;15(6):555-565.
Last reviewed September 2019 by
EBSCO Medical Review Board
Rimas Lukas, MD
Last Updated: 10/16/2019