Radiation Therapy for Multiple Myeloma

Radiation therapy is a way to treat cancer. External beam radiation comes from a machine outside of the body. Short bursts of x-rays are aimed at tumors inside the body.

Radiation may be used to treat problem areas if chemotherapy does not work. It may be used to:

  • Ease problems caused by a tumor that returns to one site
  • Treat one plasmacytoma, a type of tumor that grows in the soft tissue or bones
  • Treat collapsed bones in the spine that cause numbness, tingling, or weak muscles
  • Clear the body of all cancer before a transplant

Radiation can also be used to ease bone pain. But, it can also cause more damage to the bones and bone marrow. This treatment may not be helpful for everyone.



Michels TC, Petersen KE. Multiple myeloma: Diagnosis and treatment. Am Fam Physician. 2017;95(6):373-383A.
Multiple myeloma. EBSCO DynaMed website. Available at: http://www.dynamed.com/topics/dmp~AN~T116888/Multiple-myeloma. Updated March 29, 2019. Accessed May 2, 2019.
Multiple myeloma. Merck Manual Professional Version website. Available at: https://www.merckmanuals.com/professional/hematology-and-oncology/plasma-cell-disorders/multiple-myeloma. Updated May 2018. Accessed May 2, 2019.
Radiation therapy. Leukemia & Lymphoma Society website. Available at: https://www.lls.org/disease-information/myeloma/treatment/radiation-therapy. Accessed May 2, 2019.
Radiation therapy for multiple myeloma. American Cancer Society website. Available at: https://www.cancer.org/cancer/multiple-myeloma/treating/radiation.html. Updated February 28, 2018. Accessed May 2, 2019.
Treatment option overview. National Cancer Institute website. Available at: https://www.cancer.gov/types/myeloma/patient/myeloma-treatment-pdq#_46. Updated April 9, 2019. Accessed May 2, 2019.
Last reviewed March 2019 by EBSCO Medical Review Board Mohei Abouzied, MD, FACP
Last Updated: 5/2/2019

EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

To send comments or feedback to our Editorial Team regarding the content please email us at healthlibrarysupport@ebsco.com. Our Health Library Support team will respond to your email request within 2 business days.