OxerutinsIntroductionOxerutins are a group of compounds that are taken from plants and fungus. They have been used to improve blood flow and vein function to ease swelling. Oxerutins can be taken as a pill or powder. Dosages1 to 2 grams daily What Research ShowsMay Be Effective
May Not Be Effective
Not Enough Data to Assess
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process. Safety NotesIt is likely safe to take oxerutins in small doses for a short time. Not enough studies have been done to say whether they are safe to use for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding. Interactions Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse. References►A. Chronic venous insufficiency A1. Petruzzellis V, Troccoli T, et al. Oxerutins (Venoruton): efficacy in chronic venous insufficiency—a double-blind, randomized, controlled study. Angiology. 2002;53(3):257-263. A2. Cesarone MR, Belcaro G, et al. Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency. Angiology. 2006;57(2):131-138. A3. Akbulut B. Calcium dobesilate and oxerutin: effectiveness of combination therapy. Phlebology. 2010 Apr;25(2):66-71. A4. Aziz Z, Tang WL, et al. A systematic review of the efficacy and tolerability of hydroxyethylrutosides for improvement of the signs and symptoms of chronic venous insufficiency. J Clin Pharm Ther. 2015 Apr;40(2):177-185. A5. Martinez-Zapata MJ, Vernooij RW, et al. Phlebotonics for venous insufficiency. Cochrane Database Syst Rev. 2016 Apr 6;4:CD003229. B. Lymphoedema B1. Badger C, Preston N, et al. Benzo-pyrones for reducing and controlling lymphoedema of the limbs. Cochrane Database Syst Rev. 2004;(2):CD003140. C. Post-Thrombotic Syndrome C1. Morling JR, Broderick C, et al. Rutosides for treatment of post-thrombotic syndrome. Cochrane Database Syst Rev. 2018 Nov 8;11:CD005625. D. Pregnancy Support D1. Smyth RM, Aflaifel N, et al. Interventions for varicose veins and leg oedema in pregnancy. Cochrane Database Syst Rev. 2015 Oct 19;(10):CD001066. E. Venous Leg Ulcers E1. Scallon C, Bell-Syer SE, et al. Flavonoids for treating venous leg ulcers. Cochrane Database Syst Rev. 2013 May 31;(5):CD006477. Last reviewed February 2020 by EBSCO NAT Review Board
Eric Hurwitz, DC Last Updated: 6/17/2020 | |
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