Citrus bioflavonoids are compounds found in citrus fruits like tangerines, oranges, and grapefruit. They come in combinations or can be taken individually. Citrus bioflavonoids have been used to improve blood flow and ease swelling in the body. They can be taken as a pill or powder. Citrus bioflavonoids can also be applied to the skin as a cream. They have been used to fight signs of aging.
500 milligrams 1 to 2 time daily
What Research Shows
May Be Effective
May Not Be Effective
Unlikely to Be Effective
Not Enough Data to Assess
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
It is likely safe to use citrus bioflavonoids on the skin and to take them orally in small doses for a short time. Not enough studies have been done to say whether it is safe to use for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding.
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.
A1. Giannini I, Amato A, et al. Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial. Tech Coloprotocol. 2015;19(6):339-345.
B1. Homayouni F, Haidari F, et al. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled trial. Phytother Res. 2018;32(6):1073-1079.
C. Radicular Pain
C1. Wang Y, Fang W, et al. A Randomized Controlled Trial Evaluating the Effects of Diosmin in the Treatment of Radicular Pain. Biomed Res Int. 2017;6875968.
D. Lipid Profile and Blood Pressure
D1. Mohammadi M, Ramezani-Jolfaie N, et al. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials. Phytother Res. 2019 Mar;33(3):534-545.
D2. acchio A, Prencipe R, et al. Effectiveness and safety of a product containing diosmin, coumarin, and arbutin (Linfadren®) in addition to complex decongestive therapy on management of breast cancer-related lymphedema. Support Care Cancer. 2019 Apr;27(4):1471-1480.
E. Bone Loss in Postmenopausal Women
E1. Martin BR, McCabe GP, et al. Effect of Hesperidin With and Without a Calcium (Calcilock) Supplement on Bone Health in Postmenopausal Women. J Clin Endocrinol Metab. 2016 Mar;101(3):923-927.
F. Diabetic Cystoid Macular Edema Without Macular Thickening
F1. Forte R, Cennamo G, et al. Long-term follow-up of oral administration of flavonoids, Centella asiatica and Melilotus, for diabetic cystoid macular edema without macular thickening. J Ocul Pharmacol Ther. 2013 Oct;29(8):733-737.
G. Senile Purpura
G1. Berlin JM, Eisenberg DP, et al. A randomized, placebo-controlled, double-blind study to evaluate the efficacy of a citrus bioflavanoid blend in the treatment of senile purpura. J Drugs Dermatol. 2011 Jul;10(7):718-722.
H. High Cholesterol
H1. Demonty I, Lin Y, et al. The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. J Nutr. 2010 Sep;140(9):1615-1620.
Last reviewed March 2020 by EBSCO NAT Review Board Eric Hurwitz, DC
Last Updated: 6/29/2020
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