Betaine Hydrochloride

Supplement Forms/Alternate Names:

Betaine HCL; trimethylglycine


Betaine hydrochloride is found in some foods and plants. It can be taken as a pill. It has been used to help produce stomach acid.


There are no advised doses for betaine hydrochloride.

What Research Shows

Not Enough Data to Assess

  • Dry mouth A1

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take betaine hydrochloride for a short time. Not enough studies have been done to say whether it is safe to use for a long period.


Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.



A1. López-Jornet P, Camacho-Alonso F, et al. Evaluation of the clinical efficacy of a betaine-containing mouthwash and an intraoral device for the treatment of dry mouth. J Oral Pathol Med. 2012 Mar;41(3):201-206.

Last reviewed July 2019 by EBSCO NAT Review Board Eric Hurwitz, DC
Last Updated: 9/9/2019

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