Amyotrophic Lateral Sclerosis
(ALS; Lou Gehrig Disease; Motor Neuron Disease)
by Cynthia M. Johnson, MA
Amyotrophic lateral sclerosis (ALS) is a disease of the nervous system. It leads to the damage of nerve cells in the brain and spine. These nerves control muscle movement. People with ALS have muscles that weaken and shrink as the disease worsens.
The exact cause is not known. Genes and the environment may play a role.
ALS is more common in men and in people who are 50 to 75 years of age. Other things that may raise the risk are:
The first symptoms of ALS may be:
Problems worsen over time and result in:
You will be asked about your symptoms and your personal and family health history. A physical exam will be done. There are no tests to diagnose ALS.
Tests will be done to rule out other health issues that cause similar problems. These may be:
The care team will consider a person's symptoms and test results before making a diagnosis. A second opinion with a nerve specialist may help to confirm the diagnosis.
There is no cure. The goal is to manage symptoms. Options are:
Some medicines may help to slow the disease. Others may be used to:
A team of specialists will work with you to create a care plan. The team will focus on quality of life for you and your family.
ALS will affect muscles throughout the body. Chewing, swallowing, speech, and breathing can all be affected. Care will help to support the body when these changes occur. Options are:
There are no known guidelines to prevent this health problem.
National Institute of Neurological Disorders and Stroke
Amyotrophic Lateral Sclerosis Society of British Columbia
Amyotrophic lateral sclerosis. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/amyotrophic-lateral-sclerosis-als. Accessed July 19, 2021.
Amyotrophic lateral sclerosis (ALS) fact sheet. National Institute of Neurological Disorders and Stroke website. Available at: https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Amyotrophic-Lateral-Sclerosis-ALS-Fact-Sheet. Accessed July 16, 2021.
Brent JR, Ajroud-Driss S. Amyotrophic lateral sclerosis: Integrated care provides the best quality of life. Pract Neurol (Fort Wash Pa) . Jul-Aug 2019;18:46-49.
Brent JR, Franz CK, et al. ALS: management problems. Neurol Clin. 2020;38(3):565-575.
What is ALS? ALS Association website. Available at:
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Accessed July 16, 2021.
9/26/2017 EBSCO DynaMed Systematic Literature Surveillance. Available at: https://www.dynamed.com/condition/amyotrophic-lateral-sclerosis-als: US Food and Drug Administration. FDA approves drug to treat ALS. Available at: https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm557102.htm. Accessed September 26, 2017.
Last reviewed July 2021 by EBSCO Medical Review Board Rimas Lukas, MD
Last Updated: 7/16/2021
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