Eosinophilic gastroenteritis (EGE) is the buildup of white blood cells called eosinophils. It causes inflammation in the stomach and lining of the intestines. This can lead to tissue damage, ulcers, and polyps. It can also make it difficult to absorb nutrients from food.
Eosinophils are part of the immune system. They should only respond to an infection or injury. These cells release a chemical that causes inflammation. With EGE, the inflammation starts or continues even though it is not needed. Over time this can lead to tissue damage, ulcers, and polyps in the colon.
It is not clear what causes EGE. It is likely a blend of gene defects and the environment. It may also be linked to an allergic reaction.
Factors that may increase your child’s chances of EGE include:
You will be asked about your child’s symptoms and past health. A physical exam will be done. EGE is hard to diagnose with simple tests. Some tests may be able to rule out other conditions with similar symptoms.
About eosinophilic gastroenteritis (EGE). The Southeast Eosinophilic Disease Center of Atlanta, Inc. website. Available at: https://www.seedcenteratl.org/about-eosinophilic-gastroenteritis-ege. Accessed January 28, 2021.
Eosinophilic gastroenteritis. American Partnership for Eosinophilic Disorders website. Available at: http://apfed.org/about-ead/egids/ege. Accessed January 28, 2021.
Shih HM, Bair MJ, Chen HL, Lin IT. Eosinophilic Gastroenteritis : Brief Review. Acta Gastroenterol Belg. 2016 Apr-Jun;79(2):239-44.
Uppal V, Kreiger P, Kutsch E. Eosinophilic Gastroenteritis and Colitis: a Comprehensive Review. Clin Rev Allergy Immunol. 2016 Apr;50(2):175-88.
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