The doctor will ask about your symptoms and health history. You will be asked whether your parents or another family member has or had CADASIL or early onset strokes, dementia, seizures, or migraines. A physical exam will be done.
Images may be taken of the brain. This can be done with an
These tests will be done to look for signs of the NOTCH3 gene:
Bersano A, Bedini G, Oskam J, et al. CADASIL: treatment and management options. Curr Treatment Options Neurol. 2017;19(9):31.
Brass SD, Smith EE, et al. Case records of the Massachusetts General Hospital. Case 12-2009. A 46-year-old man with migraine, aphasia, and hemiparesis and similarly affected family members. N Engl J Med. 2009 Apr 16;360(16):1656-1665.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy-cadasil. Accessed January 25, 2021.
Migraine in adults EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/migraine-in-adults. Accessed January 25, 2021.
Stroke rehabilitation. EBSCO DynaMed website. Available at: https://www.dynamed.com/management/stroke-rehabilitation-in-adults. Accessed January 25, 2021.
What is CADASIL? CADASIL Foundation website. Available at: http://cadasilfoundation.org/what.html. Accessed January 25, 2021.
Last reviewed December 2020 by
EBSCO Medical Review Board
Rimas Lukas, MD
Last Updated: 1/25/2021
EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
To send comments or feedback to our Editorial Team regarding the content please email us at email@example.com. Our Health Library Support team will respond to your email request within 2 business days.