Bevacizumab injection and bevacizumab-awwb injection are biologic medications (medications made from living organisms). Biosimilar bevacizumab-awwb injection is highly similar to bevacizumab injection and work the same way as bevacizumab injection in the body. Therefore, the term bevacizumab injection products will be used to represent these medications in this discussion.
WHY is this medicine prescribed?
Bevacizumab injection products are used with chemotherapy to treat cancer of the colon (large intestine) or rectum that has spread to other parts of the body. Bevacizumab injection products are also used with chemotherapy to treat certain types of lung cancer. Bevacizumab injection products are also used to treat glioblastoma (a certain type of cancerous brain tumor) that has not improved or has come back after treatment with other medications. Bevacizumab injection products are also used in combination with another medication to treat renal cell cancer (RCC, a type of cancer that begins in the kidney) that has spread to other parts of the body. Bevacizumab injection products are also used with chemotherapy to treat cervical cancer (cancer that begins in the opening of the uterus [womb]) that has not improved or has come back after treatment with other medications or has spread to other parts of the body. Bevacizumab injection (Avastin) is used to treat certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer that has not improved or has come back after treatment with other medications. Bevacizumab injection products are in a class of medications called antiangiogenic agents. They work by stopping the formation of blood vessels that bring oxygen and nutrients to tumors. This may slow the growth and spread of tumors.
HOW should this medicine be used?
Bevacizumab injection products come as a solution (liquid) to administer slowly into a vein. Bevacizumab injection products are administered by a doctor or nurse in a medical office, infusion center, or hospital. Bevacizumab injection products are usually given once every 2 or 3 weeks. Your dosing schedule will depend on the condition that you have, the other medications you are using, and how well your body responds to treatment.
It should take 90 minutes for you to receive your first dose of a bevacizumab injection product. A doctor or nurse will watch you closely to see how your body reacts to bevacizumab. If you do not have any serious problems when you receive your first dose of a bevacizumab injection product, it will usually take 30 to 60 minutes for you to receive each of your remaining doses of the medication.
Bevacizumab injection products may cause serious reactions during infusion of the medication. If you experience any of the following symptoms, tell your doctor immediately: difficulty breathing or shortness of breath, chills, shaking, sweating, headaches, chest pain, dizziness, feeling faint, flushing, itching, rash, or hives. Your doctor may need to slow down your infusion, or delay or stop your treatment if you experience these or other side effects.
Are there OTHER USES for this medicine?
Bevacizumab injection (Avastin) is also sometimes used to treat wet age-related macular degeneration (AMD; an ongoing disease of the eye that causes loss of the ability to see straight ahead and may make it more difficult to read, drive, or perform other daily activities). Talk to your doctor about the risks of using bevacizumab to treat your condition.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before receiving a bevacizumab injection product,
tell your doctor and pharmacist if you are allergic to bevacizumab, bevacizumab-awwb, any other medications, or any of the ingredients in bevacizumab injection products.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention anticoagulants (blood thinners) such as warfarin (Coumadin, Jantoven); and sunitinib (Sutent). Also tell your doctor if you are taking or if you have ever taken an anthracycline (a type of chemotherapy used for breast cancer and some types of leukemia) such as daunorubicin (Cerubidine), doxorubicin, epirubicin (Ellence), or idarubicin (Idamycin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you have ever been treated with radiation therapy to the left side of your chest or pelvis; and if you have or have ever had high blood pressure, or any condition that affects your heart or blood vessels (tubes that move blood between the heart and other parts of the body). Also, tell your doctor if you have recently coughed up blood.
you should know that bevacizumab injection products may cause infertility in women (difficulty becoming pregnant); however, you should not assume that you cannot get pregnant. Tell your doctor if you are pregnant or plan to become pregnant. You should use birth control to prevent pregnancy during your treatment with a bevacizumab injection product and for at least 6 months after your final dose. If you become pregnant while using a bevacizumab injection product, call your doctor. Bevacizumab may harm the fetus and increase the risk of a pregnancy loss.
tell your doctor if you are breastfeeding. You should not breastfeed during your treatment with a bevacizumab injection product and for at least 6 months after your final dose.
tell your doctor if you have recently had surgery or if you plan to have surgery, including dental surgery. If you are scheduled to have surgery, your doctor will stop your treatment with an bevacizumab injection product at least 28 days before the surgery. If you have recently had surgery, you should not receive an bevacizumab injection product until at least 28 days have passed and until the area has completely healed.
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do IF I FORGET to take a dose?
If you miss an appointment to receive a dose of a bevacizumab injection product, call your doctor as soon as possible.
What SIDE EFFECTS can this medicine cause?
Bevacizumab injection products may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
loss of appetite
change in ability to taste food
sores on the skin or in the mouth
increased or decreased tears
stuffy or runny nose
muscle or joint pain
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
nosebleeds or bleeding from your gums; coughing up or vomiting blood or material that looks like coffee grounds; unusual bleeding or bruising; increased menstrual flow or vaginal bleeding; pink, red, or dark brown urine; red or tarry black bowel movements; or headache, dizziness, or weakness
slow or difficult speech
weakness or numbness of an arm or leg
pain in the arms, neck, jaw, stomach, or upper back
shortness of breath
change in vision or loss of vision
sore throat, fever, chills, and other signs of infection
swelling of the face, eyes, stomach, hands, feet, ankles, or lower legs
unexplained weight gain
pain, tenderness, warmth, redness, or swelling in one leg only
redness, itching, or scaling of the skin
stomach pain, constipation, nausea, vomiting, shivering, or fever
Bevacizumab injection products may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( Web Site ) or by phone (1-800-332-1088).
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at Web Site. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What OTHER INFORMATION should I know?
Keep all appointments with your doctor. Your doctor will check your blood pressure and test your urine regularly during your treatment with a bevacizumab injection product.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
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