Non-Hodgkin lymphoma is a cancer of the lymphatic system. The lymphatic system is a series of tubes and nodes that run through the body. It contains a fluid that helps fight infections and moves waste out of the body.
This cancer starts in a type of lymph cell called a lymphocyte. These cells spread throughout the lymph system. Over time, the cells will make it harder for a child's body to fight infections.
This cancer is different from
Hodgkin lymphoma. This is another type of cancer that affects the lymphatic system.
Treatment depends on the stage of the disease. The stage is determined by how far the cancer has spread and what organs are affected.
Chemotherapy and Radiation Therapy
is the use of drugs to kill cancer cells. The drugs enter the bloodstream and travel through the body killing mostly cancer cells. With
radiation therapy, radiation is aimed at a specific area to kill the cancer cells. Some children may have both chemotherapy and radiation.
Treatment and the cancer itself can damage blood and lymph cells. Transplantation will help the body rebuild these cells. Choices are:
Bone marrow transplantation—Bone marrow is removed, treated, and frozen. Large doses of chemotherapy and/or radiation therapy are applied to kill the cancer cells. After treatment, the bone marrow is replaced via a vein. Bone marrow from a healthy donor is also sometimes used.
Peripheral blood stem cell transplantation—Stem cells are removed from the blood before chemotherapy or radiation treatment. After treatment is done, the stem cells are then placed back into the blood.
These medicines increase or restore the body’s natural defenses against cancer. Sometimes a drug or antibody that is directed at the lymphoma is linked to a radioactive substance. It will deliver a focused dose of radiation to the tumor.
There is no known way to prevent this form of cancer.
Bowzyk Al-Naeeb A, Ajithkumar T, et al. Non-Hodgkin Lymphoma. BMJ. 2018 Aug 22;362:k3204.
Non-Hodgkin lymphoma in children. American Cancer Society website. Available at: http://www.cancer.org/Cancer/Non-HodgkinLymphomainChildren/DetailedGuide/non-hodgkin-lymphoma-in-children-non-hodgkin-lymphomain-children. Accessed September 21, 2020.
Non-Hodgkin lymphoma (HL). EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/non-hodgkin-lymphoma-nhl. Accessed September 21, 2020.
Non-Hodgkin’s lymphoma (NHL). Children’s Hospital of Wisconsin website. Available at: https://www.chw.org/medical-care/macc-fund-center/conditions/oncology/non-hodgkins-lymphoma-nhl. Accessed September 21, 2020.
Last reviewed March 2020 by
EBSCO Medical Review Board
Kari Kassir, MD
Last Updated: 4/13/2021
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