Von Hippel-Lindau disease (VHL) is a rare disorder in which some blood vessels grow in an unusual way. This causes tumors in parts of the body that have many blood vessels.
VHL is caused by an abnormal change in a gene. Blood vessels grow in a small knot instead of in branches. The knot forms a growth or tumor, often in the eye and brain. VHL is also linked to other tumors and cysts throughout the body.
The risk of this problem is higher in people who have other family members who have it.
Symptoms differ in each person. It can start at any age, in different organs, and can cause mild-to-severe problems.
Frantzen C, Klasson TD, et al. von Hippel-Lindau Syndrome GeneReviews 2015 Aug 6.
Gläsker S, Neumann HPH, et al. Von Hippel Lindau syndrome. Available at: http://www.ncbi.nlm.nih.gov/books/NBK279124. Accessed November 5, 2020.
von Hippel-Lindau disease. EBSCO DynaMed Plus website. Available at: https://www.dynamed.com/condition/von-hippel-lindau-disease. Accessed November 5, 2020.
Last reviewed September 2020 by EBSCO Medical Review Board
Kari Kassir, MD
Last Updated: 5/12/2021
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