Chronic granulomatous disease (CGD) is a rare genetic problem. White blood cells called phagocytes are not able to kill some types of bacteria and fungi. This can lead to frequent and deadly infections.
CGD is caused by one of five faulty genes. One type of CGD is x-linked, meaning the faulty gene is passed from mother to son. The other four types are recessive. This means one of the faulty genes is passed from each parent to their child.
The x-linked form of CGD is more common in males.
Symptoms usually start in early childhood. Often, a baby will have a history of frequent infections that do not respond to treatment.
Chronic granulomatous disease. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/chronic-granulomatous-disease. Accessed March 8, 2021.
Chronic granulomatous disease and other phagocytic cell disorders. Immune Deficiency Foundation website. Available at: http://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/chronic-granulomatous-disease-and-other-phagocytic-cell-disorders. Accessed March 9, 2021.
Thomsen IP, Smith MA, et al. A Comprehensive Approach to the Management of Children and Adults with Chronic Granulomatous Disease. J Allergy Clin Immunol Pract. 2016 Nov - Dec;4(6):1082-1088.
Last reviewed December 2020 by
EBSCO Medical Review Board
Kari Kassir, MD
Last Updated: 3/9/2021
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