Chemotherapy Drugs and Delivery

There are a variety of chemotherapy drugs. The choice and combination of drugs will be based on your particular cancer and reaction to drugs. Chemotherapy drugs for ovarian cancer may include:

• Carboplatin
• Cisplatin
• Paclitaxel
• Docetaxel
• Gemcitabine
• Doxorubicin
• Topotecan
• Epirubicin
• Bevacizumab

Chemotherapy is usually given by IV, but some forms can be given by mouth as well. IV chemotherapy is delivered in cycles (usually 3-6) over a set period of time. For ovarian cancer, intraperitoneal chemotherapy may be used. Drugs are delivered through a catheter and directly into the abdominal cavity. The catheter port is inserted during laparoscopy and is anchored to a bone inside the abdomen. Drugs can be injected through the skin and into the port. Generally, this method of delivery allows for the use of stronger drugs.

A medical oncologist will determine how many cycles of chemotherapy are needed and what combination of drugs will work best.

Side Effects and Management

Though the drugs are targeted to cancer cells, they can affect healthy cells as well. The death of cancer cells and impact on healthy cells can cause a range of side effects. A medical oncologist will work to find the best drug combination and dosage to have the most impact on the cancer cells and minimal side effects on healthy tissue. Side effects or complications from chemotherapy may include:

• Nausea and vomiting
• Fatigue
• Loss of appetite
• Memory or cognitive problems
• Low blood cell counts (red cells, white cells, or platelets) that can lead to infection or bleeding
• Premature menopause —including symptoms and loss of fertility

A variety of treatments are available to help manage side effects including medication, lifestyle changes, and alternative treatments. In some cases, the chemotherapy regimen may be adjusted to reduce severe side effects. The earlier the side effects are addressed, the more likely they will be controlled with a minimum of discomfort.