Diseases that result in destruction of blood cells or bone marrow
Side effects of certain medications such as chemotherapy for cancer
Problems from the procedure are rare, but all procedures have some risk. Your doctor will review potential problems, like:
Severe reactions due to allergies, volume overload, iron build up, and the mismatching of blood types. Hospitals have several steps to make sure blood is correctly matched.
Certain infections such as hepatitis or
HIV, can be passed on during blood transfusions. There are many steps and tests that are done to thoroughly check donated blood before anyone is allowed to receive it.
What to Expect
Prior to Procedure
You will have a blood test to determine your specific blood type. The donor blood will be carefully matched to your blood type.
You may also be given a physical exam. Your vital signs, including your temperature, heart rate, breathing rate, and blood pressure, will be recorded.
You may be given medications before you receive a transfusion. These drugs will help reduce any minor allergic reactions.
Description of the Procedure
You will need to be seated. A bag containing the blood product will be hung nearby. An IV needle will be placed into a vein in your hand or arm. The blood product will drip slowly from the bag through a tube into your vein. After the bag of blood product is empty, the needle in your arm will be removed.
Throughout the transfusion, your vital signs will be checked regularly. You will also be asked about pain, itching, or discomfort. Most reactions occur early in a blood transfusion, so you will be monitored more closely during the first 15 minutes.
How Long Will It Take?
About 2–4 hours
Will It Hurt?
The placement of the IV needle is uncomfortable. After the needle is in place, it should not cause pain.
At the Care Center
Immediately following your procedure, the staff may:
Monitor you closely.
Give you pecific instructions based on your overall condition.
Order blood tests to determine how effective the transfusion was.
When you return home after the transfusion, carefully follow your doctor’s advice regarding any activity restrictions or other
Blood transfusion. National Heart Lung and Blood Institute website. Available at: https://www.nhlbi.nih.gov/health-topics/blood-transfusion. Accessed March 23, 2018.
Hladik W, Dollard SC, Mermin J, et al. Transmission of human herpesvirus 8 by blood transfusion. N Engl J Med. 2006;355(13):1331-1338.
Posthouwer D, Fischer K, van Erpecum KJ, Mauser-Bunschoten EP.. The natural history of childhood-acquired hepatitis C infection in patients with inherited bleeding disorders. Transfusion. 2006;46(8):1360-1366.
The process. American Red Cross website. Available at: https://www.redcrossblood.org/learn-about-blood/blood-transfusions/the-process. Accessed March 23, 2018.
Last reviewed March 2018 by
EBSCO Medical Review Board
Marcin Chwistek, MD
Last Updated: 5/1/2014
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