The cause of psoriasis is unclear. Signals from a defect in the immune system may result in an overgrowth of skin cells. Because the cells grow faster than they can be shed, they pile up on the skin's surface. The excess skin cells are thought to cause the silvery white scales that are characteristic of plaque-type psoriasis.
Factors that may increase the chances of psoriasis:
Family history of psoriasis
Certain bacterial infections
Certain medications such as beta blockers, tumor necrosis factor-alpha inhibitors, and lithium
Suppression of the immune system
The red, thickened, and rough patches of psoriasis may occur anywhere, but are commonly found on the scalp, elbows, knees, palms, and soles. Other symptoms include:
Silvery white scales
Pitted or dented fingernails and/or toenails
Red lesion or rashes in folds of skin
Joint pain suggesting
The skin may also be sore, burning, or itchy depending on the type of psoriasis.
The rashes and lesions may come and go.
You will be asked about your symptoms and medical history. A physical exam will be done. It will include an exam of your skin and nails. There are no specific blood tests or diagnostic procedures for psoriasis. Sometimes a skin biopsy will be done to confirm the diagnosis.
Treatment is based on:
The severity of the disease
The extent and location of the areas involved
Any associated symptoms such as arthritis
Many patients respond well to treatments applied directly to the skin. Topical treatments include:
Corticosteroid creams and ointments (most common treatment)
Tacrolimus and pimecrolimus (especially for inverse psoriasis)
Photo (Light) Therapy
If psoriasis covers more than 10% of the body, it is difficult to treat with topical medications alone. Daily, short, nonburning exposure to sunlight clears or improves psoriasis in many people. Sunlight is often included among initial treatments.
A more controlled form of artificial light treatment (UVB phototherapy) is often used in cases that are more widespread. Alternatively, psoriasis can be treated with ultraviolet A (UVA light) and psoralen. Psoralen is an oral or topical medication that makes the body more sensitive to light. This treatment is known as PUVA.
can be very effective in controlling psoriasis, but it requires frequent treatments. It may cause side effects such as nausea, headache, and fatigue, burning, and itching. Both UVB and PUVA may increase the person's risk for
For more severe types of psoriasis, doctors may prescribe a number of other powerful medications, which can be effective, but are associated with side effects that are more serious. These include:
Methotrexate—A type of systemic medication that affects the whole immune system. It should not be taken by pregnant women, women planning to become pregnant, or by their male partners.
Cyclosporine—Another type of systemic medication that suppresses the immune system to slow the turnover of skin cells. It should not be taken by pregnant or breastfeeding women.
Hydroxyurea—Less toxic than methotrexate or cyclosporine, but may be less effective.
Systemic retinoids—Compounds with vitamin A-like properties taken internally may be prescribed in severe cases. Retinoids can cause birth defects, and women must protect themselves from pregnancy for several years after completing treatment.
Systemic retinoids are often combined with phototherapy for increased effectiveness and for their property of being protective against squamous skin cancer.
Newer medications include biologic agents such as adalimumab, etanercept, and infliximab, which affect a part of the body's immune response by targeting certain cells in the immune system that cause inflammation.
Avoiding physical trauma to the skin, infections, and cold, dry temperatures may help reduce flare-ups in people with the condition.
Moderate to severe psoriasis and psoriatic arthritis: biologic drugs. National Psoriasis Foundation website. Available at: https://www.psoriasis.org/about-psoriasis/treatments/biologics. Accessed March 6, 2018.
Psoriasis. American Academy of Dermatology website. Available at: https://www.aad.org/public/diseases/scaly-skin/psoriasis. Accessed March 6, 2018.
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