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Supplements: To Take or Not to Take, That Is the Question

Image for HCA vitamins article Around 400 BC, the celebrated Greek physician Hippocrates offered some advice about diet and health. He declared, "Let food be thy medicine and medicine be thy food." The growing number of Americans who turn to supplements to make up for a poor diet ought to pay attention to those words of wisdom.

Each day, millions of adults in the United States take high doses of vitamins and minerals with hopes of feeling better, getting sick less often, and living longer. For years, physicians told consumers that, at worst, they were just wasting their money. But now, the word is to be careful—because high doses of certain vitamins and minerals may actually increase the risk of disease.

Dietary Supplements 101

As you probably already know, vitamins—by far the most popular choice of supplement—are vital to our survival. The body cannot make them on its own, so we must get vitamins from our diet. Similarly, we need minerals like iron and calcium to function, and must rely on outside sources to meet our requirements. Other supplements, such as herbs, are a whole other story.

Although supplements are a good idea in certain cases (such as for pregnant women, the elderly, and vegetarians), experts agree the best way for you to get the nutrients you need is by eating a well-balanced, healthful diet.

Too Much of a Good Thing

One hundred years ago, scientists began to identify the nutrients in foods that we need to avoid getting deficiency diseases like beriberi and rickets. With attention being given to the benefits of vitamins and minerals, it’s no wonder that many of us choose to take supplements. Problems arise, however, when people take individual vitamins or minerals in excessive amounts, rather than eat a nutritious diet.

Use the following chart as a guide:

Supplements: Recommended Intake Levels of Some Supplements and Known Risks Associated With Excessive Amounts

Vitamin or MineralWhy You Need It Recommended Dose Per Day (for adults, ages 19-50) Tolerable Upper Intake Level (UL)What Happens if You Take Too Many VitaminsGood Food Sources
Vitamin AVision, growth, and immune function900 micrograms (µg) for men , 700 µg for women)3,000 µgToo much may cause hair loss, nausea, and vomiting, and may increase the risk of bone fracture. Very high intakes can cause liver disease and fetal malformations.Preformed vitamin A sources include fortified cereal, eggs, and dairy products; Provitamin A carotenoids (like beta-carotene), found in deep orange and dark green fruits and vegetables, such as unskinned sweet potatoes
Vitamin B6Protein metabolism, neurotransmitter formation, red blood cell function, and hormone function1.3 milligrams (mg)100 mgIf taken at very high doses, may result in painful neurologic symptoms and difficulty walking.Fortified cereals, beans, meat, poultry, fish, and some fruits and vegetables
Folic acid (folate)DNA metabolism as well as the metabolism of several important amino acids400 µg1,000 µg High doses, while safe in themselves, may mask symptoms of, the rare disease, pernicious anemia allowing it to progress unchecked. Fruits and vegetables, fortified grain foods
NiacinNecessary for energy metabolism16 mg for men, 14 mg for women35 mgIn doses fifty times higher than the tolerable upper intake level, can damage the liver and cause severe gastrointestinal problems.Meat, poultry, fish, fortified cereals, legumes, milk, and seeds
Vitamin CIt is required for the synthesis of collagen and the neurotransmitter norepinephrine90 mg for men, 75 mg for women2,000 mgGenerally safe, but at high doses can cause diarrhea and might increase risk of urinary tract stones.Citrus fruits
Vitamin DIt helps to form and maintain strong bones, plus is needed to maintain blood levels of calcium and phosphorus600 IU4000 IUContinuous very high intakes might lead to damage to the heart, blood vessels and kidneys due to calcification.Fatty fish (herring, salmon, sardines), eggs from hens that have been fed vitamin D, and fortified milk; exposure to sunlight provides another important source
IronAn essential component of hundreds of proteins involved in the transport and storage of oxygen8 mg for men, 18 mg for women45 mgCan poison a child, causing nausea, vomiting, lethargy, fever, difficulty breathing, coma, and even death; in adults excess iron is theorized to increase risk of heart disease.Lean red meats, shellfish, legumes, dried fruit, and green leafy vegetables (Note: iron from non-meat sources is best absorbed when vitamin C is also present)
SeleniumNecessary for the function of numerous enzymes55 µg400 µgToxic effects of overdosage include hair and nail brittleness and loss, gastrointestinal disturbances, skin rashes, fatigue, irritability, and nervous system abnormalities.Organ meats, seafood, and grains

The Bottom Line

While it may be promising, the evidence so far linking supplements with a reduced risk of chronic disease is much less convincing than most people realize. What is clear is just how easy it is to overdose on certain supplements. Also, many supplements may interact with medications you currently take. Therefore, your best bet is to get most of the nutrients you need from the foods you eat. For a healthful diet, be sure to include lots of fruits and vegetables, whole grains (like whole wheat bread and brown rice), unsaturated fats (found in nuts, avocados, and oils), and low-fat dairy products.

If you do take supplements, keep the following in mind:


National Institutes of Health, Office of Dietary Supplements

United States Department of Agriculture Food Safety and Inspection Service


Dietitians of Canada

Health Canada Food and Nutrition


Folate. Office of Dietary Supplements website. Available at: Updated December 14, 2012. Accessed February 17, 2016.

Iron. Office of Dietary Supplements website. Available at: Updated November 21, 2015. Accessed February 17, 2016.

Niacin. Linus Pauling Institute Oregon State University website. Available at: Accessed February 17, 2016.

Selenium. Office of Dietary Supplements website. Available at: Updated July 2, 2013. Accessed February 17, 2016.

Vitamin A. Office of Dietary Supplements website. Available at: Updated June 5, 2013. Accessed February 17, 2016.

Vitamin B3. EBSCO Natural and Alternative Treatments website. EBSCO Health Library website. Available at: Updated August 2013. Accessed February 17, 2016.

Vitamin B6. Office of Dietary Supplements website. Available at: Updated September 15, 2013. Accessed February 17, 2016.

Vitamin C. Office of Dietary Supplements website. Available at: Updated June 5, 2013. Accessed February 17, 2016.

Vitamin D. Office of Dietary Supplements website. Available at: Updated November 10, 2014. Accessed February 17, 2016.

Vitamin supplementation for cardiovascular disease prevention. EBSCO DynaMed website. Available at: Updated February 3, 2016. Accessed February 17, 2016.

Last reviewed February 2016 by Michael Woods, MD  Last Updated: 4/2/2014