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Accutane and Depression: Is There a Link?

picture of pills For several years, there has been debate over whether Accutane (isotretinoin), a drug prescribed for serious cases of acne, could be causing depression and subsequent suicide in teenagers. Though depression and suicide are serious health problems for teenagers, there has not been consistent evidence that Accutane contributes significantly to either.

Severe Acne, Low Self-Esteem, and Poor Self Image

Acne can have a significant impact on a person's outlook on life. Studies have detected that the following characteristics are common among people with acne:

These negative effects are often interrelated and can have a crippling impact on people socially, on the job, or at school. Acne medications and treatment regimens have been widely prescribed to teenagers and adults. Accutane is a medication generally used only after other treatments have not worked. It has medical risks and is particularly dangerous to a fetus if a woman taking this drug becomes pregnant. Doctors typically present these risks to those who are considering taking Accutane as part of the process of informed consent.

Depression in Adolescents

Many teenagers experience depression each year, with some meeting psychiatric criteria for major depressive disorder. Depression is a complex disease associated with multiple risk factors and is a problem in adolescents whether or not they also have acne.

Doctors treating acne (or any other adolescent disorder) need to talk to teenagers about their feelings and self-esteem. In addition to asking about feelings of depression, parents and physicians should look for common signs and symptoms of depression in adolescents. Among these are:

Is There a Link Between Depression and Accutane?

Despite the manufacturer’s warning that Accutane can cause psychiatric symptoms, there is not conclusive evidence of a relationship. Many studies have been done, but some of the studies are unclear and other studies fail to show a link.

Since there is not clear evidence on the issue, it is a good idea to be vigilant. If you are a teen taking Accutane or if you have a teen on the medication, be sure to to immediately report mood changes and symptoms of depression to the doctor. The US Food and Drug Administration (FDA) recommends that if you have any new symptoms of depression, you should stop isotretinoin and let your doctor know of your symptoms right away. These symptoms need to be promptly evaluated for appropriate treatment.


American Academy of Child & Adolescent Psychiatry

The American Academy of Dermatology


The College of Family Physicians of Canada

Public Health Agency of Canada


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Last reviewed March 2016 by Michael Woods, MD  Last Updated: 3/9/2016