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Supplement Forms/Alternate Names



Oxerutins are a group of compounds that are taken from plants and fungus. They have been used to improve blood flow and vein function to ease swelling. Oxerutins can be taken as a pill or powder.


1 to 2 grams daily

What Research Shows

May Be Effective

  • Chronic venous Insufficiency —may ease symptoms A1-A5

May Not Be Effective

  • Post-thrombotic syndrome —may not provide benefit C1

Not Enough Data to Assess

  • Lymphedema B1
  • Pregnancy Support D1
  • Venous leg ulcers E1

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take oxerutins in small doses for a short time. Not enough studies have been done to say whether they are safe to use for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding.


Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.



A. Chronic venous insufficiency

A1. Petruzzellis V, Troccoli T, et al. Oxerutins (Venoruton): efficacy in chronic venous insufficiency—a double-blind, randomized, controlled study. Angiology. 2002;53(3):257-263.

A2. Cesarone MR, Belcaro G, et al. Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency. Angiology. 2006;57(2):131-138.

A3. Akbulut B. Calcium dobesilate and oxerutin: effectiveness of combination therapy. Phlebology. 2010 Apr;25(2):66-71.

A4. Aziz Z, Tang WL, et al. A systematic review of the efficacy and tolerability of hydroxyethylrutosides for improvement of the signs and symptoms of chronic venous insufficiency. J Clin Pharm Ther. 2015 Apr;40(2):177-185.

A5. Martinez-Zapata MJ, Vernooij RW, et al. Phlebotonics for venous insufficiency. Cochrane Database Syst Rev. 2016 Apr 6;4:CD003229.

B. Lymphoedema

B1. Badger C, Preston N, et al. Benzo-pyrones for reducing and controlling lymphoedema of the limbs. Cochrane Database Syst Rev. 2004;(2):CD003140.

C. Post-Thrombotic Syndrome

C1. Morling JR, Broderick C, et al. Rutosides for treatment of post-thrombotic syndrome. Cochrane Database Syst Rev. 2018 Nov 8;11:CD005625.

D. Pregnancy Support

D1. Smyth RM, Aflaifel N, et al. Interventions for varicose veins and leg oedema in pregnancy. Cochrane Database Syst Rev. 2015 Oct 19;(10):CD001066.

E. Venous Leg Ulcers

E1. Scallon C, Bell-Syer SE, et al. Flavonoids for treating venous leg ulcers. Cochrane Database Syst Rev. 2013 May 31;(5):CD006477.

Last reviewed February 2020 by EBSCO NAT Review Board Eric Hurwitz, DC  Last Updated: 6/17/2020