Sickle cell disease is genetic. To have it, children must get 2 faulty genes—one from each parent.
The disease is most common in people of African descent. It is also more common in those with ancestors from:
Pinto VM, Balocco M, et al. Sickle cell disease: a review for the internist. Intern Emerg Med. 2019;14(7):1051-1064.
Sickle cell disease. Kids Health—Nemours Foundation website. Available at: http://kidshealth.org/en/parents/sickle-cell-anemia.html. Accessed January 29, 2021.
Sickle cell disease in adults and adolescents. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/sickle-cell-disease-in-adults-and-adolescents . Accessed March 3, 2021.
Sickle cell disease in infants and children. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/sickle-cell-disease-in-infants-and-children Accessed March 3, 2021.
Sickle cell trait. Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/ncbddd/sicklecell/traits.html. Accessed January 29, 2021.
Last reviewed March 2020 by EBSCO Medical Review Board Marcin Chwistek, MD Last Updated: 3/4/2021