Health Library Home>Wellness Centers>Aging & Health>Article

A New Face for an Old Enemy: Post-Polio Syndrome

Forty years after surviving a childhood bout of poliomyelitis (polio), 53-year-old Michael B. began experiencing a medley of uncomfortable, frightening, and debilitating symptoms. It started with an overall sense of bone-crushing fatigue, and was soon followed by joint pain and muscle weakness. Finally, when the pain and exhaustion became overwhelming, he went to his doctor, who diagnosed his problem as post-polio syndrome (PPS).

A Debilitating Disease

Polio was America's summer terror. Summer epidemics of polio ravaged the Western industrial world during the 1940s and 1950s until the development of the Salk (1955) and Sabin (1961) vaccines. The vaccines helped eradicate polio from the US by 1979.

Poliomyelitis is an infectious disease caused by a virus that enters the gastrointestinal tract, then the bloodstream, and finally the central nervous system. Infected nerves in the brain and spinal cord stop working normally, which leads to weakness or paralysis of the muscles in the arms, legs, chest, diaphragm, and throat.

Almost all of the motor nerves are affected by the poliovirus, and at least half are killed off. The remaining healthy nerve cells send out "sprouts" to reconnect the muscle fibers that were orphaned when their motor neurons were killed.

Long-Term Repercussions

Decades after the initial injury, the sprouted nerves (which have more than their normal workload) begin suffering from overuse. These overused nerves—along with overworked joints that hurt and throb after decades of doing too much work with too little muscle support—make up the condition known as post-polio syndrome (PPS). Symptoms of PPS include progression or new symptoms of:

These symptoms may be severe enough to interfere with your ability to carry out normal daily activities.

A common symptom of PPS is fatigue. Brain fatigue—the inability of polio survivors to concentrate and stay awake as the day goes on—is associated with a marked reduction in the brain-activating hormone ACTH. MRI reveals damage to the brainstem neurons responsible for activating the brain. Polio survivors may also suffer from an impaired ability to make dopamine—a brain chemical necessary for optimal nervous system functioning.

Psychological symptoms, such as chronic stress, anxiety, depression, and compulsive and Type A behavior, may also be evident in polio survivors.

Living With PPS

Polio survivors should slow activity to allow damaged neurons, joints, and muscles to rest. Management of PPS includes measures to both control and relieve existing symptoms.

Conserving Energy

Energy conservation techniques that can lead to a noticeable decrease in fatigue, weakness, and pain include:

  • Rest periods
  • Stress management and relaxation therapies
  • Maintenance of a healthy weight
  • Use of adaptive equipment (braces, scooters)
  • Avoidance of strenuous exercise or physically demanding activities

However, staying active is still important. Strengthening exercises that do not cause fatigue and excessive stress on joints may be helpful. Simple stretching and strengthening exercises may be recommended. A physical therapist or professional trainer can help design safe and effective ways to stay as active as possible.

Relieving Pain

Physiotherapy (ice applications, heat, and ultrasound) may reduce joint and muscle pain. Acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) help reduce muscle and joint pain. There are also other drugs that doctors are studying.

IV immunoglobulin, a solution of concentrated antibodies, treats the inflammatory mediators present in those with PPS and may be helpful in some people in improving quality of life. However, the evidence is mixed on whether it improves muscle strength and pain.

Breathing and Swallowing

People with breathing and/or swallowing difficulties may find respiratory treatments, diet modification, and instruction in swallowing techniques to be useful.

Diagnosing PPS

It is difficult to diagnose PPS because there are no definitive tests, and the typical PPS symptoms may also be caused by many other diseases, including:

As a result, the diagnosis of PPS is a diagnosis of exclusion, meaning that a doctor can only diagnose PPS by eliminating these other potential causes of the symptoms. In general, a doctor may suspect PPS in a polio survivor if the person is suffering from new muscle weakness, generalized or muscular fatigue, or pain involving the muscles and/or joints, and has experienced at least 15 years of good health, when muscle functions have not deteriorated, since recovering from polio.

Even if these criteria are met, your doctor must still make sure that your symptoms are not caused by other medical conditions. Fibromyalgia, a musculoskeletal disorder that can cause generalized pain and tenderness as well as fatigue, is frequently seen in polio survivors and may sometimes coexist with PPS. If you are found to have another condition that causes PPS-like symptoms, this does not rule out the possibility that you may also have PPS.

If you have had polio, it is important to consider PPS when symptoms develop.


National Institute for Neurological Disorders and Stroke

The Post-Polio Task Force Information Center


Ontario March of Dimes

Post-Polio Awareness and Support Society of British Columbia


Farbu E, Rekand T, et al. Post-polio syndrome patients treated with intravenous immunoglobulin: A double-blinded randomized controlled pilot study. Eur J Neurol. 2007;14(1):60-65.

Gonzalez H, Sunnerhagen KS, et al. Intravenous immunoglobulin for post-polio syndrome: A randomised controlled trial. Lancet Neurol. 2006; 5(6):493-500.

Have you heard about the late effects of polio? Post-Polio Health International website. Available at: Accessed April 12, 2017.

Kaponides G, Gonzalez H, et al. Effect of intravenous immunoglobulin in patients with post-polio syndrome—an uncontrolled pilot study. J Rehabil Med. 2006;38(2):138-140.

NINDS post-polio syndrome page information. National Institute of Neurological Disorders and Stroke website. Available at: Accessed April 12, 2017.

Polio. March of Dimes website. Available at: Updated December 2007. Accessed April 12, 2017.

Poliomyelitis. EBSCO DynaMed Plus website. Available at: Updated January 27, 2017. Accessed April 12, 2017.

Postpolio syndrome. EBSCO DynaMed Plus website. Available at: Updated June 15, 2015. Accessed April 12, 2017.

Ragonese P, Fierro B, et al. Prevalence and risk factors of post-polio syndrome in a cohort of polio survivors. J Neurol Sci. 2005; 236(1-2):31-35.

Last reviewed April 2017 by Michael Woods, MD, FAAP