Other Studied Uses
Acupuncture has been part of the medical mainstream in countries such as China and Japan for centuries. It is also one of the most widely utilized forms of alternative therapy in the United States. More than 10 million acupuncture treatments are administered annually in the US alone. In addition, third-party insurance reimbursement and managed care coverage for acupuncture are increasing.
Due to its popularity, scientific investigation of acupuncture has grown dramatically in recent years, with many new studies reported every week. However, the results have been mixed at best.
What Is Acupuncture?
Simply defined, acupuncture is a treatment method aimed at eliciting a response (such as pain relief) through insertion of very fine needles in the body surface at sites called acupuncture points. A related technique called acupressure (or shiatsu) uses pressure on these points; a related therapy known as electroacupuncture applies electricity to the points.
A wide variety of treatment methods, approaches, techniques, styles, and theoretical frameworks exist within the very broad scope of the term acupuncture. Differences in forms of acupuncture are often cultural; the system of acupuncture practiced in Japan, for example, is quite different from that found in China. Many acupuncturists practice a more or less traditional style called Traditional Chinese Medicine (TCM). Others have adopted modern styles that have little or no reliance on traditional principles.
Acupuncture needles are most often inserted at specific locations on the skin called acupuncture points. These points are located on specific lines outlined by tradition, referred to as meridians or channels. According to Chinese medical theory, there are 14 major meridians that form an invisible network connecting the body surface with the internal organs. Meridians are to conduct Qi, the energy or vital force of the body. Pain or illness is said to result from imbalances or blockages in the flow of Qi through the meridians. Acupuncture is traditionally thought to remove such blockages, restore the normal circulation of Qi, and improve overall health by promoting the balance of energy in the system. However, there is no scientific evidence for the existence of the meridians or Qi itself. (Meridians are not visible under a microscope and, contrary to popular belief, they do not match major nerve pathways.)
In addition to meridians and Qi, the concept of yin and yang is central to acupuncture theory, as it is to all of traditional Chinese philosophy. The terms yin and yang do not represent forces or substances; rather, they are a way to look at the world in terms of the interaction of polar opposites. According to this viewpoint, all movement, growth, and change in the world is a manifestation of the push and pull of these forces. Although seemingly in opposition, these forces are thought to complement and support each other. For example, without rest one cannot exert energy; without becoming tired by exerting energy, it is difficult to sleep. This is just one illustration of the harmony and interaction of yin and yang.
Yang is traditionally associated with heat, power, daylight, summer, and many other active or energetic aspects of life; yin is cold, quiet, and dark. Many illnesses are characterized in terms of an excess or deficiency of either yin or yang, or of both at the same time. For example, when the body is feverish, it is too yang as a whole. There is also a yin and yang balance in each individual organ and part of the body; these can become excessive or deficient, too.
Thus, in TCM, illnesses are described as complex patterns of imbalances and blockages. Treatment is based not on medical diagnosis, but on identifying these problems in the body's energy and seeking to correct them. Does this traditional analysis contain truths about human health or is it just archaic thinking? The answer, as yet, remains unknown.
History of Acupuncture
Primitive acupuncture needles dating back to around 1000 BC have been discovered in archeological finds of the Shan dynasty in China. The theoretical framework underlying the practice of acupuncture was first set forth in the Inner Classic of Medicine or Nei Jing, first published in 206 BC during the Han dynasty.
As an active and growing tradition, the theory and practice of TCM evolved over the centuries, at times undergoing rapid changes. Acupuncture reached perhaps its golden age under the Ming dynasty in the late sixteenth and early seventeenth centuries. Subsequently, it took second place to an ascending practice of herbal medicine. By the time acupuncture came back in vogue in twentieth-century China, it had undergone a major transformation sometimes called the herbalization of acupuncture. Current acupuncture methods given the name Traditional Chinese Medicine are derived to a great extent from this relatively modern revision of the theory. Present-day Japanese acupuncture, however, dates back to earlier versions of acupuncture.
Another major change occurred after the Communist Revolution in 1949. The new leadership, while wanting to carry through a process of modernization, decided to support and preserve traditional medicine. During the Cultural Revolution, the famous "barefoot doctors" were trained in both modern and traditional medicine and sent out to the rural areas to provide medical care for the masses. Today, in the largest and most modern Chinese hospitals, Western medicine and TCM, including acupuncture and herbal treatments, are practiced side by side.
Acupuncture entered France through colonial rule of Vietnam. It was there that, in 1957, the French physician Paul Nogier conceived the notion of auricular (ear) acupuncture. According to his theory, the entire body is “mapped” onto the ear in the form of an inverted fetus. Using this system of correspondence, one can, according to Nogier, treat any part of the body by treating the corresponding part of the ear. This approach was subsequently taken up in China, despite the fact that it had been invented in the West, and had no real foundation in traditional practice. (Classic acupuncture includes only a few points on the ear, and does not refer to any representation of the entire body.) Nogier claimed to have “scientifically tested” his theory, but the methods he used to accomplish this fall far short of anything recognizable as modern science. There are no properly designed studies to support the “little man on the ear” hypothesis, and the one well-designed study on the subject failed to find any correlation between pain in the body and tenderness in corresponding parts of the ear as predicted by Nogier’s theory.262
Acupuncture was virtually unheard of and unavailable in the US until 1972, when President Nixon made his historic visit to China. Among the accompanying press was the well-known journalist James Reston, who was hospitalized while in China and received acupuncture anesthesia. Upon returning to the US, Reston published an article about his experience, stimulating new interest in acupuncture among the public and the medical community. Although it was later discovered that the drugs used along with acupuncture anesthesia probably played a major role, the perception of acupuncture as a powerful treatment caused it to gain respect in the US. Acupuncture schools began to open in the late 1970s and 1980s. With training available in the United States, the number of acupuncturists in this country began to grow rapidly, and today there are many thousands of certified and/or licensed acupuncturists.
How Does Acupuncture Work?
The exact mechanisms by which acupuncture might produce effects on the body remain unknown. Weak preliminary evidence from the 1970s hints that acupuncture encourages the release of endorphins (morphine-like compounds that function as the body's internal pain-regulating substances).1 Support for this theory comes from a study in which use of the drug naloxone, which opposes the effects of endorphins, was found to block pain relief from acupuncture.2 However, the body releases endorphins in response to any sort of pain, and it may be that it is needle-insertion per se, and not acupuncture, that is responsible for the rise in endorphins. Furthermore, there is some evidence that the placebo effect itself works by means of endorphins—in one study, naloxone blocked the ability of a placebo treatment to reduce pain.144
It has also been proposed that acupuncture may influence other chemicals in the body that control various physiologic activities. Preliminary studies have shown possible effects of acupuncture on norepinephrine, acetylcholine, and cyclic AMP, all of which are "chemical messengers" that regulate key systems in the body.4 However, none of this evidence is strong.
What Is the Scientific Evidence for Acupuncture?
Although there have been numerous controlled studies of acupuncture, there is no condition for which acupuncture's supporting evidence is strong.185,227 There are several reasons for this, but one is fundamental: even with the best of intentions, it is difficult to properly ascertain the effectiveness of a hands-on therapy such as acupuncture.
Only one form of study can truly prove that a treatment is effective: the double-blind, placebo-controlled trial. However, it is not easy to fit acupuncture into a study design of this type. One problem is designing a form of placebo acupuncture, and an even more challenging problem is to keep participants and practitioners in the dark regarding who is receiving real acupuncture and who is receiving fake. Without such blinding, the results of the study can be skewed by numerous factors. For a discussion of these factors, see Why Does This Database Rely on Double-blind Studies?
In an attempt to approximate double-blind studies of acupuncture, researchers have resorted to a number of clever techniques. Perhaps the most common involves sham acupuncture. In such studies, a fake version of acupuncture is used to keep participants in the dark. However, because the acupuncturist knows that this is a fake treatment, he or she may subtly convey a lack of confidence in the outcome. Such studies are called single-blind and are not fully trustworthy. (The only exception are studies in which the patient is anesthetized prior to the acupuncture, and is therefore, presumably, incapable of receiving this sort of "top spin.")
To get around this problem and produce a truly double-blind study, some studies may employ technicians trained only to insert needles, rather than real acupuncturists. Such technicians might be given a list of real acupuncture points or phony acupuncture points, without being told which is which. However, it is not reasonable to suppose that an essentially untrained technician can give an acupuncture treatment as effective as that of a real acupuncturist. Furthermore, using a fixed set of points to treat a problem is not true to traditional acupuncture, which always individualizes treatment to the person.
Another approach is to use real acupuncturists to deliver treatment, but to have a separate person evaluate the effects of that treatment. Such studies may be described as partially double-blind (or observer blind); they prevent researchers from biasing their own observations, but they still do not eliminate the problem that the acupuncturist might communicate confidence (or lack of it) to the participants. The placebo effect in acupuncture is very sensitive to expectation; in one study, patients who believed they were getting real acupuncture experienced benefits and those who believed they were getting fake acupuncture failed to experience benefits.186 Whether or not they were actually receiving real or fake acupuncture proved to be irrelevant; it was the belief that mattered. One naturally doubts whether acupuncturists are sufficiently adept at hiding their true feelings from their patients. Osteopathic physician Kerry Kamer suggested a whimsical approach to testing acupuncture: for the placebo group, use actors trained to convey confidence while performing fake acupuncture. However, such studies have not yet been reported.
Despite their limitations, most of the best studies available at present are the single-blind or partially double-blind designs described earlier. Although imperfect, they at least can give us some idea whether true acupuncture might be effective.
There is another problem to consider as well: acupuncture causes a very strong placebo effect, whether it is real or fake. This phenomenon tends to diminish the difference in results between the treatment group and the placebo group and can potentially hide a true benefit by making it too small to reach statistical significance. As an example, consider a study in which 67 people with hip arthritis received either random needle placement or actual acupuncture.118 The results showed improvement in both groups, but to the same extent. Does this mean that traditional acupuncture is actually no better than random acupuncture? Not necessarily. The study could simply have been too small to identify benefits that did occur. In studies that show a strong placebo effect, it may be necessary to enroll hundreds of participants to show benefit above statistical “background noise.” Keep this in mind regarding all of the negative trials described below. A small study can fail to find benefit, but it cannot actually prove lack of benefit.
Some studies have compared acupuncture to other therapies, such as physical therapy or massage. Trials of this kind are good for determining relative cost effectiveness, but they cannot be taken as proof of efficacy for one simple reason: these other therapies have never been proven effective themselves.
Numerous acupuncture studies failed to use placebo treatment or had no control group at all. Such studies prove nothing and generally are not reported here.
There is one additional problem in evaluating the evidence for acupuncture: Many of the studies were performed in China, and there is evidence of systematic bias in the Chinese medical literature.5 In 1998, researchers evaluating the acupuncture studies from China discovered that every one found acupuncture effective. This led them to look further into other Chinese medical research. Review of controlled trials involving other therapies, including standard drugs, showed that Chinese trials reported positive results 99% of the time. Although some bias exists in all medical publications, this finding suggests a particularly high rate of bias in the Chinese research record. A subsequent analysis in 2007 continued to find grossly inadequate standards of rigor in Chinese studies of Chinese medicine.259
Given all the above caveats, the following sections address the science regarding acupuncture. They begin with conditions in which acupuncture research has been mostly positive, continue with those for which the record is mixed, and conclude with those in which the tested form of acupuncture has not proved effective. Note that we also include studies of acupressure and electroacupuncture.
Nausea and Vomiting
Numerous studies have evaluated treatment on a single acupuncture point—P6—traditionally thought to be effective for relief of various forms of nausea and vomiting. This point is located on the inside of the forearm, about 2 inches above the wrist crease. Most studies have investigated the effects of pressure on this point (acupressure) rather than needling. The most common methods involve a wristband with a pearl-sized bead in it situated over P6. The band exerts pressure on the bead while it is worn, and the user can press on the bead for extra stimulation.
Although the research record is mixed, on balance it appears that P6 stimulation offers at least modest benefits for nausea. This approach has been studied in anesthesia-induced nausea and other forms of nausea.
General anesthetics and other medications used for surgery frequently cause nausea. Many controlled studies involving women who have had gynecologic surgery found that P6 stimulation of various types reduced postsurgical nausea compared to placebo.6-11,119,138,145,319 ,345
On the negative side, a double-blind, placebo-controlled study of 410 women undergoing gynecologic surgery failed to find P6 acupressure more effective than fake acupressure (both were more effective than no treatment).139 A small trial of acupuncture in gynecological surgery also failed to find benefit,12 as did three studies of acupressure for women undergoing C-section.146,187-188
Studies of acupuncture or acupressure in other forms of surgery have produced about as many negative results as positive ones.13-20,120,189,292,405
A 2004 review of the entire literature regarding P6 stimulation for postoperative nausea found a total of 26 studies.147 All of these studies suffered from significant flaws; however, on balance the reviewers found that stimulation of P6 does reduce postoperative nausea as compared to placebo. Similarly, a 2008 review of 6 placebo-controlled trials investigating the effectiveness of P6 stimulation on nausea and vomiting both during and after cesarean section found some benefit, though the authors concluded that the results were largely inconsistent.297
In a review of 12 randomized trials with 1,205 patients having a tonsillectomy, perioperative acupuncture was compared to usual care and sham acupuncture. Acupuncture was associated with improvements in nausea, vomiting, and pain postoperatively for up to 48 hours. Patients also used less medications to ease pain. The effect of acupuncture dissipated after 96 hours. Though the results are promising, the data was not evaluated enough to make a firm conclusion.454
One particularly interesting aspect of studies of acupressure for postsurgical nausea is that here a single-blind study is probably as good as a double-blind study. If the acupressure wrist band is not put on till after anesthesia has begun, no amount of confidence or lack of it by the practitioner is likely to alter the placebo effect experienced by the unconscious patient. Thus, studies of acupressure/acupuncture for this condition have a higher potential validity than studies for any of the other conditions listed below. The fact that benefits have been seen strongly suggests that stimulation of P6 does in fact affect nausea. That there is no clear physiological reason why this should be so makes this an intriguing finding, even if the benefit is too slight to make much real difference in postoperative care.
Nausea and Vomiting of Pregnancy
Several controlled studies have evaluated the benefits of acupressure or acupuncture in the nausea and vomiting of pregnancy, commonly called morning sickness. The results for acupressure, though not acupuncture, have generally been positive.229
For example, a double-blind, placebo-controlled study of 97 women found evidence that wristband acupressure may work.21 Participants wore either a real wristband or a phony one that appeared identical. Both real and fake acupressure caused noticeable improvement in more than half of the participants. However, women using the real wristband showed better results in terms of the duration of nausea. Intensity of the nausea symptoms was not significantly different between groups.
However, one large trial of acupuncture instead of acupressure failed to find benefit. This single-blind, placebo-controlled study of 593 pregnant women with morning sickness compared the effects of traditional acupuncture, acupuncture at P6 only, acupuncture at “wrong” points (sham acupuncture), and no treatment.121 As noted earlier, the placebo effect of acupuncture can be very strong. Women in all three treatment groups (including the fake acupuncture group) showed significant improvements in nausea and dry retching compared to the no-treatment group. However, neither form of real acupuncture proved markedly more effective than fake acupuncture. In a review of 8 trials involving over 1,200 pregnant women, there was no reliable evidence that acupressure or acupuncture reduced nausea and vomiting.339 One of these studies involving 230 pregnant women, though, did find that nausea improved over time with the use of electrostimulation, in which a mild electrical current passes to the acupuncture point.
Other Forms of Nausea
A single-blind, placebo-controlled trial of 104 people undergoing high-dose chemotherapy for breast cancer found that electrical stimulation on P6 significantly reduced episodes of vomiting.27 A small study in children receiving chemotherapy for a variety of cancers suggested that acupuncture may reduce the need for antinausea medication.302 Similar improvements were seen in four other studies of acupuncture or acupressure in patients having chemotherapy or radiation .28, 248,258,321 In a small sham-controlled study, acupressure wristbands showed promise, although the benefit seen just missed the conventional cutoff for statistical significance.137 However, equivocal or absent effectiveness were seen in three other studies of wristbands,151,152, 192 and one study failed to find more benefit with real acupuncture than fake acupuncture.153
Several small controlled studies have found acupuncture helpful for tendonitis. For example, a single-blind, placebo-controlled trial of 52 people with rotator cuff (shoulder) tendonitis found evidence that acupuncture is more effective than placebo.29 In another study, 117 people with rotator cuff injury (including tendonitis) were randomized to receive corticosteroid injections plus exercise or 10 acupuncture treatments plus exercise.394 Both groups experienced similar improvements in shoulder function and pain. Finally, in a sizable randomized trial, 425 patients receiving physical therapy for their persistent shoulder pain were divided into two groups: one received single-point acupuncture while the other received a sham treatment (mock transcutaneous electrical nerve stimulation) for three weeks. The acupuncture group showed significant improvement over the control group one week after treatment.276 However, not all studies have been positive. In a small trial of 32 patients with rotator cuff tendonitis, acupuncture was no better than placebo TENS (transcutaneous electrical nerve stimulation) when added to exercise.194
Benefits were also seen in four other studies of people with shoulder or elbow tendonitis.30,31,123,193 In a study of 82 people with elbow tendonitis, deep acupuncture was more effective than shallow acupuncture placebo in the short term, but by 3 months there was no difference between the groups.141 A comparative trial of 20 people found weak evidence that electroacupuncture may be more effective than ordinary acupuncture for elbow tendonitis.129 A 2004 systematic review found a total of five positive controlled studies on acupuncture for tennis elbow and concluded that "strong evidence" supports the use of acupuncture for this condition.154 However, this characterization of the evidence as strong would seem to be premature. For the reasons described in the beginning of this section, virtually all studies of acupuncture are single-blind, and such studies (except when performed on anesthetized patients) cannot exclude the possible effect of confidence conveyed by practitioners performing valid treatment as compared to lack of confidence by those delivering sham treatment. Two other trials failed to find laser acupuncture effective as compared to either sham 142 or other comparable treatments in patients with elbow tendonitis.269 Moreover, 8 sessions of true acupuncture were no better than sham acupuncture in 123 subjects treated for persistent arm pain due to repetitive use.273
As noted above, acupuncture has shown some promise for reducing symptoms of morning sickness. This treatment has additionally been studied for aiding other aspects of pregnancy.
A number of studies, including a 2011 review of 13 trials, found evidence that acupuncture is helpful in reducing labor pain.74,75,156,239,382,387 In a study involving 212 women in active labor, researchers found that, in countries where epidural anesthesia is not available, acupuncture can help to reduce pain compared to standard care early in labor.346
Not all of the evidence supports the use of acupuncture for labor pain, though. For example, in one study, sterile water injections were found to be more effective than acupuncture for lower back pain and relaxation during labor. It is unclear whether or not the patients in the study knew which treatment they were receiving at the time.271 In a placebo-controlled trial and one review of 10 mostly low quality trials, real acupuncture was no better than sham acupuncture in relieving pelvic pain during pregnancy prior to labor.303,334 Along the same lines, a study involving 105 women giving birth to their first baby found no differences in the need for pain relief between real or sham acupuncture.375
A study of 45 pregnant women found that use of acupuncture on the expected birth due date significantly sped up the actual date of delivery.124 However, this trial used a no-treatment control group instead of sham acupuncture. Another study that failed to use sham treatment found minimal evidence that use of acupuncture may help stimulate normal term labor.228 A study of 106 women evaluated whether acupuncture can speed up delivery after prelabor rupture of membranes (“water breaking” too early), and failed to find benefit.263 However, again no adequate control group was used; this is equally a problem for a negative as for a positive study. Finally, in a placebo-controlled trial, real acupuncture administered for 2 days prior to a planned induction of labor (artificial stimulation of labor) was no better than sham acupuncture at preventing the need for induction or shortening the time of labor.308
Acupuncture has also been studied for converting breech presentation of the unborn infant to normal positioning. In a study of 240 women at 33 to 35 weeks gestation, acupuncture combined with moxibustion caused the breech presentation to convert in 54% of women, while only 37% of women in the no-treatment control converted.157 Yet again, placebo acupuncture would have been better than no treatment. Moxibustion was compared to sham acupuncture in a randomized trial of 328 women with fetuses in the breech position during the third trimester of pregnancy. In this study, moxibustion was no more effective than sham acupuncture for correcting breech presentations.429 A much smaller study also found benefits with acupressure.158 In 2008, researchers published a review of 6 randomized controlled trials that investigated acupuncture-like therapies (moxibustion, acupuncture, or electro-acupuncture) applied to a specific point (BL 67). They concluded that these therapies were effective at decreasing the incidence of breech presentations at the time of delivery.284 Again, however, not all of these studies employed a sham acupuncture group for comparison.
According to a small, randomized trial, acupuncture may also help to reduce pain after labor in women undergoing an episiotomy.389
A randomized trial with 120 women in labor compared electro-acupuncture, patient-controlled pain relief via IV, patient-controlled epidural, and no pain relief. All three methods resulted in less pain and C-sections than no pain relief. Electro-acupuncture was no better or worse than the patient-controlled medications.455
Acupuncture has shown inconsistent benefit as a treatment for osteoarthritis.118,126,143,155,195-96,223,243-246,249,257,286,404 While the results of numerous smaller studies suggest that acupuncture is an effective treatment for osteoarthritis (of the knee, in particular), larger studies have generally found it be no more effective than sham (fake) acupuncture.
A 2006 meta-analysis (systematic statistical review) of studies on acupuncture for osteoarthritis found 8 trials that were similar enough to be considered together.245 A total of 2,362 people were enrolled in these studies. The authors of the meta-analysis concluded that acupuncture should be regarded as an effective treatment for osteoarthritis.
However, as it happens, one study comprised almost half of all the people considered in this meta-analysis, and it failed to find real acupuncture more effective than sham acupuncture. In this study, 1,007 people with knee osteoarthritis were given either real acupuncture, fake acupuncture, or standard therapy over six weeks.221 Though both real acupuncture and fake acupuncture were more effective than no acupuncture, there was no significant difference in benefits between the two acupuncture groups. In general, larger studies are more reliable than small ones. For this reason, it is always somewhat questionable when meta-analysis combines one very large negative study and a number of smaller positive ones to come up with a positive outcome.
Another review, published in 2007, nuanced its conclusions differently.255 It concluded that real acupuncture produces distinct benefits in osteoarthritis as compared to no treatment, but that fake acupuncture is very effective for osteoarthritis too. When comparing real acupuncture to fake acupuncture, the difference in outcome—while it might possibly be statistically significant—is so trivial as to make no difference in real life. In other words, virtually all of the benefit of acupuncture for osteoarthritis is a placebo effect.
A similar effect was found in another review of 11 randomized trials. Acupuncture decreased pain in people with osteoarthritis pain compared to those who had sham acupuncture or no treatment. Follow-up ranged from 1-12 months.407
We might add that the apparent slight statistical difference between real and fake acupuncture could easily have been due to problems of single-blind studies, as discussed earlier. To review, acupuncturists who know they are performing real acupuncture may subconsciously convey more confidence to their patients than those who know they are performing fake acupuncture. The history of medical studies makes it clear that such unconscious communications can greatly affect results; since, in fact, the evidence shows only a minute difference between the results of real and fake acupuncture, it is quite possible that this transmission of confidence (or lack of it) is the entire cause of the difference, and that the specific techniques and theories of acupuncture themselves play no role at all.
This may explain why a reliable randomized trial with 252 people found that acupuncture (needle and laser) did not improve knee pain or function when compared to sham acupuncture. When acupuncture was compared to no treatment, it demonstrated statistical improvement, but the clinical effects were minimal for the person being treated.430
A review of 12 randomized trials assessed acupuncture for management of hip pain in 1,763 adults. Acupuncture was compared to sham acupuncture, no treatment, or usual care for a period of 2-12 weeks. Although there were significant improvements in pain and mobility, the level of improvement did not reach a level that would be significant to a patient.440
Acupuncture has shown some promise for various types of headaches, including migraines and tension headaches; however, the research record remains mixed, and the best designed studies have generally failed to find benefit.39-41,42-44,130-134,137,159,199-202,260,265,270,327,392,397,398,456
In a 2008 analysis of 5 randomized controlled trials that were considered highest in quality, researchers determined that real acupuncture has limited benefit over sham acupuncture for tension headache.281 Subsequently, in a large randomized trial involving 3,182 headache patients, the group that received 15 acupuncture sessions over 3 months experienced significantly fewer headache days and less pain compared to the group receiving usual care.288 However, there was no placebo group. A 2011 review of 16 randomized trials involving 1,535 migraine sufferers compared acupuncture with conventional treatment.398 Acupuncture appeared to be more effective than conventional treatment, but there were a number of problems with the studies. For example, there was no consistent definition of conventional treatment or measures of effect.
Another study, though, found more persuasive evidence for migraines.397 In this study, 140 migraine sufferers were randomized to receive acupuncture plus placebo or sham acupuncture plus flunarizine (a medication used to prevent migraines). At 16 weeks, those in the acupuncture and placebo group experienced more migraine-free days than the sham acupuncture and medication group. A drawback of this study is that flunarizine is not a commonly used medication for migraine prevention.
In a review of five randomized trials with 3,962 patients, acupuncture was effective in reducing migraine and tension-type headache pain when compared to patients receiving no acupuncture. However, four randomized trials comparing acupunture to sham acupuncture among 1,414 patients showed mixed results. Two trials found significant pain reduction and two did not.407
In a single blind randomized trial of 480 adults with migraine headaches, 20 sessions of real acupuncture over 4 weeks reduced the number of headache days compared to sham acupuncture 12 weeks after treatment. However, this effect was delayed: there were no significant differences between the groups after 4 weeks after treatment.418
Acupuncture was combined with migraine prophylaxis in a randomized trial of 100 patients who did not have success with standard prophylaxis treatment. Patients continued prophylaxis treatment and were randomized to acupuncture or sham acupuncture for 4 months. There were significant reductions in migraine attacks per month in the acupuncture group, but the effects of the acupuncture treatment declined after 2 months.436
Acupuncture was used as migraine prophylaxis in a review of 22 randomized trials with 4,985 adults. Acupuncture was compared to no acupuncture (no blinding) or sham acupuncture. Overall, acupuncture may help reduce the frequency of migraine headaches when combined with usual care, but it was not very effective in preventing migraines after 3-4 months of treatment.457
A 2006 review of the literature found 10 controlled studies of acupuncture for chronic neck pain.238 The pooled results suggest that acupuncture may be more effective than fake acupuncture, at least in the short term. However, the overall quality of the studies was low. Other randomized trials have found that real acupuncture (versus placebo treatment) improved the quality of life in people with chronic neck pain.377,390
Interestingly, in a study of 177 people with chronic neck pain, fake acupuncture proved more effective than massage! 46 In a pilot study, 10 weeks of acupuncture combined with physical therapy appeared to be more effective than either acupuncture or physical therapy alone for chronic neck pain, at least over the short-term.294
There has been some study of acupuncture for acute neck pain; however, in one of the best of these studies, use of laser acupuncture failed to provide benefit for whiplash injuries.198 In another study, 124 people with chronic or acute whiplash were randomized to receive 12 sessions of real or sham electroacupuncture.381 While those receiving real electroacupunture did have less pain, the results were not clinically significant, and there were no improvements in disability or quality of life.
The evidence regarding acupuncture treatment of dental pain is mixed. A literature review published in 1998 identified four meaningful studies on acupuncture for reducing pain during dental procedures.48 Three of the studies found positive results, but the largest (with 110 participants) found no benefit.49 It was largely on the basis of this review that acupuncture was discussed in the media as a “proven” treatment for dental pain. However, these mixed results hardly constitute proof.
More recent studies have also shown mixed results.50,247 At present, therefore, the available evidence does not provide a reliable basis for concluding that acupuncture is effective for dental pain.
Although some animal studies suggest that ear acupuncture or electroacupuncture may have some benefits for chemical dependency,64,65 study results in humans have been mixed at best, with the largest studies reporting no benefits.
For example, while benefits were seen in a much smaller single-blind trial,67 a single-blind, placebo-controlled trial that evaluated 620 cocaine-dependent adults found acupuncture no more effective than sham acupuncture or relaxation training.117 Similarly, a single-blind, placebo-controlled study enrolling 236 residential clients found no benefit for cocaine addiction from ear acupuncture.66 In a placebo-controlled trial involving 83 people addicted to drugs attending a methadone detoxification clinic, the addition of ear acupuncture did not improve withdrawal symptoms or cravings.310 Adults receiving methadoneand e Methadone, a relatively weak narcotic, is commonly used to treat narcotic addition over the long-term.
The situation is much the same for alcohol addiction. A single-blind, placebo-controlled study of 503 alcoholics failed to find evidence of benefit with 3 weeks of ear acupuncture.125 In addition, a 10-week, single-blind, placebo-controlled study of 72 alcoholics found no difference in drinking patterns or cravings between sham acupuncture and real acupuncture groups.68 There are two other small trials that also failed to find significant benefits.161-162,242 However, one single-blind trial of 54 people did find some evidence of improvement.69
A single-blind, controlled trial of 100 people with heroin addiction evaluated the potential benefits of ear acupuncture.70 However, a high dropout rate makes the results difficult to interpret. Some benefit was found in a small trial with 60 patients taking methadone for heroine addiction. Ear and body electroacupuncture reduced the amount of methodone consumed and helped improve the amount of time it takes to fall asleep when compared to sham acupuncture. Acupuncture did not affect quality of life or heroine cravings.439
In a 1999 meta-analysis of 12 placebo-controlled trials, acupuncture was not found more effective than sham acupuncture for smoking cessation.71 An observer-blind, sham-controlled study of 330 adolescent smokers also found no benefit.72 A 2011 analysis of 12 trials (involving over 2,000 people) found that the people who received real acupuncture had more short-term success in quitting smoking compared to those in the sham group. However, over the long-term, there was no difference between the groups.343 From other studies in the same analysis, researchers also found no evidence that acupuncture was more effective, over the short- or long-term, than nicotine replacement therapy (eg, gum or patch) or psychological interventions.343
A review of 6 randomized controlled trials with 823 patients found acupuncture was over 3 times more effective than sham acupuncture for smoking cessation. The patients were only followed for an average of 6-12 months, highlighting that acupuncture is more successful in the short-term.406
While most addiction studies involve ear acupuncture, a randomized trial compared real versus sham acupuncture on body points. The study found no difference in quit rates, depression, or anxiety.304 One study found that acupuncture may not be effective on its own, but may (in some unknown manner) increase the effectiveness of stop-smoking education. In this sham-controlled study of 141 adults, acupuncture plus education was twice as effective as sham acupuncture plus education and four times as effective as acupuncture alone.59 However, these benefits were only seen in the short term. At long-term follow-ups, the relative advantage of acupuncture disappeared.
Thus far, research has not produced convincing evidence that acupuncture is effective for back pain. Many studies widely cited as providing such evidence were actually invalid due to lack of a proper control group.163-164 There is no doubt that people with back pain given acupuncture report benefits, but the problem is that people given fake acupuncture also experience benefits, often to a similar degree. In a review of 23 randomized trials involving over 6,000 patients with chronic low back, researchers concluded that acupuncture is more effective than no treatment for short-term pain relief, but there was no significant difference between the effects of true and sham acupuncture.307 They also found that acupuncture can be a useful addition to conventional therapies.
A 6-month patient- and observer-blind trial of 1,162 people with back pain compared real acupuncture, fake acupuncture, and conventional therapy.261 Both real and fake acupuncture proved to be twice as effective as conventional therapy according to the measures used. However, there was only a minimal difference between real and fake acupuncture. These results do not, in fact, indicate that acupuncture is effective per se; rather, it shows the significant power of acupuncture as a placebo.
Similarly, in a single-blind, controlled study (using sham acupuncture and no treatment) of 298 people with chronic back pain, use of real acupuncture failed to prove significantly more effective than sham acupuncture.203 Also, in a fairly large randomized trial involving 638 adults with chronic back pain, there was no difference in pain at one year in patients receiving real compared to fake acupuncture (with neither group improving significantly over standard care). Both real and sham acupuncture were, however, associated with improved function at one year. Other studies enrolling a total of over 300 people have also failed to find benefit.28,81-82,204
A trial compared the effects of acupuncture, massage, and education (such as videotapes on back care) in 262 people with chronic back pain over a 10-week period.83 The exact type of acupuncture and massage was left to practitioners, but only 10 visits were permitted. At the 10-week point, evaluations showed benefit with massage but not with acupuncture. One year later, massage and education were nearly equivalent, and both were superior to acupuncture.
One small study found chiropractic spinal manipulation more effective than anti-inflammatory medication or acupuncture for low back pain.165
In another trial, acupressure-style massage was found to be more effective for back pain than Swedish massage.84 However, Swedish massage has not been proven effective for back pain, so this does not prove that acupressure-style massage is effective. Two single-blind, placebo-controlled trials, one with 30 participants and another with 60, also failed to find evidence of benefit.85,86
Two studies did find possible slight benefits with electrical acupuncture for chronic low back pain.166-167 An additional study found acupressure more effective than physical therapy for low back pain,168 and another found some potential benefit with electric acupuncture.
Low level laser therapy (LLLT) is a technique similar to electro-acupuncture that uses precision laser energy instead of electricity conducted through a needle. In a detailed review of 7 randomized trials, researchers were unable to draw any conclusions regarding the effectivenes of LLLT for nonspecific low back pain.278 A randomized trial of 144 adults with chronic nonspecific low back pain found no differences in pain or disability when comparing low- and high-dose laser acupuncture to sham laser over 8 weeks.437
A review of 32 randomized trials compared acupuncture to no or other therapies in patients with nonspecific chronic low back pain, had mixed results. For pain reduction and function, acupuncture was better than sham acupuncture. Acupuncture was more effective for functional improvements when it was used in combination with usual care. Modest improvements in pain and function were seen with acupuncture treatment when compared to pain relievers and muscle relaxants, but the differences were not clinically significant. However, there were a number of issues in the review including types of acupuncture used, duration of treatment, and number of treatment sessions in the patient population that affects the reliability of the results.432
Several other studies have compared acupuncture to other treatments for back pain, such as transcutaneous electrical nerve stimulation (TENS), physical therapy, and chiropractic care, and found them equally effective.87-91 However, because TENS, physical therapy, and chiropractic care have not been proven effective for back pain, studies of this type cannot be taken as evidence that acupuncture is effective. One study did find acupressure massage more effective than standard physical therapy; however, it was performed in a Chinese population that may have had more faith in this traditional approach than in physical therapy.205
Heat sensitive moxibustion was found to be better than acupuncture in managing lumbar disc herniation in a review of 4 low quality randomized trials.424
One small double-blind, placebo-controlled study found real acupuncture more effective than sham acupuncture for menstrual pain.35 (This study used nonacupuncturists given real or fake acupuncture protocols to apply, unbeknownst to them.) In addition, a controlled study of 61 women evaluated the effects of a special garment designed to stimulate acupuncture points related to menstrual pain.76 Unfortunately, in this latter study, researchers chose to compare treatment to no treatment, rather than to sham treatment. For this reason, the results (which were positive) mean little.
A seed-pressure method of auricular acupressure appeared to improve menstrual pain compared to sham auricular acupressure in 74 women.318 The potentially inadequate blinding of participants in this study however, may have limited these results. Similar conclusions were reached in a randomized trial with 113 adolescent and young women.453 Indeed, in a review of 30 controlled trials on menstrual pain, researchers were unable to draw conclusions about the effectiveness of acupuncture and similar treatments for menstrual pain due to widespread study design problems.305 While a review of 27 trials with 2,960 patients concluded that acupuncture might be more effective than medications or herbs for relieving menstrual pain, the studies were of limited quality.329
A review 4 randomized trials compared acupressure and acupuncture to no treatment and sham treatment. The trials evaluated the effects of these interventions on pain reduction in 469 women with dysmenorrhea. Acupressure and acupuncture were associated with greater pain reduction compared to no treatment, but there were no significant differences when compared to sham treatment.425
A more recent systematic review included 42 acupuncture and acupressure trials involving 4,640 women. Acupuncture was associated with pain relief when compared to no or standard treatment, sham acupuncture/accupressure, anti-inflammatory drugs (NSAIDs) and traditional Chinese herbs. Some of the trials showed significant pain relief, while others were more mixed. These results were similar across all comparisons. Despite successes, there is not enough quality evidence to definitively include acupuncture/accupressure as standard treatment. The trials were inconsistent and had several biases that affect outcomes. Researchers found enough weaknesses in the trials to recommend the need for more high-quality studies.452
A randomized trial of 66 women with primary dysmenorrhea showed improvement in pain scores with 16 twice-weekly acupuncture-like transcutaneous electrical nerve stimulation (AL-TENS) compared to sham AL-TENS.414
Acupuncture is widely used in China for treatment of acute stroke. A few controlled studies have been published over the last 10 years, but the best-designed and largest studies failed to find benefit.97,127,169,206-207,279,290,344
For example, a single-blind, placebo-controlled trial of 104 people who had just experienced a stroke failed to find any benefit with 10 weeks of twice-weekly acupuncture.97 Similarly, a single-blind, controlled study of 150 people recovering from stroke compared acupuncture (including electro-acupuncture), high-intensity muscle stimulation, and sham treatment. All participants received 20 treatments over a 10-week period. Neither acupuncture nor muscle stimulation produced any benefits.114 A 10-week study of 106 people, which provided a total of 35 traditional acupuncture sessions, also failed to find benefit.127 Also, 92 patients who received either 12 acupuncture treatments or a comparable sham (fake) treatment demonstrated the same level of improvement up to one year later.279 Finally, a 2011 systematic review, which included 10 randomized trials and 711 patients who had a stroke, failed to find evidence that acupuncture (compared to sham treatment) helped with recovery.344
A few studies did find benefit, but they were very small, and some did not use a placebo group.98-101 One trial of 62 patients found that a 3-week program of transcutaneous electrical stimulation of acupuncture points (beginning about 9 days after stroke) improved muscle tone and strength in the affected leg.316
A large review including 56 mostly poor quality trials reported that acupuncture may benefit post-stroke rehabilitation (based on an analysis of 38 trials),328 and another review of 9 trials found limited evidence in support of moxibustion for stroke rehabilitation.335 Another systematic review focusing on scalp acupuncture did find positive results.401 The review included 7 randomized trials that compared scalp acupuncture to conventional treatment in 230 stroke patients. Those who were in the acupuncture group had fewer neurological problems compared to the patients who had standard care. These kinds of trials however, cannot be blinded (patients know whether or not they have received acupuncture). A review published in 2011 found that scalp acupuncture improved neurologic deficits in 7 randomized trials of 458 stroke patients when compared to usual care. Patients were assessed on consciousness, gaze, facial weakness, language, walking ability, and motor function.416
A randomized trial of 120 post-stroke patients with hemiplegia and stage I shoulder-hand syndrome compared electric acupuncture and massage to rehabilitation therapy for 6 weeks. Patients having electronic acupuncture and massage had significant improvement in pain with passive movement, and functional ability. Patients with electric acupuncture were also less likely to progress to the next stages of shoulder-hand syndrome at 3 months.420
A review of 8 randomized trials showed there was insufficient evidence for acupuncture to reduce chronic nerve pain following a stroke. The trials compared acupuncture to anticonvulsants, pain relievers, and transcranial magnetic therapy.446
A review of 21 randomized trials with 1,421 adults found that acupuncture, in addition to medications and rehabilitation, was associated with improvements in cognitive function. However, there was no placebo or comparative treatment.447
A larger review of 31 randomized trials, which may include some of the trials summarized above, found some positive effects for acupuncture on people who were recovering from a stroke. The 2,257 patients were in different stages of their recovery. Acupuncture was compared to placebo, sham acupuncture, or no acupuncture. Consistent positive effects were seen in motor function, cognitive function, depression, swallowing problems, and pain. However, the trials lacked quality measures including, adequate size, structure, comparative treatment, and blinding. The lack of quality measures influence the outcomes of the trials making it difficult to make solid conclusions about the effects of acupuncture on stroke recovery.459
Acupuncture has been explored as a means of reducing pain after surgery with encouraging but not unequivocal results. A double-blind, placebo-controlled study of 42 people undergoing arthroscopic knee surgery found that the use of acupuncture during surgery did not reduce pain levels during the subsequent 24 hours.54 Another double-blind, placebo-controlled trial of 50 women undergoing hysterectomy found no benefit with electroacupuncture,55 and a double-blind study of 71 people undergoing abdominal surgery failed to find acupressure helpful.60
However, some benefits of acupressure were reported in a single-blind trial of 40 patients undergoing arthroscopic knee surgery.56 A small randomized trial involving 22 patients found that preoperative electroacupuncture, compared to sham transcutaneous electrical nerve stimulation (TENS), reduced pain and the need for pain medication after cardiac surgery.384 In addition, a special form of needle insertion called intradermal acupuncture reduced postsurgical pain in 107 people undergoing abdominal surgery.38 Ear acupuncture has also shown promise.215,237,375 For example, in an analysis of 5 trials, patients who received ear acupuncture (auricotherapy) did not use pain medication as much as those in the control groups (sham auriculotheapy, placebo, or usual care).376 Additionally, in a 2008 review of 15 randomized controlled trial, researchers determined that acupuncture (of the ear and other acupuncture points) is capable of reducing pain and the need for opioid medications (morphine and related agents) immediately following surgery compared with sham acupuncture.283
In a randomized trial of 80 patients having total knee arthroplasty, acupuncture was associated with greater reduction in pain and swelling, and quicker return to preoperative range of motion compared to range of motion exercises alone.422
Electric accupuncture was associated with significantly improved time to defectation in 165 patients with colorectal cancer who had laparoscopic surgery. Electric acupuncture was compared to sham electric acupuncture and no acupuncture. Electroaccupuncture was also associated with reduced pain, less pain medication, and improved time to walking.423
Acupuncture has also been studied as a potential treatment for other surgery-related problems. For example, gastroparesis is a common complication of abdominal surgery. With this condition, the stomach is unable to properly empty its contents after eating. In a controlled trial, 63 people who underwent abdominal surgery were randomized to receive acupuncture or a standard medication used to treat gastroparesis (metoclopramide given intravenously 3 times a day).402 According to the researchers, those in the acupuncture group experienced a higher cure rate.
In pediatric patients undergoing a needle biopsy of the kidney, laser acupuncture significantly lowered heart and breathing rates during the biopsy, and reduced pain afterwards in a randomized trial with 81 people (ages ranged from 7-26 years old). Laser acupuncture was compared to sham acupuncture, which was given before biopsy.462
Other Studied Uses
Bee venom acupuncture (BVA), which involves the injection of diluted bee venom directly into acupoints, has been used for the treatment of pain. A recent analysis of four well-designed, randomized trials, comparing bee venom plus classic acupuncture against saline injection plus classic acupuncture, found that the BVA-classic acupuncture combination was significantly more effective for musculoskeletal pain.272
Acupressure and acupuncture have been tried for insomnia with mixed results. A single-blind, placebo-controlled study involving 84 nursing home residents found that real acupressure was superior to sham acupressure for improving sleep quality.32 Treated participants fell asleep faster and slept more soundly. In a similar study, researchers found that performing acupressure on a single point on both wrists for five weeks improved sleep quality among residents of long-term care facilities compared to lightly touching the same point. .337 Another single-blind, controlled study reported benefits with acupuncture, but failed to include a proper statistical analysis of the results.33 For this reason, no conclusions can be drawn from the report. In another trial, 98 people with severe kidney disease were divided into three groups: no extra treatment, 12 sessions of fake acupressure (not using actual acupuncture points), and 12 sessions of real acupressure.5 Participants receiving real acupressure experienced significantly improved sleep as compared to those receiving no extra treatment. However, fake acupressure was just as effective as real acupressure. In a fourth randomized trial involving 28 women, six weeks of auricular (outer ear) acupuncture was more effective than sham acupuncture.280 In one study, magnetic pearls used to stimulate acupuncture points in the ear seemed to show some benefit as compared to nonmagnetic stimulation of ear points.170 A small, single-blind, placebo-controlled study of 60 adults with primary insomnia found that 3 weeks of electroacupuncture improved sleep efficiency and decreased wake time after sleep onset.320
Acupuncture and acupressure showed some promising results in a review of 33 randomized trials with 2,293 patients ranging in age from 15-98. Needle acupuncture improved sleep quality in 13 trials consisting of 965 patients. However, only two of these trials compared acupuncture to sham acupuncture. In the other 11 trials, needle acupuncture was added to medications or Chinese herbs. Electroacupuncture, acupressure and magnetic acupuncture also showed benefit, but studies were small and limited by methodological shortcomings.411
Depression can affects sleep patterns. Many people experience insomnia, even with treatment. Treatments included acupuncture, minimal acupuncture, or sham acupuncture. The 150 patients received acupuncture over a 3-week period. Though acupuncture was well-tolerated, there were not many differences between the groups.451
Chronic Fatigue Syndrome
Although anesthesia apparently performed entirely with acupuncture first raised Western interest in acupuncture, the original demonstrations of acupuncture anesthesia have been discredited. It now appears that if acupuncture has any anesthetic effect at all, it is extremely modest.214 At most, acupuncture may be capable of slightly decreasing the required dose of general anesthetic necessary to induce anesthesia (but even this has not been consistently seen in studies).171-173,214,256
A 6-month, single-blind, controlled study of 67 women with frequent bladder infections found that acupuncture therapy reduced the frequency of infection.34 Another study found that acupuncture may be helpful for hyperactive bladder (frequent need to urinate without the presence of an infection).208
A study of 52 people with allergic rhinitis (hay fever) found that acupuncture plus Traditional Chinese herbal treatment was slightly more effective than fake acupuncture plus fake Chinese herbal treatment.175
However, acupuncture alone has mixed results for treatment success.176 A review of 7 placebo-controlled trials failed to find convincing evidence for acupuncture’s effectiveness against allergic rhinitis.277 While a randomized trial with 175 adults found acupuncture was associated with significant improvement in symptom severity when compared to sham acupuncture. Participants used the treatment for 4 weeks.443
A Chinese study found that acupuncture plus moxibustion was more effective for Bell's palsy than drug treatment.177 However, in a review of 6 studies involving 537 Bell's palsy sufferers, researchers could draw no conclusions about the beneficial effects of acupuncture due to poor study quality.338. In another review of 10 randomized trials of 975 patients, acupuncture alone or with drug therapy was associated with symptom improvement compared to drug therapy alone. For the same reasons as the previous review, it is not clear if acupuncture is an effective treatment.421
The evidence has been mixed regarding whether acupuncture is beneficial for menopause. Five small controlled studies reported that acupuncture can improve menopausal symptoms. But, most of these studies suffered from significant problems in design or statistical analysis.128,178,226, 234,251
Two trials failed to find acupuncture beneficial for hot flashes.234,282 However, a trial of 175 perimenopausal and postmenopausal women concluded that adding acupuncture to usual care reduced hot flash frequency compared to usual care alone in the first four weeks after treatment.330 A large randomized trial involving 267 post-menopausal women found that the addition of acupuncture to self-care advice significantly reduced the frequency and intensity of hot flashes in the first 12 weeks.331,336 However, the benefits were lost 6 months later. In another, similar trial, 81 women were randomized to receive either 12 months of real acupuncture followed by 6 months of sham acupuncture or 6 months of sham followed by 12 months of real acupuncture.386 After 6 months, the women in the treatment group reported fewer hot flashes compare to those in the sham group. This affect did not last, though. After 12 months, both groups reported a similar frequency of hot flashes.
A review of 6 trials did not find promising results.315 True acupuncture was no more effective than sham acupuncture for menopause.449 One small study found no benefit for the psychological distress associated with menopause.179
Results were similar in a small single-blind randomized trial of 54 women. Acupuncture was compared to sham acupuncture for hot flashes in peri-menopausal and post-menopausal women. There was no difference between the groups in a combined measure of hot flash frequency and severity 8 weeks after treatment ended.410
Acupuncture in combination with dietary principals used in the Traditional Chinese herbal medicine and self-massage was significanlty better than diet and self-massage alone in a randomized trial with 100 menopausal women. The addition of acupuncture was associated with a decrease in the frequency of hot flashes, sudden sweating, sleep disorders, irritability, and headache. Acupuntcure was also associated with decreased intensity of memory loss, vaginal dryness, skin changes, urinary tract problems, and genital itching.444
A review of 31 randomized trials with a total of 2,433 peri- and postmenopausal women found signficant reduction in sleep disturbances when using acupuncture. Though the results showed some successes with treatments, all trials used different control treatments and acupuncture therapies.450
Another small placebo-controlled study in breast cancer patients suffering from hot flashes due to their treatments suggested some benefit for acupuncture, though the results were inconclusive for similar reasons.299 However, another study did not find acupuncture effective in these patients,267 and a 2008 review of all existing studies on the subject concluded that the evidence does not support a beneficial effect for acupuncture in breast cancer patients suffering from hot flashes.306
Acupuncture has been studied for use in cancer treatment support. In a small randomized trial of 43 breast cancer patients, 6 weeks of acupuncture twice-weekly reduced joint pain attributed to aromatase-inhibitor therapy.325 Another small randomized trial of 70 patients found that acupuncture may decrease dry mouth and pain after neck dissection for cancer treatment.332 Electroacupuncture relieved pain severity better than no treatment in a randomized trial of 67 postmenopausal women with aromatase-inhibitor therapy-related joint pain. However, there were no significant differences in pain severity when electroacupuncture was compared to sham acupuncture.442
A systematic review of 3 randomized trials involving 123 people with head and neck cancer found that real acupuncture was more effective than sham acupuncture in reducing the risk of dry mouth (xerostomia) due to radiation therapy.379 A subsequent study also supports the use of acupuncture in reducing dry mouth in such patients. But, unlike the previous trial, this one compared acupuncture to standard care (rather than to sham treatment).391
Many cancer patients suffer unrelenting pain, which is often challenging to effectively treat while maintaining an acceptable quality of life. Researchers reviewed 3 small, randomized trials involving 204 patients on the effectiveness of acupuncture for cancer-related pain.340 The authors concluded that there was insufficient evidence to say whether or not that acupuncture is helpful in relieving this type of pain. More high-quality studies are needed.
People with cancer often experience fatigue. Acupuncture has shown a bit of promise for improving this symptom.266
A 2006 review of acupuncture for treatment of fibromyalgia found five controlled studies, none of which were of high quality.235 The autors of another review of 7 trials were unable to determine the effectiveness of acupuncture for fibromylgia due to the unreliability of the studiies.324 Overall, the results do not provide reliable evidence that acupuncture is helpful.
Acupuncture added to standard medications was associated with symptom improvement in a randomized trial of 164 patients with fibromyalgia. Improvements were noted in pain intensity, pain threshold, quality of life, and physical functioning when compared to sham acupuncture. Treatment lasted for 9 weeks, but the effects of the acupuncture lasted through the 1-year follow-up period.460
Evidence for acupuncture’s effectiveness for depression has been mixed. In a study of 151 depressed patients, twelve sessions of acupuncture failed to prove more effective than fake acupuncture.236 However, another sham-acupuncture controlled trial evaluated 43 people with depression and 13 people with generalized anxiety disorder.80 The results suggest that 10 (but not 5) acupuncture sessions can significantly improve symptoms. One study of 80 patients with major depressive disorder found that adding acupuncture to a lower dose of antidepressant (fluoxetine) improved anxiety and had a similar overall therapeutic effect as sham acupuncture with a higher dose of antidepressant.322 In a mathmatical review of the results of 8 randomized trials, the impact of acupuncture on depression was unconvincing.285 However, in another review of 20 trials involving 2,000 patients with major depression, real acupunture's effectiveness was comparable to that of antidepressants, but was no more effective than sham acupuncture for this population.336
A review of 30 randomized trials found that acupuncture in combination with regular dose drug treatments may improve mental state, reduce insomnia, and decrease the number of hospital stays in people with schizophrenia. The trials compared different forms of acupuncture plus antipyshcotic medication to antipsychotic medication alone.433
A 2010 review of 9 mostly poor quality trials determined that there is currently insufficient evidence to conclude that acupuncture is effective for premenstrual syndrome.333
In vitro fertilization
Although open trials appeared to show benefit,211-212 at least 3 controlled studies failed to find acupuncture helpful for improving the success rate of in vitrofertilization (IVF).213,274,314 A 2008 analysis of 7 randomized trials found that, on balance, acupuncture may significantly improve the odds of pregnancy in patients undergoing IVF. However, since not all of these studies used sham (fake) acupuncture as a control, the reliability of this conclusion is questionable.275 Moreover, a second analysis in the same year of 13 randomized controls trials investigating the effectiveness of acupuncture in 2,500 women undergoing a specialized IVF procedure, in which sperm is injected directly into the egg, found no evidence of any benefit.289 But the story does not end here. In a subsequent review of 13 trials, a different group of researchers concluded that acupuncture may improve the success rate of IVF, but only if it is used on the day of embryo transfer (when the fertilized egg is placed into the womb).300 According to this study, acupuncture is not effective when used up to 3 days after embryo transfer or when eggs are being retrieved from the ovaries. Electrical stimulation of acupuncture points was the focus of a randomized trial involving 68 women. There were significant improvements in the rate of successful implantations, and pregnancy and live birth rates compared to sham electrical stimulation. The successes are thought to be related to a protein that is released during electrostimulation. The protein appears to improves blood flow in the uterine lining.448
Acupuncture may be more effective than sham acupuncture and as effective as standard treatments for temporomandibular joint (TMJ) pain.52, 233, 326 One study of 110 people with pain found acupuncture at least as effective as standard occlusal splint therapy.53 Another small study involving 40 patients with TMJ pain, however, found no difference between placebo and low-level laser therapy (LLLT) directed at painful points; both groups benefited equally.296 However, in a double-blind, randomized trial comparing real LLLT with sham LLLT, the real therapy was more effective for TMJ pain after 8 sessions.311 Instead of needles, low-level laser therapy involves the use of laser energy directed on or off acupuncture points.
A single-blind trial tested acupuncture on a group of 36 healthy young men and found some evidence of improvement in sports performance.95 However, a single-blind, controlled study of 48 people found that use of acupuncture did not reduce muscle soreness caused by exercise.105
One study purportedly found that acupressure reduced fatigue in people with severe kidney disease.181 In fact, it found that both sham acupuncture and real acupuncture reduced fatigue as compared to no treatment, but that real acupuncture was not more effective than fake acupuncture.
Manual acupressure and electroacupuncture were associated with improvements in depressive symptoms, fatigue, and sleep quality in patients with moderate to severe kidney disease. The review included 24 randomized or quasi-randomized trials with 1,787 patients, who were also undergoing dialysis. The evaluated trials were unblinded, meaning people were aware of their treatment. This bias can affect the results of the trials, making it appear the treatment is more effective than it really is.458
One study found minimal benefits for Parkinson’s disease.182 Another study failed to find any benefits.217 In two comprehensive reviews of multiple clinical trials, independent sets of researchers concluded that there was currently no well established evidence for acupuncture’s effectiveness in this condition.287,291
Vocal Cord Dysfunction
A Chinese study reported that acupuncture is helpful for vocal cord dysfunction.220
A study that reported acupuncture's benefits for chronic prostatitis failed to use a control group and is, therefore, meaningless.241 However, another study found that real acupuncture was more effective than sham acupuncture at reducing the symptoms of chronic prostatitis both during treatment and for a 6-month period following treatment.268 Another study suggested that electroacupuncture may improve symptoms in men with chronic prostatitis (or a related condition called chronic pelvic pain syndrome), but this study was very small.317 In a randomized trial with 54 men, 7 weeks of acupuncture was associated with pain and symptom improvement compared to standard treatment of a 6-week course of an antibiotic and pain reliever.445
After an acute attack of shingles, pain may linger for months or years, causing what is known as post-herpetic neuralgia. A single-blind, placebo-controlled study of 62 people with pain of this type failed to find any benefit with acupuncture.94
Two separate groups of researchers conducting detailed reviews of 8 randomized controlled trials found some beneficial effects of acupuncture for rheumatoid arthritis, but were unconvinced that it was more beneficial than sham acupuncture or other standard treatments.293,295
Another review of 11 randomized trials did not find that mediation, progressive muscle relaxation, static magnetic therapy, acupuncture or tai chi relieved pain in patients with rheumatoid arthritis. The 11 trials included a total of 607 patients.415
Carpal Tunnel Syndrome
Acupuncture has also been studied as a treatment for carpal tunnel syndrome, a common nerve disorder affecting the wrist and hand. Over a 4-week period, 77 people with mild to moderate carpal tunnel syndrome were randomized to receive medication (prednisolone) or 8 sessions of acupuncture.380 During the 7-month and 13-month follow-ups, those in the acupuncture group reported a greater improvement in their symptoms compared to the medication group.342 In addition, researchers analyzed 6 low-quality, randomized trials investigating acupuncture (and similar therapies) for CTS. In two of those trials (144 subjects), acupuncture was slightly better at improving symptoms than cortisone (steroid) injections, a standard treatment for CTS.347
There have been numerous reports about acupuncture treatment for asthma,57,61 but most published studies are of low quality, with results being contradictory at best.62,63,183 One study failed to find acupuncture helpful for shortness of breath associated with advanced cancer.218
Addition of acupuncture to regular therapy was found to have short term benefits in a randomized trial with 122 children (up to age 6). There was a reduction in asthma symptoms and use of inhaled steroids at 3 months, but not at the 1-year follow-up visit. The trial also had a high dropout rate (60% completed treatment through 3 months and 43% were evaluated at 1 year).426
Moxibustion (a specialized form of acupunture that uses heat) was found to have similar effects on asthma symptoms as seretide (an inhaler with salmeterol and fluticasone) in adults with chronic, moderate, persistent asthma. In a randomized trial with 288 adults, moxibustion treatment (50 sessions for 3 months) was associated with improvement in lung function and reduced attack frequency per week. Moxibustion was also associated with reduced attack frequency at a follow-up visit of 6 months.427 Moxibustion also had similar benefits as seretide for asthma symptoms and pulmonary function in a review of 14 randomized trials with 637 patients over 15 years old. Moxibustion was used for 3 months, with follow-up for 6 months.441
Chronic Obstructive Pulmonary Disease
Researchers have studied the potential benefits of acupuncture in people with chronic obstructive pulmonary disease (COPD). Sixty-eight adults were randomized to receive real or sham acupuncture once a week for 12 weeks.403 Those who received the real treatment experienced less shortness of breath after an exercise test compared to the control group.
Peripheral neuropathy (nerve pain in the extremities) is a common complaint in HIV infection. A placebo-controlled trial of 239 people with HIV found acupuncture no more effective than placebo in peripheral neuropathy.92 Interestingly, the study also tested drug therapy for peripheral neuropathy and found it ineffective, as well.
Gastrointestinal (GI) problems, like diarrhea and nausea, are common side effects for people with HIV who are receiving highly active antiretroviral therapy (HAART). One hundred and thirty HIV patients on HAART were randomized to receive 1 of 4 treatments: acupuncture plus relaxation therapy, acupuncture plus health education, sham acupuncture plus relaxation therapy, or sham acupuncture plus health education. After 4 weeks of treatment, the people in the acupuncture plus relaxation group experienced a greater improvement in their GI symptoms compared to the other groups.
High Blood Pressure
A substantial study (192 participants) failed to find acupuncture more helpful than fake acupuncture for high blood pressure.230 However, another study, this one enrolling 160 people, did report benefit.252 A much smaller study also reported benefits,250 but there were problems in its statistical analysis. In a review of 11 randomized controlled trials on the subject, researchers determined that acupuncture’s ability to lower blood pressure remains inconclusive.309
Acupuncture is probably not effective for epilepsy. A single-blind, controlled trial of individualized acupuncture for 34 people with severe epilepsy found no benefit,96 and subsequently, a comprehensive review of 11 studies found no reliable evidence of its effectiveness.301
Acupuncture showed promise of reducing seizure frequency in some people with epilepsy in a review of 17 randomized trials with 1,538 people. The trials compared acupuncture (alone or with medication) to placebo or sham acupuncture; or medications or no treatment. Although some had a lower frequency rate of seizures with acupuncture alone or with medications, the quality of the trials was low, reducing the reliability of results. Current evidence does not support the use of acupuncture as treatment for epilepsy.434
One controlled study failed to find electroacupuncture effective for reducing discomfort during colonoscopy.25
Spinal Cord Injuries
A controlled study purportedly found acupuncture helpful for speeding recover in people with spinal cord injuries, but it failed to use a sham-acupuncture control group.22
Acupuncture was not effective as treatment for tinnitus symptoms in a review of 13 low-quality randomized trials with 616 patients. Only one of two open trials showed long-term improvement.413
Irritable Bowel Syndrome
A number of studies, including systematic reviews, have not found strong evidence to support the use of acupuncture for the treatment of irritable bowel syndrome (IBS).51,115,219,313,399,400 The most recent review included 17 trials involving 1,806 people and compared real acupuncture to a range of control groups, such as sham acupunture, psychotherapy, medication, among others.400 In the 5 trials that included real versus sham acupuncture, there were no significant differences between the two treatment groups on IBS symptoms. Other trials with a placebo control showed a positive effect, though. For example, people receiving acupuncture treatments reported more symptom relief compared to those receiving psychotherapy or medication.
Moxibustion, the use of heat to stimulate acupuncture points, was associated with improved IBS symptoms. The review included 11 low-quality randomized trials comparing moxibustion alone or moxibustion with acupuncture to drug therapy alone. However, the low quality of the trials can affect the reliability of outcomes. Researchers in all acupuncture trials listed above highlighted the need for more studies.435
In a placebo-controlled trial, 60 nursing women received needle acupuncture, 56 women received laser acupuncture, and 60 women received placebo acupuncture.104 The results showed no differences in milk production. In a subsequent trial, 90 women were randomized to receive acupuncture (twice weekly for 3 weeks) or observation.388 Those in the acupuncture group were better able to maintain breast-feeding for the first 3 months compared to the control group. The lack of a placebo control in the latter trial, however, means the two studies are not comparable.
In a small trial, 33 people with glaucoma (a condition characterized by abnormally elevated pressure inside the eye) were randomized to receive real auricular acupressure (with massage) or sham acupressure (without massage).383 At weeks 3 and 4, subjects in the acupressure group did have an initial improvement in their intraoccular pressure. At weeks 2-4, their visual acuity also improved. However, the results did not last long, and there were no significant differences between the two groups.
Autistic Spectrum Disorder
A review of 10 trials focused on the use of acupuncture as a potential treatment for autistic spectrum disorder.385 Three hundred and ninety children and teens (aged 3-18 years old) with autism received treatment from 4 weeks to 9 months. Some of the trials compared real acupuncture to a sham version, while other trials compared acupuncture and traditional treatment plus traditional treatment alone. The authors concluded that there was not enough evidence to support the use of acupuncture to improve the core symptoms of autism (eg, impaired social interactions or thought processes).
Preliminary evidence suggests that acupuncture may help prevent abnormal heart rhythms in people with atrial fibrillation who have undergone cardioversion (an electrical shock is delivered to the heart to return it to a normal rhythm).393
A randomized trial of 80 women with post-hysterectomy urinary retention showed improvement in bladder function with acupuncture compared to acupoint injection of vitamin B12. Each group had daily treatment over the course of five consecutive days. Improvement was seen in 90% of the acupuncture group after two treatment courses compared to 72.5% in injection group.408
Urinary Stress Incontinence
Stress incontinence is leakage of small amounts of urine when pressure increases in the bladder. This can occur during exercise, laughing, sneezing, or coughing. Stress incontinence is caused by weakening muscles that support the bladder. In a randomized trial of 504 women, electroacupuncture was associated with a significant reduction in urine leakage when compared to sham acupuncture. Treatments were applied to the lower back for 6 weeks. Electroacupuncture also improved the number of incontinence episodes and quality of life at the end of the treatment period. Results were less consistent at the 30-week follow-up.463
Epigastric Discomfort and Ulcer
Functional dyspepsia includes a wide range of symptoms that cause epigastric pain or discomfort. A randomized trial of 72 patients suffering from functional dyspepsia show significant symptom relief with real as opposed to sham acupuncture. Those who had real acupuncture experienced less bloating and early saiety, though the differences were minor and may not have been clinically meaningful.409
Similar results were found in a review of 7 trials with 542 patients. Acupuncture or electroacupuncture were compared to sham acupunture or medications. Significant symptom relief was found in those who had acupuncture for 4 weeks. Acupuncture was also associated with improved quality of life, and decreased anxiety and depression. All trials had some biases, which may make it more difficult to interpret results.431
Trigeminal neuralgia is a condition that involves recurrent short episodes of severe, sudden pain along one or more branches of the trigeminal nerve. It is usually confined to one side of the face ranging from the forehead to the lower jaw. In a randomized trial of 65 patients with trigeminal neuralgia, electroacupuncture with deep needling to reach the sphenopalatine ganglion (adjacent to the trigeminal nerve itself) reduced frequency and intensity of pain compared to superficial needling. Clinical cure was achieved in 28% of patients with deep needling compared to 13% with superficial needling.412
Post-traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a type of anxiety disorder. It can occur after extreme emotional trauma that involved the threat of injury or death. In a systematic review of 4 randomized and 2 uncontrolled trials, acupuncture, alone or in combination with cognitive behavioral therapy (CBT), was associated with an improvement in PTSD symptoms in 646 patients. Acupuncture was as effective as CBT or selective serotonin reuptake inhibitors (SSRIs), and when combined with moxibostion, appeared to be more effective than SSRIs.417
Persistent hiccups are defined as those lasting more than 48 hours and intractable hiccups last for more than one month. Acupuncture options for hiccups were evaluated in a review of 4 poor-quality trials of 305 patients. Two trials in the review were randomized. One trial of 80 patients found that acupuncture with an injection of frog extract yielded significant improvements in hiccups when compared to acupuncture with an injection of vitamin B6. Hiccup cure rates were similar at 1 month in a second trial of 60 patients when comparing sham acupuncture to real acupuncture.
The other two trials compared acupressure points and time. One quasi-randomized trial found that using 4 acupuncture sites was associated with significantly greater improvement in hiccups compared to using 3 acupuncture sites in one trial of 80 patients. Another quasi-randomized trial of 85 patients found that acupuncture with body acupoints for 1 hour and scalp acupoints for more than 6 hours had a significantly greater improvement in hiccups compared to acupuncture with needles placed in the same body and scalp acupoints for 30 minutes.419
Minor injuries include trauma to a joint, ligament, tendon, or muscle that is the result of an accident or sports. They also may include cuts and bruises. In general, minor injuries can be treated with home care and medications. Acupuncture was evaluated in a review of 20 randomized or quasi-randomized trials with 2,012 people who had a sprained ankle. Acupuncture was associated with an improved cure rate or function when compared to no treatment, other nonsurgical treatments, or in combination with other nonsurgical treatments such as topical gels, far-infrared lamp radiation, electrophysical therapy, and Chinese herbal medications. However, there was no differences in cure rate between acupuncture and Chinese herbal patches, ice packs, or elastic bandage and immobilization. The evaluated trials were unblinded, meaning people were aware of their treatment. This bias can affect the results of the trials, making it appear the treatment is more effective than it really is.428
Some success was reported with self-acupuncture applied to the perineal area, the area between the anus and base of the genitals. Applied pressure and massage to this area was associated with improved bowel function and quality of life when compared to standard treatment alone in a randomized trial of 100 adults with functional constipation. The trial was unblinded and the patients self-reported their results, which may have affected outcomes.438
Electroacupuncture was associated with improved bowel function when compared to sham electroacupuncture in a randomized trial with 1,075 patients. Bowel function included frequency, completeness, and spontaneity of bowel movements. The participants had 28 electroacupuncture sessions over the course of 8 weeks.461
What to Expect During an Acupuncture Treatment
Acupuncture therapy has its own style and atmosphere, both like and unlike an ordinary medical encounter. Your first session will begin with a thorough analysis of your condition and health history. If the acupuncturist practices according to the principles of TCM, you will be asked a number of questions about your specific complaint and your general health, including how well you sleep, digest your food, eliminate, and breathe, your energy level, and so forth. All of these factors are considered relevant. The acupuncturist may ask questions that seem to have little bearing on your condition, such as, "Do you tend to feel cold or hot most of the time?" TCM looks for overall patterns in both physical and emotional well-being, which guide the acupuncturist in developing a treatment plan that is specific not only for your symptoms, but for your overall health pattern.
Depending on your specific complaint and your individual symptom pattern, the acupuncturist may use only a few needles or as many as 20 or more. Acupuncture needle sizes are typically 32- to 36-gauge, which means they are about ¼ mm in diameter, much smaller than a hypodermic needle. Unlike hollow hypodermic needles, acupuncture needles are solid, which allows them to penetrate the skin easily and relatively painlessly. Acupuncture needles may produce a mild pricking sensation when inserted, but sometimes you will feel nothing at all as the needle is inserted. The needles are generally inserted to a depth ranging from a few millimeters to ½ inch or so. Insertion depth is deeper at the more fleshy areas of the body, such as the thighs and buttocks.
Acupuncture needles are typically inserted through a plastic tube that guides the needle into the skin. This is a fairly modern needle insertion technique. Traditional freehand insertion is also used; most acupuncturists are trained in this method. Virtually all acupuncturists in the United States now use pre-sterilized, one-time-use disposable needles, which eliminate any risk of cross-infection.
The acupuncturist may twirl the inserted needles and ask you to say when you feel a mild achy, heavy sensation; or the area may feel slightly numb or tingly. These sensations, described in TCM as the arrival of Qi, are regarded as a positive response that will enhance the effectiveness of the treatment.
Whatever you feel, the sensation should be mild, not overly unpleasant, and should subside within a few minutes. If any needles are genuinely painful, inform the practitioner so he or she can adjust the depth or remove the needle altogether. The needles are generally left in place for 20 to 30 minutes. During this time, you should feel comfortable and relaxed, and you may fall asleep.
Acupuncturists may also employ a technique known as electroacupuncture, in which electrodes are attached to the needles and a mild current is applied. This is intended to increase the stimulation of the needle and is generally used for more painful conditions. Electroacupuncture produces a tingly, pulsating sensation. The acupuncturist can control the intensity and adjust it to a level that is comfortable for you.
Traditionally trained acupuncturists often use heat as well as needles to stimulate acupuncture points with a procedure called moxibustion, which involves a mixture of herbs rolled into a cigar-like shape. The roll is lit, and the burning end is held over the skin, allowing the heat to penetrate the area around the acupressure point. The moxa roll never touches the skin, so you will not be burned. The acupuncturist will ask you to let him or her know before it gets too hot. Moxibustion is generally quite pleasant. It is regarded as a "tonifying" treatment, which means it is intended to strengthen function.
How to Choose a Qualified Acupuncturist
Acupuncture is a licensed health profession in 39 states and the District of Columbia. Most states require at least 3 years of training at an accredited school of acupuncture and passage of a national board certification exam administered by the National Certification Commission for Acupuncture and Oriental Medicine (NCCAOM). Most states grant the title Licensed Acupuncturist, Certified Acupuncturist, Registered Acupuncturist, or simply Acupuncturist. A few states allow acupuncturists who have a doctorate from an approved or accredited college to use the title Doctor of Oriental Medicine (D.O.M.) or Oriental Medical Doctor (O.M.D.).
In most states, medical doctors can practice acupuncture with no training; in many states, chiropractors may practice acupuncture with 100 or fewer hours of training.
Approximately one-third of the states that license acupuncturists require their clients to have a referral from a Western medical practitioner (an M.D., osteopath, chiropractor, or dentist) prior to or in conjunction with acupuncture treatment. In the remaining states, acupuncturists may accept patients without prior referral.
Training programs have become fairly standardized in recent years, so an acupuncturist with qualifications in one state has essentially the same training as in other states. If you are in a state that does not license acupuncturists, ask to see evidence that the acupuncturist has completed at least 3 years of training at an accredited institution. Check with your state medical board for the exact licensure title and requirements in your state.
States That License Acupuncturists
The following states license acupuncturists:
|District of Columbia||Maryland||North Carolina||Virginia|
The American Academy of Medical Acupuncture offers an acupuncturist referral list on their website.
Serious adverse effects associated with the use of acupuncture are rare.106-108 The most commonly reported problems include short-term pain from needle insertion, tiredness, and minor bleeding. There is one report of infection caused by acupuncture given to a person with diabetes.184
Some acupuncture points lie over the lungs and insertion to excessive depth could conceivably cause a pneumothorax (punctured lung). Because acupuncturists are trained to avoid this complication, it is a rare occurrence.
A recent report from China contained an example of another complication caused by excessively deep needling.109 A 44-year-old man was needled on the back of the neck at a commonly used acupuncture point just below the bony protuberance at the base of the skull. However, the acupuncturist inserted the needle too deeply and punctured a blood vessel in the skull. The client developed a severe headache with nausea and vomiting; a CAT scan showed bleeding in the brain, and a spinal tap found a small amount of blood in the cerebrospinal fluid. The severe headache, along with neck stiffness, continued for 28 days. The man was treated with standard pain medication, and the condition resolved itself without any permanent effects.
Infection due to the use of unclean needles has been reported in the past, but the modern practice of using disposable sterile needles appears to have eliminated this risk.
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296. da Cunha LA, Firoozmand LM, da Silva AP, et al. Efficacy of low-level laser therapy in the treatment of temporomandibular disorder. Int Dent J. 2008;58:213-217.
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308. Smith CA, Crowther CA, Collins CT, et al. Acupuncture to induce labor: a randomized controlled trial. Obstet Gynecol. 2008;112:1067-1074.
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311. Carrasco TG, Mazzetto MO, Mazzetto RG, et al. Low intensity laser therapy in temporomandibular disorder: a phase II double-blind study. Cranio. 2008;26:274-281.
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313. Lembo AJ, Conboy L, Kelley JM, et al. A treatment trial of acupuncture in IBS patients. Am J Gastroenterol. 2009;104:1489-1497.
314. So EW, Ng EH, Wong YY, Lau EY, Yeung WS, Ho PC. A randomized double blind comparison of real and placebo acupuncture in IVF treatment. Hum Reprod. 2009;24:341-8.
315. Lee MS, Shin BC, Ernst E. Acupuncture for treating menopausal hot flushes: a systematic review. Climacteric. 2009;12:16-25.
316. Yan T, Hui-Chan CW. Transcutaneous electrical stimulation on acupuncture points improves muscle function in subjects after acute stroke: a randomized controlled trial. J Rehabil Med. 2009;41:312-6.
317. Lee SH, Lee BC. Electroacupuncture relieves pain in men with chronic prostatitis/chronic pelvic pain syndrome: three-arm randomized trial. Urology. 2009;73:1036-41.
318. Wang MC, Hsu MC, Chien LW, Kao CH, Liu CF. Effects of auricular acupressure on menstrual symptoms and nitric oxide for women with primary dysmenorrhea. J Altern Complement Med. 2009;15:235-42.
319. Frey UH, Scharmann P, Löhlein C, Peters J. P6 acustimulation effectively decreases postoperative nausea and vomiting in high-risk patients. Br J Anaesth. 2009;102:620-5.
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321. Roscoe JA, Bushunow P, Jean-Pierre P, et al. Acupressure bands are effective in reducing radiation therapy-related nausea. J Pain Symptom Manage. 2009 Sep;38:381.
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324. Langhorst J, Klose P, Musial F, et al. Efficacy of acupuncture in fibromyalgia syndrome--a systematic review with a meta-analysis of controlled clinical trials. Rheumatology (Oxford). 2010;49:778.
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326. La Touche R, Angulo-Díaz-Parreño S, et al. Effectiveness of acupuncture in the treatment of temporomandibular disorders of muscular origin: a systematic review of the last decade. J Altern Complement Med. 2010;16:107.
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329. Cho SH, Hwang EW. Acupuncture for primary dysmenorrhoea: a systematic review. BJOG. 2010 Apr;117:509.
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332. Pfister DG, Cassileth BR, Deng GE, et al. Acupuncture for pain and dysfunction after neck dissection: results of a randomized controlled trial. J Clin Oncol. 2010 May 20;28(15):2565.
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335. Lee MS, Shin BC, Kim JI. Moxibustion for stroke rehabilitation: systematic review. Stroke. 2010 Apr;41(4):817.
336. Zhang ZJ, Chen HY, Yip KC, Ng R, Wong VT. The effectiveness and safety of acupuncture therapy in depressive disorders: systematic review and meta-analysis. J Affect Disord. 2010;124(1-2):9-21.
337. Sun JL, Sung MS, Huang MY, Cheng GC, Lin CC. Effectiveness of acupressure for residents of long-term care facilities with insomnia: a randomized controlled trial. Int J Nurs Stud. 2010;47(7):798-805.
338. Chen N, Zhou M, He L, Li N. Acupuncture for Bell's palsy. Cochrane Database Syst Rev. 2010;(8):CD002914.
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340. Paley C, Johnson M, Tashani O, Bagnall A. Acupuncture for cancer pain in adults. Cochrane Database Syst Rev. 2011;(1):CD007753.
342. Yang CP, Wang NH, Li TC, et al. A randomized clinical trial of acupuncture versus oral steroids for carpal tunnel syndrome: a long-term follow-up. J Pain. 2011;12(2):272-279.
343. Whites A, Rampes H, Liu J, Stead L, Campell J. Acupuncture and related interventions for smoking cessation. Cochrane Database Syst Rev. 2011;(1):CD000009.
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345. Kim YH, Kim KS, Lee HJ, Shim JC, Yoon SW. The efficacy of several neuromuscular monitoring modes at the p6 acupuncture point in preventing postoperative nausea and vomiting. Anesth Analg. 2011;112(4):819-823.
346. Hjelmstedt A, Shenoy ST, Stener-Victorin E, et al. Acupressure to reduce labor pain: a randomized controlled trial. Acta Obstet Gynecol Scand. 2010;89(11):1453-1459.
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375. Mackenzie IZ, Xu J, Cusick C, et al. Acupuncture for pain relief during induced labour in nulliparae: a randomised controlled study. BJOG. 2011;118(4):440-447.
376. Asher GN, Jonas DE, Coeytaux RR, et al. Auriculotherapy for pain management: a systematic review and meta-analysis of randomized controlled trials. J Altern Complement Med. 2010;16(10):1097-1108.
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378. Wang K, Bugge J, Bugge S. A randomised, placebo-controlled trial of manual and electrical acupuncture for the treatment of tinnitus. Complement Ther Med. 2010;18(6):249-255.
379. O'Sullivan EM, Higginson IJ. Clinical effectiveness and safety of acupuncture in the treatment of irradiation-induced xerostomia in patients with head and neck cancer: a systematic review. Acupunct Med. 2010;28(4):191-199.
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384. Coura LE, Manoel CH, Poffo R, Bedin A, Westphal GA. Randomised, controlled study of preoperative electroacupuncture for postoperative pain control after cardiac surgery. Acupunct Med. 2011;29(1):16-20.
385. Cheuk DK, Wong V, Chen WX. Acupuncture for autism spectrum disorders (ASD). Cochrane Database Syst Rev. 2011;9:CD007849.
386. de Luca AC, da Fonseca AM, Lopes CM, Bagnoli VR, Soares JM, Baracat EC. Acupuncture-ameliorated menopausal symptoms: single-blind, placebo-controlled, randomized trial. Climacteric. 2011;14(1):140-145.
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388. Neri I, Allais G, Vaccaro V, et al. Acupuncture treatment as breastfeeding support: preliminary data. J Altern Complement Med. 2011;17(2):133-137.
389. Marra C, Pozzi I, Ceppi L, Sicuri M, Veneziano F, Regalia AL. Wrist-ankle acupuncture as perineal pain relief after mediolateral episiotomy: a pilot study. J Altern Complement Med. 2011;17(3):239-241.
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393. Lomuscio A, Belletti S, Battezzati PM, Lombardi F. Efficacy of acupuncture in preventing atrial fibrillation recurrences after electrical cardioversion. J Cardiovasc Electrophysiol. 2011;22(3):241-247.
394. Johansson K, Bergström A, Schröder K, Foldevi M. Subacromial corticosteroid injection or acupuncture with home exercises when treating patients with subacromial impingement in primary care—a randomized clinical trial. Fam Pract. 2011;28(4):355-365.
395. Chang BH, Sommers E. Acupuncture and the relaxation response for treating gastrointestinal symptoms in HIV patients on highly active antiretroviral therapy. Acupunct Med. 2011;29(3):180-187.
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412. He L, Zhang XM. Clinical effect of sphenopalatine ganglion needling in treating primary trigeminal neuralgia of Liver-yang upsurge syndrome type. Chin J Integr Med. 2012;18(3):214-218.
413. Park J, White AR, Ernst E. Efficacy of acupuncture as a treatment for tinnitus: a systematic review. Arch Otolaryngol Head Surg. 2000;126(4):489-492.
414. Wu LL, Su CH, Liu CF. Effects of noninvasive electroacupuncture at Hegu (LI4) and Sanyinjiao (SP6) acupoints on dysmenorrhea: a randomized controlled trial. J Altern Complement Med. 2012;18(2):137-142.
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417. Kim YD, Heo I, et al. Acupuncture for posttraumatic stress disorder: a systematic review of randomized controlled trials and prospective clinical trials. Evid Based Complement Alternat Med. 2013; Epub ahead of print.
418. Li Y. Zheng H, et al. Addition of any form of acupuncture (including sham and placebo modalities) to usual care may improve acute low back pain. CMAJ. 2012;184(4):401-410.
419. Moretto EN, Wee B, et al. Interventions for treating persistent and intractable hiccups in adults. Cochrane Database Syst Rev. 2013:CD008768.
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422. Mikashima Y, Takagi T, et al. Efficacy of acupuncture during post-acute phase of rehabilitation after total knee arthroplasty. J Tradit Chin Med. 2012;32(4):545-548.
423. Ng SS, Leung WW, et al. Electroacupuncture reduces duration of postoperative ileus after laparoscopic surgery for colorectal cancer. Gastroenterology. 2013;144(2):307-313.
424. Chen R, Xiong J, et al. Heat-sensitive moxibustion for lumbar disc herniation: a meta-analysis of randomized controlled trials. J Tradit Chin Med. 2012;32(3):322-328.
425. Kannan P, Claydon LS. Some physiotherapy treatments may relieve menstrual pain in women with primary dysmenorrhea: a systematic review. J Physiother. 2014;60(1):13-21.
426. Karlson G, Bennicke P. Acupuncture in children: A prospective, randomized, controlled clinical trial of efficacy. Altern Ther Health Med. 2013;19(4):13-19.
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428. Kim TH, Lee MS, et al. Acupuncture for treating acute ankle sprains. Cochrane Database Syst Rev. 2014;6:CD009065.
429. Coulon C, Poleszczuk M, et al. Version of breech fetuses by moxibustion with acupuncture: a randomized controlled trial. Obstet Gynecol. 2014;124(1):32-39.
430. Hinman RS, McCrory P, et al. Acupuncture for chronic knee pain: A randomized clinical trial. JAMA. 2014;312(13):1313-1322.
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437. Glazov G, Yelland M, et al. Low-dose laser acupuncture for non-specific chronic low back pain: A double-blind randomised controlled trial. Acupunct Med. 2014;32(2):116-123.
438. Abbott R, Ayres I, et al. Effect of perineal self-acupuncture on constipation. A randomized controlled trial. J Gen Intern Med. 2014 Nov 18 [Epub ahead of print].
439. Chan YY, Lo WY. Clinical efficacy of acupuncture as an adjunct to methadone treatment services for heroin addicts: a randomized controlled trial. Am J Chin Med. 2014;42(3):569-586.
440. Manyanga T, Froese M, et al. Pain management with acupuncture in osteoarthritis: A systematic review and meta-analysis. BMC Complement Altern Med. 2014;14:312.
441. Xiong J, Liu Z. Effectiveness and safety of heat-sensitive moxibustion on bronchial asthma: A meta-analysis of randomized control trials. J Tradit Chin Med. 2014;34(4):392-400.
442. Mao JJ, Xie SX, et al. A randomised trial of electro-acupuncture for arthralgia related to aromatase inhibitor use. Eur J Cancer. 2014;50(2):267-276.
443. Xue CC, Zhang AL, Zhang CS, et al. Acupuncture for seasonal allergic rhinitis: a randomized controlled trial. Ann Allergy Asthma Immunol. 2015;115(4):317-324.
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445. Kucuk EV, Suceken FY, Binday A, et al. Effectiveness of acupuncture on chronic prostatitis-chronic pelvic pain syndrome category IIIB patients: a prospective, randomized, nonblinded, clinical trial. Urology. 2015;85(3):636-640.
446. Mulla SM, Wang L, Khokhar R, et al. Management of central poststroke pain: systematic review of randomized controlled trials. Stroke. 2015;46(10):2853-2860.
447. Liu F, Li ZM, Jiang YJ, Chen LD. A meta-analysis of acupuncture use in the treatment of cognitive impairment after stroke. J Altern Complement Med. 2014;20(7):535-544.
448. Shuai Z, Lian F, Li P, Yang W. Effect of transcutaneous electrical acupuncture point stimulation on endometrial receptivity in women undergoing frozen-thawed embryo transfer: a single-blind prospective randomised controlled trial. Acupunct Med. 2015;33(1):9-15.
449. Ee C, Chondrose P, Myers SP, et al. Acupuncture for menopausal hot flashes: a randomized trial. Ann Intern Med. 2016;164(3):146-154.
450. Chui HY, Hsieh YJ, Tsai PS. Acupuncture to reduce sleep disturbances in perimenopausal and postmenopausal women: a systematic review and meta-analysis. Obstet Gynecol. 2016;127(3):507-515.
451. Chung KF, Yeung WF, Yu YM, et al. Acupuncture for residual insomnia associated with major depressive disorder: a placebo- and sham-controlled, subject- and assessor-blind, randomized trial. J Clin Psychiatry. 2015;76(6):e752-e760.
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454. Cho HK, Park IJ, Jeong YM, Lee YJ, Hwang SH. Can perioperative acupuncture reduce the pain and vomiting experienced after tonsillectomy? A meta-analysis. Laryngoscope. 2016;126(3):608-615.
455. Liu Y, Xu M, Che X, et al. Effect of direct current pulse stimulating acupoints of JiaJi (T10-13) and Ciliao (BL 32) with Han's Acupoint Nerve Stimulator on labour pain in women: a randomized controlled clinical study. J Tradit Chin Med. 2015;35(6):620-625.
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457. Linde K, Allais G, Brinkhaus B, et al. Acupuncture for the prevention of episodic migraine. Cochrane Database Syst Rev. 2016;(6):CD001218.
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Last reviewed December 2015 by EBSCO CAM Review Board Last Updated: 10/17/2017