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Supplement Forms/Alternate Names:



Mannose is a natural sugar found in apples, green beans, and tomatoes. It has been used to prevent urinary tract infections. Mannose can be taken as a pill or powder.


500 milligrams 3 to 4 times daily

What Research Shows

May Be Effective

  • Urinary tract infection —may lower number of infections A1, A2

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take mannose in small doses for a short time. Not enough studies have been done to say whether it is safe to take for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding.


Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.



A1. Altarac S, Papeš D. Use of D-mannose in prophylaxis of recurrent urinary tract infections (UTIs) in women. BJU Int. 2014;113(1):9-10.

A2. Kranjčec B, Papeš D, et al. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. 2014;32(1):79-84.

Last reviewed March 2020 by EBSCO NAT Review Board Eric Hurwitz, DC  Last Updated: 6/29/2020