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Histidine a protein in the body. It has been used to ease swelling in the joints and to lower body mass index (BMI). Histidine can be taken as a pill or powder.


4 to 5 grams daily

What Research Shows

May Be Effective

  • Obesity —may lower BMI and improve insulin resistance 1

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take histidine in small doses for a short time. Not enough studies have been done to say whether it is safe to take for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding.


Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.



1. Feng RN, Niu YC, et al. Histidine supplementation improves insulin resistance through suppressed inflammation in obese women with the metabolic syndrome: a randomised controlled trial. Diabetologia. 2013;56(5):985-994.

Last reviewed February 2020 by EBSCO NAT Review Board Eric Hurwitz, DC  Last Updated: 5/27/2020