Polatuzumab vedotin-piiq injection is used along with bendamustine (Belrapzo, Treanda) and rituximab (Rituxan) in adults to treat a certain type of non-Hodgkin's lymphoma (NHL; a type of cancer that begins in a type of white blood cells that normally fights infection) that did not improve or improved but returned after treatment with at least two other chemotherapy medications. Polatuzumab vedotin-piiq is in a class of medications called antibody-drug conjugates. It works by killing cancer cells.
Polatuzumab vedotin-piiq comes as a powder to be mixed with liquid and injected intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually given over 30 to 90 minutes on day 1 of a 21 day cycle. The cycle may be repeated 6 times or long as recommended by your doctor. The length of your treatment depends on how well your body responds to the medication and the side effects that you experience.
You may experience a serious or life-threatening reaction while you receive a dose of polatuzumab vedotin-piiq injection or within 24 hours of receiving a dose. Your doctor may tell you to take certain medications before receiving your dose to prevent these reactions. A doctor or nurse will watch you closely to see how your body reacts to polatuzumab vedotin-piiq. Be sure to tell your doctor how you are feeling during your treatment with polatuzumab vedotin-piiq injection. Your doctor may prescribe other medications to help prevent or relieve these symptoms. If you experience any of the following symptoms during or after your infusion, tell your doctor immediately: chills, itching, hives, fever, flushing, rash, difficulty breathing, shortness of breath, or wheezing.
Your doctor may need to delay your treatment, adjust your dose, or stop your treatment if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with polatuzumab vedotin-piiq.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before receiving polatuzumab vedotin-piiq injection,
Unless your doctor tells you otherwise, continue your normal diet.
If you miss an appointment to receive a dose of polatuzumab vedotin-piiq, call your doctor right away.
Polatuzumab vedotin-piiq may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms or those listed in the HOW section, call your doctor immediately or get emergency medical treatment:
Polatuzumab vedotin-piiq injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( Web Site ) or by phone (1-800-332-1088).
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to polatuzumab vedotin-piiq injection.
Ask your pharmacist any questions you have about polatuzumab vedotin-piiq injection.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: July 15, 2019.