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Diindolylmethane is a compound found in cruciferous vegetables. These vegetables include broccoli, cabbage, kale, and brussels sprouts. The compound has been used to lower markers of cancer. It can be taken as a pill or by eating cruciferous vegetables.


150 milligrams twice daily

What Research Shows

Not Enough Data to Assess

  • Cervical dysplasia 1, 2

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take diindolylmethane for a short time. Not enough studies have been done to say whether it is safe to take for a long period.


Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.



1. Del Priore G, Gudipudi DK, et al. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol Oncol. 2010 Mar;116(3):464-467.

2. Castañon A, Tristram A, et al. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 2012 Jan 3;106(1):45-52.

Last reviewed February 2020 by EBSCO NAT Review Board Eric Hurwitz, DC  Last Updated: 5/27/2020