(eye fos' fa mide)
Ifosfamide can cause a severe decrease in the number of blood cells in your bone marrow. This may cause certain symptoms and may increase the risk that you will develop a serious or life-threatening infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, chills, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; bloody or black, tarry stools; bloody vomit; or vomiting blood or brown material that resembles coffee grounds.
Ifosfamide may cause severe or life-threatening damage to the nervous system. If you experience any of the following symptoms, call your doctor immediately: confusion; drowsiness; blurred vision; seeing things or hearing voices that do not exist (hallucinating); or pain, burning, numbness, tingling in the hands or feet; seizures; or coma (loss of consciousness for a period of time).
Ifosfamide may cause severe or life-threatening kidney problems. Kidney problems may occur during therapy or months or years after you stop receiving treatment. Tell your doctor if you have or have ever had kidney disease. If you experience any of the following symptoms, call your doctor immediately: decreased urination; swelling of the face, arms, hands, feet, ankles, or lower legs; or unusual tiredness or weakness.
Ifosfamide may cause severe urinary side effects. Tell your doctor if you have problems urinating. Your doctor may tell you not to receive ifosfamide or wait to start treatment until you are able to urinate regularly. Also tell your doctor if you have a urinary tract infection or if you have or have ever had radiation (x-ray) therapy to the bladder. Tell your doctor and pharmacist if you are taking or have ever received busulfan (Busulfex). If you experience any of the following symptoms, call your doctor immediately: blood in the urine or frequent, urgent, or painful urination. Your doctor will give you another medication to help prevent severe urinary side effects during your treatment with ifosfamide. You should also drink plenty of fluids and urinate frequently during your treatment to help reduce urinary side effects.
Keep all appointments with your doctor and the laboratory. Your doctor will order laboratory tests regularly before and during your treatment to check your body's response to ifsofamide and to treat side effects before they become severe.
WHY is this medicine prescribed?
Ifosfamide is used in combination with other medications to treat cancer of the testicles that has not improved or that has worsened after treatment with other medications or radiation therapy. Ifosfamide is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body.
HOW should this medicine be used?
Ifosfamide comes as powder to be mixed with liquid to be injected over at least 30 minutes intravenously (into a vein) by a doctor or nurse in a medical facility. It may be injected once a day for 5 days in a row. This treatment may be repeated every 3 weeks. The length of treatment depends on how well your body responds to treatment with ifosfamide.
Your doctor may need to delay your treatment if you experience certain side effects. It is important for you to tell your doctor how you are feeling during your treatment with ifosfamide.
Are there OTHER USES for this medicine?
Ifosfamide is also sometimes used to treat bladder cancer, lung cancer, cancer of the ovaries (cancer that begins in the female reproductive organs where eggs are formed), cancer of the cervix, and certain types of soft tissue or bone sarcomas (cancer that forms in muscles and bones). Talk to your doctor about the risks of using this medication for your condition.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before receiving ifosfamide,
What SPECIAL DIETARY instructions should I follow?
Do not eat large amounts of grapefruit or drink grapefruit juice while receiving this medication.
What SIDE EFFECTS can this medicine cause?
ifosfamide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
Ifosfamide may increase the risk that you will develop other cancers. Talk to your doctor about the risks of receiving ifosfamide injection.
Ifosfamide may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( http://www.fda.gov/Safety/MedWatch ) or by phone (1-800-332-1088).
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online athttps://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
What OTHER INFORMATION should I know?
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: March 15, 2013.
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