Levodopa and Carbidopa
(lee voe doe' pa) (kar bi doe' pa)
WHY is this medicine prescribed?
The combination of levodopa and carbidopa is used to treat the symptoms of Parkinson's disease and Parkinson's-like symptoms that may develop after encephalitis (swelling of the brain) or injury to the nervous system caused by carbon monoxide poisoning or manganese poisoning. Parkinson's symptoms, including tremors (shaking), stiffness, and slowness of movement, are caused by a lack of dopamine, a natural substance usually found in the brain. Levodopa is in a class of medications called central nervous system agents. It works by being converted to dopamine in the brain. Carbidopa is in a class of medications called decarboxylase inhibitors. It works by preventing levodopa from being broken down before it reaches the brain. This allows for a lower dose of levodopa, which causes less nausea and vomiting.
HOW should this medicine be used?
The combination of levodopa and carbidopa comes as a regular tablet, an orally disintegrating tablet, an extended-release (long-acting) tablet, and an extended-release (long-acting) capsule to take by mouth. The combination of levodopa and carbidopa also comes as a suspension (liquid) to be given into your stomach through a PEG-J tube (a tube surgically inserted through the skin and stomach wall) or sometimes through a naso-jejunal tube (NJ; a tube inserted into your nose and down to your stomach) using a special infusion pump. The regular and orally disintegrating tablets are usually taken three or four times a day. The extended-release tablet is usually taken two to four times a day. The extended-release capsule is usually taken three to five times a day. The suspension is usually given as a morning dose (given by infusion over 10 to 30 minutes) and then as a continuous dose (given by infusion over 16 hours), with extra doses given no more than once every 2 hours as needed to control your symptoms. Take levodopa and carbidopa at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take levodopa and carbidopa exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the extended-release tablets whole; do not chew or crush them.
Swallow the extended-release capsules whole; do not chew, divide, or crush them. Take the first daily dose of the extended-release capsule 1 to 2 hours before eating. If you have trouble swallowing, you can carefully open the extended-release capsule, sprinkle the entire contents on 1 to 2 tablespoons (15 to 30 mL) of apple sauce, and consume the mixture immediately. Do not store the mixture for future use.
To take the orally disintegrating tablet, remove the tablet from the bottle using dry hands and immediately place it in your mouth. The tablet will quickly dissolve and can be swallowed with saliva. No water is needed to swallow disintegrating tablets.
If you are switching from levodopa (Dopar or Larodopa; no longer available in the US) to the combination of levodopa and carbidopa, follow your doctor's instructions. You will probably be told to wait at least 12 hours after your last dose of levodopa to take your first dose of levodopa and carbidopa.
Your doctor may start you on a low dose of levodopa and carbidopa and gradually increase your dose of the regular or orally disintegrating tablet every day or every other day as needed. Your doctor may gradually increase your dose of the extended-release tablet or capsule after 3 days as needed.
To take the suspension, your doctor or pharmacist will show you how to use the pump to give your medication. Read the written instructions that come with the pump and the medication. Look at the diagrams carefully and be sure that you recognize all the parts of the pump and description of the keys. Ask your doctor or pharmacist to explain any part you do not understand.
Levodopa and carbidopa suspension comes in a single-use cassette to connect to the pump that will control the amount of medication you will receive during your infusion. Before use, remove the cassette containing the medication from the refrigerator and allow it to sit at room temperature for 20 minutes. Do not reuse a cassette or use it for longer than 16 hours. Dispose of the cassette at the end of the infusion even if it still contains medication.
When you begin taking levodopa and carbidopa suspension, your doctor will adjust your morning and continuous infusion doses and possibly the doses of your other Parkinson's disease medications to best control your symptoms. It usually takes about 5 days to reach a stable dose of the suspension, but your doses may need to be changed again over time depending on your ongoing response to the medication. Your prescribed dose of the suspension will be programmed into your pump by your doctor. Do not change the dose or settings on your pump unless you are told to do so by your doctor. Be careful to make sure your PEG-J tube does not become kinked, knotted, or blocked as this will affect the amount of medication that you receive.
Levodopa and carbidopa controls Parkinson's disease but does not cure it. It may take several months before you feel the full benefit of levodopa and carbidopa. Continue to take levodopa and carbidopa even if you feel well. Do not stop taking levodopa and carbidopa without talking to your doctor. If you suddenly stop taking levodopa and carbidopa, you could develop a serious syndrome that causes fever, rigid muscles, unusual body movements, and confusion. Your doctor will probably decrease your dose gradually. If your doctor tells you to stop taking levodopa and carbidopa suspension, a healthcare professional will remove your PEG-J tube; do not remove the tube yourself.
Ask your pharmacist or doctor for a copy of the manufacturer's patient information sheet for levodopa and carbidopa and also the Medication Guide for levodopa and carbidopa suspension.
Are there OTHER USES for this medicine?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before taking levodopa and carbidopa,
What SPECIAL DIETARY instructions should I follow?
Talk to your doctor if you plan on changing your diet to foods that are high in protein, such as meat, poultry, and dairy products.
What should I do IF I FORGET to take a dose?
Take the missed dose of the regular tablet, orally disintegrating tablet, extended-release (long-acting) tablet, or extended-release (long-acting) capsule as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
If you are using levodopa and carbidopa enteral infusion and will be disconnecting the infusion pump for a short time (less than 2 hours), other than the normal nightly disconnection, ask your doctor if you should use an extra dose before you disconnect the pump. If the infusion pump will be disconnected for longer than 2 hours, call your doctor; you probably will be advised to take levodopa and carbidopa by mouth while you are not using the suspension.
What SIDE EFFECTS can this medicine cause?
Levodopa and carbidopa may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of the following symptoms or those listed in the SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Store cassettes containing levodopa and carbidopa enteral suspension in the refrigerator in their original carton, protected from light. Do not freeze the suspension.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.http://www.upandaway.org
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online athttps://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to levodopa and carbidopa.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking levodopa and carbidopa.
Levodopa and carbidopa can lose its effect completely over time or only at certain times during the day. Call your doctor if your Parkinson's disease symptoms (shaking, stiffness, and slowness of movement) worsen or vary in severity.
As your condition improves and it is easier for you to move, be careful not to overdo physical activities. Increase your activity gradually to avoid falls and injuries.
Levodopa and carbidopa can cause false results in urine tests for sugar (Clinistix, Clinitest, and Tes-Tape) and ketones (Acetest, Ketostix, and Labstix).
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
¶ This branded product is no longer on the market. Generic alternatives may be available.
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: June 15, 2018.
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