Calaspargase pegol-mknl Injection
(kal as' par jase peg' ol)
WHY is this medicine prescribed?
Calaspargase pegol-mknl is used with other chemotherapy drugs to treat acute lymphocytic leukemia (ALL; a type of cancer of the white blood cells) in infants, children, and young adults aged 1 month to 21 years old. Calaspargase pegol-mknl is an enzyme that interferes with natural substances necessary for cancer cell growth. It works by killing or stopping the growth of cancer cells.
HOW should this medicine be used?
Calaspargase pegol-mknl comes as a solution (liquid) to be injected intravenously (into a vein) over 1 hour by a doctor or nurse in a medical office or hospital. It is usually given once every 3 weeks for as long as your doctor recommends treatment.
Your doctor may need to slow down your infusion, delay it, or stop your treatment with calaspargase pegol-mknl injection, or treat you with other medications if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with calaspargase pegol-mknl.
Calaspargase pegol-mknl may cause serious or life-threatening allergic reactions that are most likely to happen during the infusion or within 1 hour after the infusion. A doctor or nurse will monitor you during the infusion and for one hour after your infusion is finished to see if you are having a serious reaction to the medication. Tell your doctor or nurse immediately if you experience any of the following symptoms: swelling of the face, throat, tongue, lips, or eyes; flushing; hives; itching; rash; or difficulty swallowing or breathing.
Are there OTHER USES for this medicine?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before receiving calaspargase pegol-mknl injection,
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What SIDE EFFECTS can this medicine cause?
Calaspargase pegol-mknl injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms call your doctor immediately:
Calaspargase pegol-mknl may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( http://www.fda.gov/Safety/MedWatch ) or by phone (1-800-332-1088).
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to calaspargase pegol-mknl injection.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: April 15, 2019.
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