A sentinel lymph node biopsy is the removal and testing of specific lymph node tissue called sentinel nodes. The sentinel nodes are the lymph nodes to which cancer would spread first.
Lymph Node Biopsy
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Reasons for Procedure
This biopsy is done to determine if cancer cells have spread from the tumor to nearby lymph nodes. Cancer often spreads from the tumor to the nearest lymph node or nodes. These lymph nodes are called the sentinel nodes. It is important to understand that the sentinel node will probably be the first one to get cancer if the cancer has spread. For example, the sentinel nodes in breast cancer are often found in the armpit.
This biopsy is often done during cancer-removal surgery or prior to surgery. Sentinel node biopsy is part of the staging process. Staging is an attempt to determine how much the cancer has spread away from the original tumor. The cancerous tissue may have been biopsied already.
Complications are rare. But no procedure is completely free of risk. If you are planning to have this biopsy, your doctor will review a list of possible complications. These may include:
- Bleeding or bruising
- Nerve damage and chronic pain
- Allergy to dye
If the lymph nodes are removed, there is an increased risk of the following:
- Delayed wound healing
- Additional pain
—a condition in which fluids collect under the skin causing swelling
Some factors that may increase the risk of complications include:
- Recent or long-term illness
- Poor nutrition
- Use of certain medications
- Bleeding disorders
What to Expect
Prior to Procedure
Your doctor will do a physical exam. Tests may include the following:
- Blood tests
- Urine tests
Imaging studies may be done to look for cancer spread or the location of the sentinel nodes and may include:
Talk to your doctor about your medications. You may be asked to stop taking some medications up to one week before the procedure.
Prior to the procedure, you should also:
- Eat a light meal the night before. Do not eat or drink anything after midnight.
- Arrange for a ride to and from the hospital.
Depending on the location of the lymph node, you may be given one of the following:
- General anesthesia
—You will be asleep during the procedure.
- Local anesthesia—The area will be numb.
- Regional anesthesia—An area of your body will be numb.
Description of the Procedure
A blue dye, and often a radioactive tracer, will be injected into an area near the tumor. It may be done several hours before surgery. The dye and tracer will travel from the tumor area to the sentinel nodes. This will also help identify which nodes are the sentinel lymph nodes. A small incision will be made. The sentinel node(s) will be removed. The removed node will be checked for cancer cells. If cancer is found, the rest of the lymph nodes in that area will be removed.
If cancer is not seen in the sentinel node, it is unlikely that the cancer has spread to the other remaining lymph nodes. The other lymph nodes are not removed.
How Long Will It Take?
The biopsy takes about 30-60 minutes. Surgery to remove the entire cancer takes longer.
Will It Hurt?
Anesthesia will prevent pain during surgery. Pain and discomfort after the procedure can be managed with medications.
The result of the sentinel lymph node biopsy determines if additional lymph nodes need to be removed. It can also help determine the severity of your cancer.
Call Your Doctor
Contact your doctor if your recovery is not progressing as expected or you develop complications, such as:
- Signs of infection, including fever and chills
- Redness, swelling, increasing pain, excessive bleeding, or discharge from the incision site
- Redness, warmth, swelling, stiffness, or hardness in the extremity
- Dark or swollen fingers and toes
- Persistent nausea and/or vomiting
- Pain that you cannot control with the medications you were given
- Cough, shortness of breath, or chest pain
- New or unexpected symptoms
If you think you have an emergency, call for emergency medical services right away.
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Leong SP. The role of sentinel lymph nodes in malignant melanoma. Surg Clin North Am. 2000;80(6):1741-1757.
Sentinel lymph node biopsy: questions and answers. National Cancer Institute website. Available at: http://www.cancer.gov/about-cancer/diagnosis-staging/staging/sentinel-node-biopsy-fact-sheet. Accessed November 28, 2017.
Veronesi U, Paganelli G, Viale G, et al. Sentinel-lymph-node biopsy as a staging procedure in breast cancer: update of a randomized controlled study. Lancet Oncol. 2006(12);7:983-990.
1/22/2010 DynaMed Plus Systematic Literature Surveillancehttp://www.dynamed.com: Torres Lacomba M, Yuste Sánchez MJ, Zapico Goñi A, et al. Effectiveness of early physiotherapy to prevent lymphoedema after surgery for breast cancer: randomised, single blinded, clinical trial. BMJ. 2010;340:b5396.
Last reviewed November 2018 by
EBSCO Medical Review Board
James Cornell, MD
Last Updated: 12/20/2014