A. Age-Related Macular Degeneration
A1. Lawrenson JG, Evans JR. Omega 3 fatty acids for preventing or slowing the progression of age-related macular degeneration. Cochrane Database Syst Rev. 2015 Apr 9;(4):CD010015.
B. Amyotrophic Lateral Sclerosis
B1. Fitzgerald KC, O'Reilly ÉJ, et al. Dietary ω-3 polyunsaturated fatty acid intake and risk for amyotrophic lateral sclerosis. JAMA Neurol. 2014 Sep;71(9):1102-1110.
C1. Woods RK, Thien FC, et al. Dietary marine fatty acids (fish oil) for asthma in adults and children. Cochrane Database Syst Rev. 2002;(3):CD001283.
D. Attention Deficit Hyperactivity Disorder
D1. Chang JP, Su KP, et al. Omega-3 Polyunsaturated Fatty Acids in Youths with Attention Deficit Hyperactivity Disorder: a Systematic Review and Meta-Analysis of Clinical Trials and Biological Studies. Neuropsychopharmacology. 2018 Feb;43(3):534-545.
E. Chronic Kidney Disease
E1. Hu J, Liu Z, et al. Omega-3 fatty acid supplementation as an adjunctive therapy in the treatment of chronic kidney disease: a meta-analysis. Clinics (Sao Paulo). 2017 Jan 1;72(1):58-64.
F. Cognitive Decline
F1. Butler M, Nelson VA, et al. Over-the-Counter Supplement Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review. Ann Intern Med. 2018 Jan 2;168(1):52-62.
G. Crohn Disease
G1. Turner D, Zlotkin SH, et al. Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn’s disease. Cochrane Database Syst Rev. 2007;(2):CD006320.
H. Cystic Fibrosis
H1. Oliver C, Watson H. Omega-3 fatty acids for cystic fibrosis. Cochrane Database Syst Rev. 2016 Jan 5;(1):CD002201.
I1. Burckhardt M, Herke M, et al. Omega-3 fatty acids for the treatment of dementia. Cochrane Database Syst Rev. 2016 Apr 11;4:CD009002.
I2. Canhada S, Castro K, et al. Omega-3 fatty acids' supplementation in Alzheimer's disease: A systematic review. Nutr Neurosci. 2018 Oct;21(8):529-538.
J1. Appleton KM, Sallis HM, et al. Omega-3 fatty acids for depression in adults. Cochrane Database Syst Rev. 2015 Nov 5;(11):CD004692.
J2. Appleton KM, Sallis HM, et al. ω-3 Fatty acids for major depressive disorder in adults: an abridged Cochrane review. BMJ Open. 2016 Mar 2;6(3):e010172.
J3. Mocking RJ, Harmsen I, et al. Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder. Transl Psychiatry. 2016 Mar 15;6:e756.
J4. Sarris J, Murphy J, et al. Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses. Am J Psychiatry. 2016 Jun 1;173(6):575-587.
J5. Schefft C, Kilarski LL, et al. Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis. Eur Neuropsychopharmacol. 2017 Nov;27(11):1090-1109.
J6. Bae JH, Kim G. Systematic review and meta-analysis of omega-3-fatty acids in elderly patients with depression. Nutr Res. 2018 Feb;50:1-9.
J7. Bai ZG, Bo A, et al. Omega-3 polyunsaturated fatty acids and reduction of depressive symptoms in older adults: A systematic review and meta-analysis. J Affect Disord. 2018 Dec 1;241:241-248.
K1. Chen C, Yu X, et al. Effects of Omega-3 Fatty Acid Supplementation on Glucose Control and Lipid Levels in Type 2 Diabetes: A Meta-Analysis. PLoS One. 2015 Oct 2;10(10):e0139565.
L. Drug-Resistant Epilepsy
L1. Sarmento Vasconcelos V, Macedo CR, et al. Polyunsaturated fatty acid supplementation for drug-resistant epilepsy. Cochrane Database Syst Rev. 2016 Aug 17;(8):CD011014.
M. Dry Eye
M1. Molina-Leyva I, Molina-Leyva A, et al. Efficacy of nutritional supplementation with omega-3 and omega-6 fatty acids in dry eye syndrome: a systematic review of randomized clinical trials. Acta Ophthalmol. 2017 Dec;95(8):e677-e685.
M2. Giannaccare G, Pellegrini M, et al. Efficacy of Omega-3 Fatty Acid Supplementation for Treatment of Dry Eye Disease: A Meta-Analysis of Randomized Clinical Trials. Cornea. 2019 May;38(5):565-573.
N1. Pattanittum P, Kunyanone N, et al. Dietary supplements for dysmenorrhoea. Cochrane Database Syst Rev. 2016 Mar 22;3:CD002124.
O. Early and Pre-term Delivery
O1. Kar S, Wong M, et al. Effects of omega-3 fatty acids in prevention of early preterm delivery: a systematic review and meta-analysis of randomized studies. Eur J Obstet Gynecol Reprod Biol. 2016 Mar;198:40-46.
P. Heart Attack
P1. Burr ML, Fehily AM, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial infraction: diet and reinfarction trial (DART). Lancet. 1989;2(8666):757-761.
Q. Heart Disease
Q1. Alexander DD, Miller PE, et al. A Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies of Eicosapentaenoic and Docosahexaenoic Long-Chain Omega-3 Fatty Acids and Coronary Heart Disease Risk. Mayo Clin Proc. 2017 Jan;92(1):15-29.
Q2. AbuMweis S, Jew S, et al. Eicosapentaenoic acid and docosahexaenoic acid containing supplements modulate risk factors for cardiovascular disease: a meta-analysis of randomised placebo-control human clinical trials. J Hum Nutr Diet. 2018 Feb;31(1):67-84.
Q3. Abdelhamid AS, Brown TJ, et al. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2018 Nov 30;11:CD003177.
R. Heart Failure
R1. Wang C, Xiong B, et al. The Role of Omega-3 Polyunsaturated Fatty Acids in Heart Failure: A Meta-Analysis of Randomised Controlled Trials. Nutrients. 2016 Dec 30;9(1). pii: E18.
S1. Eslick GD, Howe PR, et al. Benefits of fish oil supplementation on hyperlipidemia: a systematic review and meta-analysis. Int J Cardiol. 2009;136(1):4-16.
T. Infant Support
T1. Jasani B, Simmer K, et al. Long chain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database Syst Rev. 2017 Mar 10;3:CD000376.
T2. Shulkin M, Pimpin L, et al. n-3 Fatty Acid Supplementation in Mothers, Preterm Infants, and Term Infants and Childhood Psychomotor and Visual Development: A Systematic Review and Meta-Analysis. J Nutr. 2018 Mar 1;148(3):409-418.
U. Insulin Sensitivity
U1. Gao H, Geng T, et al. Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis. Lipids Health Dis. 2017 Jul 3;16(1):131.
V. Kidney Failure
V1. Lim AK, Manley KJ, et al. Fish oil for kidney transplant recipients. Cochrane Database Syst Rev. 2016;(8):CD005282.
W. Liver Failure
W1. Zhu W, Dong C, et al. Effects of fish oil on serum lipid profile in dialysis patients: a systematic review and meta-analysis of randomized controlled trials. Lipids Health Dis. 2014;13:127.
X1. Maghsoumi-Norouzabad L, Mansoori A, et al. Effects of omega-3 fatty acids on the frequency, severity, and duration of migraine attacks: A systematic review and meta-analysis of randomized controlled trials. Nutr Neurosci. 2018 Nov;21(9):614-623.
Y. Non-Alcoholic Fatty Liver Disease
Y1. He XX, Wu XL, et al. Effectiveness of Omega-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis of Randomized Controlled Trials. PLoS One. 2016 Oct 6;11(10):e0162368.
Y2. Yan JH, Guan BJ, et al. Omega-3 polyunsaturated fatty acid supplementation and non-alcoholic fatty liver disease: A meta-analysis of randomized controlled trials. Medicine (Baltimore). 2018 Sep;97(37):e12271.
Z1. Bender N, Portmann M, et al. Fish or n3-PUFA intake and body composition: a systematic review and meta-analysis. Obes Rev. 2014 Aug;15(8):657-665.
Z2. Du S, Jin J, et al. Does Fish Oil Have and Anti-Obesity Effect in Overweight/Obese Adults? A Meta-Analysis of Randomized Controlled Trials. PLoS One. 2015;10(11):e0142652.
Z3. Zhang YY, Liu W, et al. Efficacy of Omega-3 Polyunsaturated Fatty Acids Supplementation in Managing Overweight and Obesity: A Meta-Analysis of Randomized Clinical Trials. J Nutr Health Aging. 2017;21(2):187-192.
AA. Pregnancy Support
AA1. Gunaratne AW, Makrides M, et al. Maternal prenatal and/or postnatal n-3 long chain polyunsaturated fatty acids (LCPUFA) supplementation for preventing allergies in early childhood. Cochrane Database Syst Rev. 2015 Jul 22;(7):CD010085.
AA2. Chen B, Ji X, et al. Fish oil supplementation improves pregnancy outcomes and size of the newborn: a meta-analysis of 21 randomized controlled trials. J Matern Fetal Neonatal Med. 2016;29(12):2017-2027.
AA3. Saccone G, Saccone I, et al. Omega-3-long-chain polyunsaturated fatty acids and fish oil supplementation during pregnancy: which evidence? J Matern Fetal Neonatal Med. 2016;29(15):2389-2397.
AA4. Freedman R, Hunter SK, et al. Prenatal Primary Prevention of Mental Illness by Micronutrient Supplements in Pregnancy. Am J Psychiatry. 2018 Jul 1;175(7):607-619.
AA5. Middleton P, Gomersall JC, et al. Omega-3 fatty acid addition during pregnancy. Cochrane Database Syst Rev. 2018 Nov 15;11:CD003402.
BB1. Upala S, Yong WC, et al. Effect of omega-3 fatty acids on disease severity in patients with psoriasis: A systematic review. Int J Rheum Dis. 2017 Apr;20(4):442-450.
BB2. Clark CCT, Taghizadeh M, et al. Efficacy of ω-3 supplementation in patients with psoriasis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2019 Apr;38(4):977-988.
CC1. Firth J, Rosenbaum S, et al. Adjunctive nutrients in first-episode psychosis: A systematic review of efficacy, tolerability and neurobiological mechanisms. Early Interv Psychiatry. 2018 Oct;12(5):774-783.
DD. Rheumatoid Arthritis
DD1. Proudman SM, James MJ, et al. Fish oil in recent onset rheumatoid arthritis: a randomised, double-blind controlled trial with algorithm-based drug use. Ann Rheum Dis. 2015;74(1):89-95.
DD2. Senftleber NK, Nielsen SM, et al. Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials. Nutrients. 2017 Jan 6;9(1). pii: E42.
EE1. Chang CH, Tseng PT, et al. Safety and tolerability of prescription omega-3 fatty acids: A systematic review and meta-analysis of randomized controlled trials. Prostaglandins Leukot Essent Fatty Acids. 2018 Feb;129:1-12.