Paget disease (PD) is a bone disorder. Normal bone is always being broken down and built again. With PD, bones are broken down too fast. New bone is loose and bulky instead of strong and compact. This leaves bones weak. They may bend over time. Early treatment can improve outcomes.
PD affects the bones of the:
Normal Bone Structure
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The exact cause is not known. It may be due to a viral infection, such as the measles.
PD is more common in people who are over 55 years of age. It usually happens in people of European descent.
Other things that may raise the risk are:
- A faulty SQSTM1 gene
- Having a family member with PD, such as a parent, sibling, or child
- Tobacco use
Most people do not have symptoms. Those who do may have:
- Bone and joint pain
- Bones that do not look the way they should
- Problems hearing
The doctor will ask about your symptoms and health history. A physical exam will be done.
Blood tests will be done.
Images will be taken of your body. This can be done with:
There is no cure. The goal of treatment is to manage symptoms. Choices are:
Medicines, such as:
- Pain relievers, such as acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs)
- Bisphosphonates to prevent the loss of bone and keep the disease from getting worse
- Calcium and vitamin D supplements
- Assistive devices, such as canes and shoe lifts
People who are not helped by these methods may need surgery to realign bones.
There are no known ways to prevent this health problem.
Paget disease of bone. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/paget-disease-of-bone. Accessed March 12, 2021.
Paget's disease of bone overview. NIH Osteoporosis and Related Bone Diseases National Resource Center website. Available at: https://www.bones.nih.gov/health-info/bone/pagets/patient-info. Accessed March 12, 2021.
Singer FR, Bone HG 3rd, et al. Paget's Disease of Bone: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2014 Dec;99(12):4408-4422.
Last reviewed December 2020 by
EBSCO Medical Review Board
Daniel A. Ostrovsky, MD
Last Updated: 03/12/2021