Enterovirus D68 (EV-D68) is a virus that can cause mild to severe infections of the lungs and breathing passages.
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EV-D68 passes from person to person through infected fluids of the mouth and nose. When an infected person coughs or sneezes the virus becomes airborne. A nearby healthy person may then inhale the virus. The virus can also exist on a surface once it has been touched by an infected person. The virus can then be transferred when a healthy person touches that surface and then touches their mouth or nose. Not all people who come in contact with the virus will develop an infection.
Infants are at increased risk of infection because their immune system has not fully developed. Children and teenagers are at increased risk due to high rate of exposure, poor use of preventive hygiene methods, and a lack of previous exposure that would protect from the virus.
Factors that may increase a child’s chances of a respiratory infection:
Mild symptoms are similar to a common cold and include:
More severe symptoms may include:
You will be asked about your symptoms and medical history. A physical exam will be done.
Your bodily fluids may be tested if there is a severe or long lasting infection. Evidence of EV-D68 may be found with:
Talk with your doctor about the best treatment plan for you. Options include:
Mild infections do not need special treatment. The goal is to ease the symptoms while the body fights the virus. Antibiotics are not effective against viruses.
Home care steps can help to relieve symptoms:
Note: Aspirin is not recommended for children with a current or recent viral infection. Check with the doctor before giving your child aspirin.
Severe infections cause breathing problems and wheezing. They may require treatment in a hospital. The treatment is aimed at opening up breathing passages and sometimes supporting breathing with oxygen. Treatment may include:
There is no vaccine available for EV-D68. To help reduce the chances of a respiratory infection:
Centers for Disease Control and Prevention
American Academy of Allergy Asthma & Immunology
Public Health Agency of Canada
Enterovirus D68. Centers for Disease Control and Prevention website. Available at:
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Accessed January 29, 2021.
Enterovirus D68 infection. EBSCO DynaMed website. Available at: http://www.dynamed.com/topics/dmp~AN~T905971/Enterovirus-D68-infection . Accessed January 29, 2021.
Enteroviruses. Oklahoma State Department of Health website. Available at: https://www.ok.gov/health2/documents/Enteroviruses%20%202014.pdf. Accessed January 29, 2021.
Enteroviruses and enterovirus D68. Washington State Department of Health website. Available at: https://www.doh.wa.gov/YouandYourFamily/IllnessandDisease/EnterovirusD68. Accessed January 29, 2021.
Midgley CM, Jackson MA, Selvarangan R, et al. Severe respiratory illness associated with enterovirus D68—Missouri and Illinois, 2014. MMWR Morb Mortal Wkly Rep. 2014;63(36):798-799.
Last reviewed March 2020 by
EBSCO Medical Review Board
David L. Horn, MD, FACP
Last Updated: 1/29/2021