Glycine
Supplement Forms/Alternate Names:
• L-glycine
Introduction
Glycine is a protein that is needed for brain function. It has been used to enhance mental function, lower blood pressure, and control blood glucose. Glycine can be taken as a pill or powder. It can also be applied to the skin as a cream.
Dosages3 to 15 grams daily
What Research Shows
May Be Effective
- Metabolic syndrome—may lower blood pressure B1
Not Enough Data to Assess
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Safety Notes
It is likely safe to take glycine in small doses for a short time. Not enough studies have been done to say whether it is safe to take for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding.
Interactions
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.
References [ + ]
A. Diabetes
A1. Guasch-Ferré M, Hruby A, et al. Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis. Diabetes Care. 2016 May;39(5):833-846.
B. Metabolic Syndrome
B1. Díaz-Flores M, Cruz M, et al. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure. Can J Physiol Pharmacol. 2013;91(10):855-860.
C. Psychotic Disorders
C1. Hoenders HJR, Bartels-Velthuis AA, et al. Natural Medicines for Psychotic Disorders: A Systematic Review. J Nerv Ment Dis. 2018 Feb;206(2):81-101.
Last reviewed February 2020 by EBSCO NAT Review Board
Eric Hurwitz, DC
Last Updated: 5/27/2020