This vaccine helps prevent typhoid (or typhoid fever)—a bacterial disease. The disease can cause flu-like symptoms. It can also lead to serious illness and death.
Typhoid is more common in Asia, Africa, and Latin America, but it does occur in the US.
The typhoid vaccine helps the immune system to recognize and attack the bacteria. There are two types of vaccine: a shot and an oral vaccine.
The vaccine is for those who:
The shot is needed at least 14 to 21 days before traveling. A booster is given every two years for those at risk.
The oral vaccine is given in 4 doses with a day off between doses. For those at risk, a booster is given every five years.
Most people will not have any problems with this vaccine. The most common side effects are fever, headache, and redness or swelling at the injection site. There may also be mild fever, rash, nausea, or vomiting. Rarely, a high fever or allergic reaction may occur.
Ask doctor about the risks, especially if you are pregnant or breastfeeding.
To help lower the risk of typhoid:
Health officials will check the source of an outbreak. This may involve food service and day care. They will also teach people how to properly wash their hands and prepare food.
Centers for Disease Control and Prevention
Family Doctor—American Academy of Family Physicians
Fowler CC, Chang SJ, et al. Emerging insights into the biology of typhoid toxin. Curr Opin Microbiol. 2017 Feb;35:70-77.
Typhoid vaccine, live. EBSCO DynaMed website. Available at: https://www.dynamed.com/drug-monograph/typhoid-vaccine-live. Accessed January 28, 2021.
Typhoid VI polysaccharide vaccine. EBSCO DynaMed website. Available at: https://www.dynamed.com/drug-monograph/typhoid-vi-polysaccharide-vaccine . Accessed January 28, 2021.
Typhoid VIS. Centers for Disease Control and Prevention website. Available at:https://www.cdc.gov/vaccines/hcp/vis/vis-statements/typhoid.html. Accessed January 28, 2021.
Last reviewed September 2020 by David L. Horn, MD, FACP
Last Updated: 1/28/2021