Ocrelizumab injection is used to treat adults with various forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control) including:
Ocrelizumab injection comes as a solution (liquid) to be injected intravenously (into a vein) by a doctor or nurse. It is usually given once every 2 weeks for the first two doses (at week 0 and week 2), and then infusions are given once every 6 months.
Ocrelizumab injection may cause serious reactions during an infusion and up to a day after receiving the infusion. You may be given other medications to treat or help prevent reactions to ocrelizumab. A doctor or nurse will watch you closely while receiving the infusion and for at least 1 hour afterwards to provide treatment in case of certain side effects to the medication. Your doctor may temporarily or permanently stop your treatment or decrease the dose, if you experience certain side effects. Tell your doctor or nurse if you experience any of the following during or within 24 hours after your infusion: rash; itching; hives; redness at the injection site; difficulty breathing or swallowing; cough; wheezing; rash; feeling faint; throat irritation; mouth or throat pain; shortness of breath; swelling of the face, eyes, mouth, throat, tongue, or lips; flushing; fever; fatigue; tiredness; headache; dizziness; nausea; or a racing heartbeat. Call your doctor immediately or get immediate emergency medical attention if you experience any of these symptoms after you leave your doctor's office or medical facility.
Ocrelizumab may help to control multiple sclerosis symptoms but does not cure them. Your doctor will watch you carefully to see how well ocrelizumab works for you. It is important to tell your doctor how you are feeling during your treatment.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ocrelizumab injection and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm)or the manufacturer's website to obtain the Medication Guide.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before receiving ocrelizumab injection,
Unless your doctor tells you otherwise, continue your normal diet.
If you miss an appointment to receive a ocrelizumab, call your doctor as soon as possible to reschedule your appointment.
Ocrelizumab may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms or those listed in the HOW section, call your doctor immediately or get emergency medical treatment:
Ocrelizumab may increase your risk of certain cancers, including breast cancer. Talk to your doctor about the risks of receiving this medication.
Ocrelizumab may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( Web Site) or by phone (1-800-332-1088).
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at Web Site. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment to check your body's response to ocrelizumab injection.
Ask your pharmacist any questions you have about ocrelizumab injection.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.