Osimertinib is used as a first treatment for a certain type of nonsmall-cell lung cancer (NSCLC) that has spread to other parts of the body. It is also used in people who could not be treated successfully with other similar chemotherapy medications. Osimertinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells and may help shrink tumors.
Osimertinib comes as a tablet to take by mouth. It is usually taken with or without food once a day. The length of your treatment depends on how well this medication works for you, and the side effects that you experience. Take osimertinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take osimertinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you cannot swallow the tablets, place the tablet into 4 tablespoons (2 oz [60 mL]) of water and stir until the tablet is in small pieces. Drink the mixture right away. Pour in another half a cup (4 oz [120 mL]) to a cup of water (8 oz [240 mL]) to the container you used, rinse, and drink to make sure you get the full dose of osimertinib. Do not use carbonated water or any other liquid to dissolve the osimertinib tablet. Do not crush the tablet or heat the mixture. If you have a nasogastric (NG) tube, your doctor or pharmacist will explain how to give this mixture through an NG tube.
Your doctor may temporarily or permanently stop your treatment or decrease your dose of osimertinib depending on the side effects that you experience. Be sure to talk to your doctor about how you are feeling during your treatment. Do not stop taking osimertinib without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before taking osimertinib,
Unless your doctor tells you otherwise, continue your normal diet.
Skip the missed dose and continue your regular dosing schedule. Do not take a dose late or take a double dose to make up for a missed one.
Osimertinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
Osimertinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( Web Site) or by phone (1-800-332-1088).
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( Web Site) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. Web Site
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at Web Site. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain heart function tests before and during your treatment to be sure it is safe for you to take osimertinib, and to check your body's response to the medication.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.